2016
Weight Gain and Metabolic Consequences of Risperidone in Young Children With Autism Spectrum Disorder
Scahill L, Jeon S, Boorin SJ, McDougle CJ, Aman MG, Dziura J, McCracken JT, Caprio S, Arnold LE, Nicol G, Deng Y, Challa SA, Vitiello B. Weight Gain and Metabolic Consequences of Risperidone in Young Children With Autism Spectrum Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2016, 55: 415-423. PMID: 27126856, PMCID: PMC4851735, DOI: 10.1016/j.jaac.2016.02.016.Peer-Reviewed Original ResearchConceptsWaist circumferenceWeight gainWeek 24Metabolic syndromeWeek 16Homeostatic model assessment-insulin resistanceMetabolic consequencesModel assessment-insulin resistanceBody mass index z-scoreAssessment-insulin resistanceLiver function testsTrial of risperidoneIndex z-scoreAutism spectrum disorderRapid weight gainRisperidone exposureBlood lipidsRisperidone monotherapyRisperidone treatmentFunction testsNormal weightInsulin resistanceAlanine aminotransferaseSpectrum disorderBlood samples
2015
Blunted suppression of acyl‐ghrelin in response to fructose ingestion in obese adolescents: The role of insulin resistance
Van Name M, Giannini C, Santoro N, Jastreboff AM, Kubat J, Li F, Kursawe R, Savoye M, Duran E, Dziura J, Sinha R, Sherwin RS, Cline G, Caprio S. Blunted suppression of acyl‐ghrelin in response to fructose ingestion in obese adolescents: The role of insulin resistance. Obesity 2015, 23: 653-661. PMID: 25645909, PMCID: PMC4548801, DOI: 10.1002/oby.21019.Peer-Reviewed Original ResearchConceptsAcyl ghrelinObese insulinGlucose ingestionInsulin resistanceObese adolescentsCross-over designFructose ingestionGut hormonesChildhood obesityInsulin sensitivityFructose consumptionEffect of glucoseDiminished suppressionRandom orderIngestionObesityPYYAdolescentsInsulinSuppression differencesGlucoseMinutesResponseGhrelinOIR
2014
Reversal of Early Abnormalities in Glucose Metabolism in Obese Youth: Results of an Intensive Lifestyle Randomized Controlled Trial
Savoye M, Caprio S, Dziura J, Camp A, Germain G, Summers C, Li F, Shaw M, Nowicka P, Kursawe R, DePourcq F, Kim G, Tamborlane WV. Reversal of Early Abnormalities in Glucose Metabolism in Obese Youth: Results of an Intensive Lifestyle Randomized Controlled Trial. Diabetes Care 2014, 37: 317-324. PMID: 24062325, PMCID: PMC3898759, DOI: 10.2337/dc13-1571.Peer-Reviewed Original ResearchConceptsStandard of careClinical careBlood glucoseObese adolescentsObese youthOral glucose tolerance test glucoseIntensive lifestyle modificationDiabetes Prevention ProgramStandard clinical careInsulin sensitivity indexHealthy lifestyle programType 2 diabetesRisk of T2DChildhood obesity epidemicΒ-cell dysfunctionLifestyle modificationControlled TrialsOGTT glucosePrimary outcomeGlucose toleranceInsulin resistanceLifestyle programAnthropometric assessmentEarly abnormalitiesGlucose levels
2012
Insulin resistance is associated with elevated serum pigment epithelium–derived factor (PEDF) levels in morbidly obese patients
Gattu AK, Birkenfeld AL, Jornayvaz F, Dziura J, Li F, Crawford SE, Chu X, Still CD, Gerhard GS, Chung C, Samuel V. Insulin resistance is associated with elevated serum pigment epithelium–derived factor (PEDF) levels in morbidly obese patients. Acta Diabetologica 2012, 49: 161-169. PMID: 22547263, DOI: 10.1007/s00592-012-0397-y.Peer-Reviewed Original ResearchConceptsPigment epithelium-derived factorMorbidly obese patientsPEDF levelsInsulin resistanceDiabetes mellitusHigh glucose mediumObese patientsSerum pigment epithelium-derived factor (PEDF) levelsPigment epithelium-derived factor levelsSerum pigment epithelium-derived factorHomeostasis model assessment scoreCounter-regulatory factorsSerum PEDF concentrationGastric bypass surgeryHuman hepatocytesSignificant risk factorsModel assessment scoreSerum PEDF levelsEpithelium-derived factorPrimary human hepatocytesHOMA scorePEDF concentrationDiabetes medicationsGastric bypassIR patients
2011
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
Kumashiro N, Erion DM, Zhang D, Kahn M, Beddow SA, Chu X, Still CD, Gerhard GS, Han X, Dziura J, Petersen KF, Samuel VT, Shulman GI. Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 16381-16385. PMID: 21930939, PMCID: PMC3182681, DOI: 10.1073/pnas.1113359108.Peer-Reviewed Original ResearchMeSH KeywordsAdultDiglyceridesEnzyme ActivationFatty LiverFemaleHumansInsulin ResistanceMaleMiddle AgedProtein Kinase C-epsilonConceptsNonalcoholic fatty liver diseaseFatty liver diseaseHepatic DAG contentInsulin resistanceHepatic insulin resistanceLiver diseaseHepatic steatosisCellular mechanismsHomeostatic model assessmentInsulin resistance indexMarkers of inflammationType 2 diabetesER stress markersLipid dropletsHepatic diacylglycerol contentEndoplasmic reticulum stressActivation of PKCεLiver biopsyNondiabetic individualsHepatocellular lipidsInsulin sensitivityCytoplasmic lipid dropletsDAG contentResistance indexAnimal models
2010
Apolipoprotein C3 Gene Variants in Nonalcoholic Fatty Liver Disease
Petersen KF, Dufour S, Hariri A, Nelson-Williams C, Foo JN, Zhang XM, Dziura J, Lifton RP, Shulman GI. Apolipoprotein C3 Gene Variants in Nonalcoholic Fatty Liver Disease. New England Journal Of Medicine 2010, 362: 1082-1089. PMID: 20335584, PMCID: PMC2976042, DOI: 10.1056/nejmoa0907295.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseFatty liver diseasePlasma triglyceride clearanceLiver diseaseFat tolerance testPlasma triglyceride concentrationsInsulin resistanceApolipoprotein C3Wild-type homozygotesIndian menTriglyceride clearanceTriglyceride concentrationsC3 concentrationsTriglyceride contentApolipoprotein C3 gene variantsHealthy Asian Indian menOral fat tolerance testType 2 diabetes mellitusVariant allelesIntravenous fat tolerance testLiver triglyceride contentHepatic triglyceride contentSingle nucleotide polymorphismsVariant allele carriersHepatic insulin resistance
2009
Specific Relation Between Abdominal Obesity and Early-Phase Hyperglycemia Is Modulated by Hepatic Insulin Resistance in Healthy Older Women
DiPietro L, Dziura J, Yeckel CW. Specific Relation Between Abdominal Obesity and Early-Phase Hyperglycemia Is Modulated by Hepatic Insulin Resistance in Healthy Older Women. Diabetes Care 2009, 33: 165-167. PMID: 19808930, PMCID: PMC2797964, DOI: 10.2337/dc09-1365.Peer-Reviewed Original ResearchConceptsHepatic insulin resistanceOral glucose tolerance testAbdominal obesityGlucose tolerance testHealthy older womenInsulin resistanceOlder womenTolerance testLow-dose insulin infusionHepatic glucose productionGlucose excursionsInsulin infusionPlasma glucoseAbdominal circumferenceInsulin concentrationsInsulin suppressionMin postchallengeObesityGlycemic responseClamp techniqueGlucose productionWomenHyperglycemiaProduction suppressionPostchallengeSimple Exercise Recovery Index for Sympathetic Overactivity Is Linked to Insulin Resistance
YECKEL CW, GULANSKI B, ZGORSKI ML, DZIURA J, PARISH R, SHERWIN RS. Simple Exercise Recovery Index for Sympathetic Overactivity Is Linked to Insulin Resistance. Medicine & Science In Sports & Exercise 2009, 41: 505-515. PMID: 19204601, DOI: 10.1249/mss.0b013e31818afa2f.Peer-Reviewed Original ResearchConceptsOral glucose tolerance testSympathetic overactivityInsulin resistancePercent body fatExercise recoveryHR recoveryParasympathetic functionBody fatWhole-body insulin sensitivity indexEffective clinical meansHomeostasis assessment modelRecovery indexMeal-induced thermogenesisGlucose tolerance testInsulin sensitivity indexNovel functional indicesParasympathetic dysfunctionCause mortalitySympathetic dysfunctionSympathetic functionObese adolescentsTolerance testInitial plateau phaseIntense exerciseParasympathetic control
2008
Primary Defects in β-Cell Function Further Exacerbated by Worsening of Insulin Resistance Mark the Development of Impaired Glucose Tolerance in Obese Adolescents
Cali AM, Man CD, Cobelli C, Dziura J, Seyal A, Shaw M, Allen K, Chen S, Caprio S. Primary Defects in β-Cell Function Further Exacerbated by Worsening of Insulin Resistance Mark the Development of Impaired Glucose Tolerance in Obese Adolescents. Diabetes Care 2008, 32: 456-461. PMID: 19106382, PMCID: PMC2646028, DOI: 10.2337/dc08-1274.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildFemaleGlucose IntoleranceGlucose Tolerance TestHumansInsulin ResistanceInsulin-Secreting CellsMaleObesityConceptsImpaired glucose toleranceNormal glucose toleranceBeta-cell functionBeta-cell responsivityObese adolescentsGlucose toleranceDisposition indexOral glucose tolerance testProgressive declinePre-diabetic stateGlucose tolerance testBMI z-scorePrimary defectGlucose intoleranceGlucose areaTolerance testPlasma glucoseInsulin sensitivityC-peptideInsulin secretionNonprogressorsZ-scoreNatural historyProgressorsPercent fatShort‐term metabolic and cardiovascular effects of metformin in markedly obese adolescents with normal glucose tolerance
Burgert TS, Duran EJ, Goldberg‐Gell R, Dziura J, Yeckel CW, Katz S, Tamborlane WV, Caprio S. Short‐term metabolic and cardiovascular effects of metformin in markedly obese adolescents with normal glucose tolerance. Pediatric Diabetes 2008, 9: 567-576. PMID: 18761646, DOI: 10.1111/j.1399-5448.2008.00434.x.Peer-Reviewed Original ResearchConceptsNormal glucose toleranceInsulin sensitivityGlucose toleranceObese childrenDouble-blind clinical trialType 2 diabetes mellitusSubcutaneous fatCardio-metabolic consequencesBaseline insulin sensitivityImproved insulin sensitivityInsulin-resistant adolescentsHeart rate recoveryLong-term treatmentDeep subcutaneous fatShort-term useMagnetic resonance imagingPlacebo groupCardiovascular effectsDiabetes mellitusMetS groupClinical effectsLipid parametersInsulin sensitizersInflammatory cytokinesObese adolescentsAbdominal Obesity in Older Women: Potential Role for Disrupted Fatty Acid Reesterification in Insulin Resistance
Yeckel CW, Dziura J, DiPietro L. Abdominal Obesity in Older Women: Potential Role for Disrupted Fatty Acid Reesterification in Insulin Resistance. The Journal Of Clinical Endocrinology & Metabolism 2008, 93: 1285-1291. PMID: 18198225, PMCID: PMC2291490, DOI: 10.1210/jc.2007-1875.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal FatAdipose TissueAgedCross-Sectional StudiesFatty AcidsFemaleHumansInsulin ResistanceLipolysisObesityConceptsFatty acid reesterificationPeripheral insulin resistanceAbdominal obesityInsulin resistanceHepatic glucose productionAbdominal adiposityOlder womenGlucose utilizationGeneral Clinical Research CenterBasal hepatic glucose productionGlucose productionFree fatty acid metabolismExcess abdominal adiposityPerturbed glucose metabolismGlucose-lowering medicationsHormone replacement therapyClinical Research CenterPeripheral glucose utilizationGlycerol appearance rateInactive older womenTotal body fatCross-sectional studyAbdominal circumference valuesInsulin-stimulated suppressionFree fatty acid ratio
2007
Interethnic Differences in Muscle, Liver and Abdominal Fat Partitioning in Obese Adolescents
Liska D, Dufour S, Zern TL, Taksali S, Calí AM, Dziura J, Shulman GI, Pierpont BM, Caprio S. Interethnic Differences in Muscle, Liver and Abdominal Fat Partitioning in Obese Adolescents. PLOS ONE 2007, 2: e569. PMID: 17593968, PMCID: PMC1892806, DOI: 10.1371/journal.pone.0000569.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingLiver fat contentHepatic fat contentInsulin resistanceObese adolescentsAfrican AmericansOral glucose tolerance testingObese Hispanic adolescentsAbdominal fat distributionGlucose tolerance testingType 2 diabetesTotal body fatEthnic differencesClear ethnic differencesVisceral fatInsulin sensitivityFat distributionTolerance testingIMCL levelsMultiethnic cohortObese youthFat contentAbdominal cavityBody fatSoleus muscleEffects of a Weight Management Program on Body Composition and Metabolic Parameters in Overweight Children: A Randomized Controlled Trial
Savoye M, Shaw M, Dziura J, Tamborlane WV, Rose P, Guandalini C, Goldberg-Gell R, Burgert TS, Cali AM, Weiss R, Caprio S. Effects of a Weight Management Program on Body Composition and Metabolic Parameters in Overweight Children: A Randomized Controlled Trial. JAMA 2007, 297: 2697-2704. PMID: 17595270, DOI: 10.1001/jama.297.24.2697.Peer-Reviewed Original ResearchConceptsWeight management programWeight management groupOverweight childrenMetabolic complicationsInsulin resistanceBody fatBody compositionControl groupArray of comorbiditiesMost overweight childrenSix-month improvementsHomeostasis model assessmentPediatric obesity clinicSerious metabolic complicationWeight management counselingType 2 diabetesMajor health issueFamily-based programsMixed ethnic groupsMonths of studyHOMA-IRObesity clinicOverweight adultsControlled TrialsPediatric obesity
2006
Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men
Petersen KF, Dufour S, Feng J, Befroy D, Dziura J, Man C, Cobelli C, Shulman GI. Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 18273-18277. PMID: 17114290, PMCID: PMC1693873, DOI: 10.1073/pnas.0608537103.Peer-Reviewed Original ResearchConceptsAsian Indian menInsulin resistanceInsulin sensitivity indexLiver diseaseNonalcoholic fatty liver diseaseOral glucose tolerance testType 2 diabetes mellitusAsian IndiansWhole-body insulin sensitivityFatty liver diseaseIL-6 concentrationsTreatment of T2DMIntramyocellular lipid contentGlucose tolerance testPathogenesis of T2DMProton magnetic resonance spectroscopyImportant therapeutic implicationsEthnic groupsDiabetes mellitusImportant ethnic differencesCaucasian manTolerance testInsulin sensitivityIntramyocellular lipidsLean individualsAdiponectin in Childhood and Adolescent Obesity and Its Association with Inflammatory Markers and Components of the Metabolic Syndrome
Winer JC, Zern TL, Taksali SE, Dziura J, Cali AM, Wollschlager M, Seyal AA, Weiss R, Burgert TS, Caprio S. Adiponectin in Childhood and Adolescent Obesity and Its Association with Inflammatory Markers and Components of the Metabolic Syndrome. The Journal Of Clinical Endocrinology & Metabolism 2006, 91: 4415-4423. PMID: 16926246, DOI: 10.1210/jc.2006-0733.Peer-Reviewed Original ResearchConceptsC-reactive proteinAdiponectin levelsMetabolic syndromeObese childrenInsulin resistanceChildhood obesityLow high-density lipoprotein cholesterolStandard oral glucose tolerance testBody mass index z-scoreHigh-density lipoprotein cholesterolOral glucose tolerance testHigher CRP levelsChronic inflammatory stateMarkers of inflammationPlasma lipid profileGlucose tolerance testIndex z-scorePotential confounding variablesCRP levelsInflammatory markersLipoprotein ratioHigh triglyceridesLipoprotein cholesterolInflammatory stateProinflammatory cytokinesAlanine Aminotransferase Levels and Fatty Liver in Childhood Obesity: Associations with Insulin Resistance, Adiponectin, and Visceral Fat
Burgert TS, Taksali SE, Dziura J, Goodman TR, Yeckel CW, Papademetris X, Constable RT, Weiss R, Tamborlane WV, Savoye M, Seyal AA, Caprio S. Alanine Aminotransferase Levels and Fatty Liver in Childhood Obesity: Associations with Insulin Resistance, Adiponectin, and Visceral Fat. The Journal Of Clinical Endocrinology & Metabolism 2006, 91: 4287-4294. PMID: 16912127, DOI: 10.1210/jc.2006-1010.Peer-Reviewed Original ResearchConceptsIntrahepatic fat accumulationAlanine aminotransferase levelsHepatic fat fractionVisceral fatInsulin sensitivityMagnetic resonance imagingFat accumulationAminotransferase levelsMetabolic syndromeFatty liverInsulin resistanceChildhood obesityResonance imagingLipid metabolismNonalcoholic fatty liver diseaseHispanic race/ethnicityAbdominal fat partitioningSerum aminotransferase elevationFatty liver diseaseBiomarkers of inflammationHepatic fat accumulationReduced insulin sensitivityFat fractionRace/ethnicityAminotransferase elevationEthnic differences in beta cell adaptation to insulin resistance in obese children and adolescents
Weiss R, Dziura JD, Burgert TS, Taksali SE, Tamborlane WV, Caprio S. Ethnic differences in beta cell adaptation to insulin resistance in obese children and adolescents. Diabetologia 2006, 49: 571-579. PMID: 16456682, DOI: 10.1007/s00125-005-0109-z.Peer-Reviewed Original ResearchConceptsEarly insulin responseObese childrenInsulin resistanceInsulin clearanceInsulin responseAims/hypothesisThe prevalenceObesity-related insulin resistanceOral glucose loadLower insulin clearanceType 2 diabetesAcute insulin responseGlucose tolerance levelsAltered glucose metabolismSevere insulin resistanceBeta-cell adaptationAfrican American subjectsEthnic groupsHypothesisThe prevalenceGlucose toleranceGlucose loadInsulin sensitivityGlucose metabolismMethodsSeven hundredClearanceHispanic origin
2005
Microalbuminuria in pediatric obesity: prevalence and relation to other cardiovascular risk factors
Burgert TS, Dziura J, Yeckel C, Taksali SE, Weiss R, Tamborlane W, Caprio S. Microalbuminuria in pediatric obesity: prevalence and relation to other cardiovascular risk factors. International Journal Of Obesity 2005, 30: 273-280. PMID: 16231019, DOI: 10.1038/sj.ijo.0803136.Peer-Reviewed Original ResearchConceptsUrine albumin-creatinine ratioPresence of microalbuminuriaBody mass indexCV riskBlood pressureMetabolic syndromeRisk factorsIndividual CV risk factorsRelationship of microalbuminuriaAlbumin-creatinine ratioCardiovascular risk factorsCV risk factorsOral glucose toleranceInsulin sensitivity indexRisk factor constellationsEarly vasculopathyMicroalbuminuric rangeCardiovascular eventsCV diseaseGross proteinuriaInflammatory markersEndothelial dysfunctionNondiabetic adultsObesity clinicCreatinine ratioExercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training
DiPietro L, Dziura J, Yeckel CW, Neufer PD. Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training. Journal Of Applied Physiology 2005, 100: 142-149. PMID: 16141382, DOI: 10.1152/japplphysiol.00474.2005.Peer-Reviewed Original ResearchConceptsHigh-intensity exercise trainingIntensity exercise trainingExercise trainingAerobic trainingInsulin sensitivityExercise volumeOlder womenGlucose utilizationModerate-intensity aerobic trainingTwo-step euglycemic-hyperinsulinemic clampInsulin-stimulated glucose utilizationHigh-intensity aerobic trainingDual-energy X-ray absorptiometryHigher insulin doseLower insulin doseHealthy older womenEuglycemic hyperinsulinemic clampLow-intensity exerciseTotal body fatAdipose tissue lipolysisImproved glucose utilizationX-ray absorptiometrySuppression of lipolysisFinal exercise boutInsulin-stimulated suppressionThe “Obese Insulin-Sensitive” Adolescent: Importance of Adiponectin and Lipid Partitioning
Weiss R, Taksali SE, Dufour S, Yeckel CW, Papademetris X, Cline G, Tamborlane WV, Dziura J, Shulman GI, Caprio S. The “Obese Insulin-Sensitive” Adolescent: Importance of Adiponectin and Lipid Partitioning. The Journal Of Clinical Endocrinology & Metabolism 2005, 90: 3731-3737. PMID: 15797955, DOI: 10.1210/jc.2004-2305.Peer-Reviewed Original ResearchConceptsInsulin sensitivityVisceral fatLipid depositionObese insulin-resistant adolescentsObese insulin-sensitive subjectsNormal glucose tolerancePeripheral insulin sensitivityIntramyocellular lipid contentBody mass indexInsulin-sensitive subjectsHyperinsulinemic-euglycemic clampInsulin-resistant adolescentsInsulin-sensitive controlsWide interindividual variationLipid partitioningLower lipid depositionPercent body fatMagnetic resonance imagingImportance of adiponectinObese insulinObese groupGlucose toleranceMass indexObese adolescentsIntramyocellular lipids