2021
Use of peripheral arterial tonometry in detection of abnormal coronary flow reserve
Gaeta M, Nowroozpoor A, Dziura J, D'Onofrio G, Sinusas AJ, Safdar B. Use of peripheral arterial tonometry in detection of abnormal coronary flow reserve. Microvascular Research 2021, 138: 104223. PMID: 34256085, PMCID: PMC10227886, DOI: 10.1016/j.mvr.2021.104223.Peer-Reviewed Original ResearchConceptsLower coronary flow reserveCoronary flow reserveCoronary microvascular dysfunctionCoronary artery diseaseClinical screening toolPET/CTFlow reserveRubidium-82 positron emission tomography/Large vessel coronary artery diseaseNormal coronary flow reserveTraditional CAD risk factorsVessel coronary artery diseaseAbnormal coronary flow reservePositron emission tomography/Screening toolPeripheral arterial tonometryCAD risk factorsEmission tomography/Presence of calcificationLower RHIHyperemia indexArterial tonometryMicrovascular dysfunctionArtery diseaseAugmentation index
2020
Effect of a Multifactorial Fall Injury Prevention Intervention on Patient Well‐Being: The STRIDE Study
Gill TM, Bhasin S, Reuben DB, Latham NK, Araujo K, Ganz DA, Boult C, Wu AW, Magaziner J, Alexander N, Wallace RB, Miller ME, Travison TG, Greenspan SL, Gurwitz JH, Rich J, Volpi E, Waring SC, Manini TM, Min LC, Teresi J, Dykes PC, McMahon S, McGloin JM, Skokos EA, Charpentier P, Basaria S, Duncan PW, Storer TW, Gazarian P, Allore HG, Dziura J, Esserman D, Carnie MB, Hanson C, Ko F, Resnick NM, Wiggins J, Lu C, Meng C, Goehring L, Fagan M, Correa‐de‐Araujo R, Casteel C, Peduzzi P, Greene EJ. Effect of a Multifactorial Fall Injury Prevention Intervention on Patient Well‐Being: The STRIDE Study. Journal Of The American Geriatrics Society 2020, 69: 173-179. PMID: 33037632, PMCID: PMC8178516, DOI: 10.1111/jgs.16854.Peer-Reviewed Original ResearchConceptsSerious fall injuriesFall injuriesMultifactorial interventionPhysical functionOutcomes Measurement Information System (PROMIS) AnxietyLeast square mean changePragmatic cluster-randomized trialMean scoreCommunity-living personsIntervention group's mean scoreInjury prevention interventionsPrimary care practicesFalls Efficacy ScaleCluster-randomized trialUsual careElders StudyDisability InstrumentSTRIDE studyDepression ScaleMean changePrevention interventionsHigh riskCare practicesControl groupMeaningful improvementsA Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries
Bhasin S, Gill TM, Reuben DB, Latham NK, Ganz DA, Greene EJ, Dziura J, Basaria S, Gurwitz JH, Dykes PC, McMahon S, Storer TW, Gazarian P, Miller ME, Travison TG, Esserman D, Carnie MB, Goehring L, Fagan M, Greenspan SL, Alexander N, Wiggins J, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace RB, Casteel C, Resnick NM, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Meng C, Allore H, Brawley BF, Eder R, McGloin JM, Skokos EA, Duncan PW, Baker D, Boult C, Correa-de-Araujo R, Peduzzi P. A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries. New England Journal Of Medicine 2020, 383: 129-140. PMID: 32640131, PMCID: PMC7421468, DOI: 10.1056/nejmoa2002183.Peer-Reviewed Original ResearchConceptsSerious fall injuriesFall injuriesIntervention groupControl groupUsual careMultifactorial interventionRate of hospitalizationPrimary care practicesCluster-randomized trialCommunity-dwelling adultsFirst-event analysisYears of ageHealth care systemRate of fallElectronic health recordsBaseline characteristicsPrimary outcomeRandomized trialsMean ageEfficacy trialsIndividualized planCare practicesInjuryMultifactorial strategyEvent rates
2019
Integrated stepped alcohol treatment for patients with HIV and liver disease: A randomized trial
Edelman EJ, Maisto SA, Hansen NB, Cutter CJ, Dziura J, Deng Y, Fiellin LE, O'Connor PG, Bedimo R, Gibert CL, Marconi VC, Rimland D, Rodriguez-Barradas MC, Simberkoff MS, Tate JP, Justice AC, Bryant KJ, Fiellin DA. Integrated stepped alcohol treatment for patients with HIV and liver disease: A randomized trial. Journal Of Substance Use And Addiction Treatment 2019, 106: 97-106. PMID: 31540617, PMCID: PMC7244228, DOI: 10.1016/j.jsat.2019.08.007.Peer-Reviewed Original Research
2017
Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE): A Cluster-Randomized Pragmatic Trial of a Multifactorial Fall Injury Prevention Strategy: Design and Methods
Bhasin S, Gill TM, Reuben DB, Latham NK, Gurwitz JH, Dykes P, McMahon S, Storer TW, Duncan PW, Ganz DA, Basaria S, Miller ME, Travison TG, Greene EJ, Dziura J, Esserman D, Allore H, Carnie MB, Fagan M, Hanson C, Baker D, Greenspan SL, Alexander N, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace R, Casteel C, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Margolis S, Eder R, McGloin JM, Skokos E, Wiggins J, Garber L, Clauser SB, Correa-De-Araujo R, Peduzzi P. Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE): A Cluster-Randomized Pragmatic Trial of a Multifactorial Fall Injury Prevention Strategy: Design and Methods. The Journals Of Gerontology Series A 2017, 73: 1053-1061. PMID: 29045582, PMCID: PMC6037050, DOI: 10.1093/gerona/glx190.Peer-Reviewed Original ResearchMeSH KeywordsAccidental FallsAgedAged, 80 and overFemaleHumansMaleMotivational InterviewingRisk AssessmentWounds and InjuriesConceptsSerious fall injuriesInjury prevention strategiesFall injuriesPragmatic trialHealth care systemUsual carePrevention strategiesControl groupOlder adultsCare systemMultifactorial risk assessmentCommunity-living personsEnhanced usual carePrimary outcome rateIndividualized care plansPrimary care practicesTarget sample sizeEvidence-based informationSecondary outcomesPrimary outcomeOutcome ratesComanagement modelFall preventionSTRIDE studyMedical attentionEvaluation of a novel 5-group classification system of sepsis by vasopressor use and initial serum lactate in the emergency department
Swenson KE, Dziura JD, Aydin A, Reynolds J, Wira CR. Evaluation of a novel 5-group classification system of sepsis by vasopressor use and initial serum lactate in the emergency department. Internal And Emergency Medicine 2017, 13: 257-268. PMID: 28132131, DOI: 10.1007/s11739-017-1607-y.Peer-Reviewed Original ResearchConceptsInitial serum lactate levelSerum lactate levelsEmergency departmentLactate elevationVasoplegic shockLactate levelsCryptic shockVasopressor useInfected patientsShock mortalityHigh-risk ED patientsGroup mortality rateInitial serum lactateVasopressor-dependent patientsIdentifiable risk factorsSepsis-3 definitionRisk-stratify patientsHigh-risk subgroupsInitial lactate levelProximal phaseVasopressor dependenceVasopressor requirementHospital outcomesED patientsSerum lactate
2016
Laminectomy plus Fusion versus Laminectomy Alone for Lumbar Spondylolisthesis
Ghogawala Z, Dziura J, Butler WE, Dai F, Terrin N, Magge SN, Coumans JV, Harrington JF, Amin-Hanjani S, Schwartz JS, Sonntag VK, Barker FG, Benzel EC. Laminectomy plus Fusion versus Laminectomy Alone for Lumbar Spondylolisthesis. New England Journal Of Medicine 2016, 374: 1424-1434. PMID: 27074067, DOI: 10.1056/nejmoa1508788.Peer-Reviewed Original ResearchConceptsPhysical component summary scoreDecompression-alone groupSF-36 physical component summary scoreFusion groupSummary scoresDecompressive laminectomySpinal stenosisGrade IOutcome measuresSpinal fusionOswestry Disability Index scoresSymptomatic lumbar spinal stenosisPhysical health-related qualityDegenerative grade IStable degenerative spondylolisthesisLonger hospital stayMore blood lossOswestry Disability IndexDisability Index scoresSecondary outcome measuresHealth-related qualityMedical Outcomes StudyPosterolateral instrumented fusionPrimary outcome measureLumbar spinal stenosis
2015
The Effect of a Whey Protein Supplement on Bone Mass in Older Caucasian Adults
Kerstetter JE, Bihuniak JD, Brindisi J, Sullivan RR, Mangano KM, Larocque S, Kotler BM, Simpson CA, Cusano A, Gaffney-Stomberg E, Kleppinger A, Reynolds J, Dziura J, Kenny AM, Insogna KL. The Effect of a Whey Protein Supplement on Bone Mass in Older Caucasian Adults. The Journal Of Clinical Endocrinology & Metabolism 2015, 100: 2214-2222. PMID: 25844619, PMCID: PMC4454800, DOI: 10.1210/jc.2014-3792.Peer-Reviewed Original ResearchConceptsBone mineral densityBone resorptionL-spine bone mineral densitySelf-reported protein intakeDual-energy X-ray absorptiometryTruncal lean massPlacebo-controlled trialGlomerular filtration rateBody mass indexProtein supplementationC-terminal telopeptideX-ray absorptiometryFat-free massWhey protein supplementHigh-protein dietHealthy older adultsOlder Caucasian adultsUrine calciumRenal functionMass indexSkeletal healthUsual dietFiltration rateMineral densityBone mass
2014
Elevated CK-MB with a Normal Troponin Does Not Predict 30-Day Adverse Cardiac Events in Emergency Department Chest Pain Observation Unit Patients
Safdar B, Bezek SK, Sinusas AJ, Russell RR, Klein MR, Dziura JD, D’onofrio G. Elevated CK-MB with a Normal Troponin Does Not Predict 30-Day Adverse Cardiac Events in Emergency Department Chest Pain Observation Unit Patients. Critical Pathways In Cardiology A Journal Of Evidence-Based Medicine 2014, 13: 14-19. PMID: 24526146, DOI: 10.1097/hpc.0000000000000001.Peer-Reviewed Original ResearchConceptsAdverse cardiac eventsCPU patientsNormal troponinAdverse eventsCardiac eventsMultiple logistic regression modelComposite adverse eventsElevated creatinine kinaseObservation unit patientsSerial troponin testingStandardized chart reviewRetrospective cohort studyAcute coronary syndromeNational Death RegistryCoronary artery diseaseLogistic regression modelsPositive troponinPrior CADRenal insufficientCoronary syndromeHemodynamic instabilityChart reviewCohort studyDeath RegistryIschemic electrocardiogram
2013
Point-of-Care Focused Cardiac Ultrasound for Prediction of Pulmonary Embolism Adverse Outcomes
Taylor RA, Davis J, Liu R, Gupta V, Dziura J, Moore CL. Point-of-Care Focused Cardiac Ultrasound for Prediction of Pulmonary Embolism Adverse Outcomes. Journal Of Emergency Medicine 2013, 45: 392-399. PMID: 23827166, DOI: 10.1016/j.jemermed.2013.04.014.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overEchocardiographyEmergency Service, HospitalFemaleHemorrhageHospital MortalityHumansMaleMiddle AgedPoint-of-Care SystemsPredictive Value of TestsPrognosisPulmonary EmbolismRecurrenceRespiratory InsufficiencyRetrospective StudiesRisk FactorsShockVenous ThromboembolismVentricular Dysfunction, RightConceptsRight ventricular strainHospital adverse outcomesRetrospective chart reviewPulmonary embolismAdverse outcomesEmergency departmentChart reviewCardiac ultrasoundHighest positive likelihood ratioRecurrent venous thromboembolismLow negative likelihood ratioSignificant predictorsEmergency care practitionersFocused cardiac ultrasoundFOCUS examinationPositive likelihood ratioNegative likelihood ratioMajor bleedingLikelihood ratioRespiratory failureVenous thromboembolismTransthoracic echocardiographyHospital admissionIndependent predictorsVentricular strain
2012
Comparison of the Effect on Long-Term Outcomes in Patients With Thoracic Aortic Aneurysms of Taking Versus Not Taking a Statin Drug
Jovin IS, Duggal M, Ebisu K, Paek H, Oprea AD, Tranquilli M, Rizzo J, Memet R, Feldman M, Dziura J, Brandt CA, Elefteriades JA. Comparison of the Effect on Long-Term Outcomes in Patients With Thoracic Aortic Aneurysms of Taking Versus Not Taking a Statin Drug. The American Journal Of Cardiology 2012, 109: 1050-1054. PMID: 22221941, DOI: 10.1016/j.amjcard.2011.11.038.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmLong-term outcomesComposite end pointAortic aneurysmAneurysm repairEnd pointImproved long-term outcomesOutcomes of patientsCohort of patientsKaplan-Meier analysisMedian followStatin intakeStatin therapyMedical therapyStatinsFirst presentationPatientsSurvival rateAneurysmsStatin drugsOutcomesTherapyIntakeRepairCohort
2011
Endoscopic Ultrasound and Endoscopic Retrograde Cholangiopancreatography for Obstructing Pancreas Head Masses
Aslanian HR, Estrada JD, Rossi F, Dziura J, Jamidar PA, Siddiqui UD. Endoscopic Ultrasound and Endoscopic Retrograde Cholangiopancreatography for Obstructing Pancreas Head Masses. Journal Of Clinical Gastroenterology 2011, 45: 711-713. PMID: 21301359, DOI: 10.1097/mcg.0b013e3182045923.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnesthesia, GeneralBiopsy, Fine-NeedleChi-Square DistributionCholangiopancreatography, Endoscopic RetrogradeConnecticutConscious SedationDrainageEndosonographyFeasibility StudiesHumansJaundice, ObstructiveMiddle AgedPancreatic NeoplasmsPredictive Value of TestsRetrospective StudiesStentsTime FactorsTreatment OutcomeConceptsEndoscopic retrograde cholangiopancreatographyEndoscopic ultrasoundFine-needle aspirationObstructive jaundiceRetrograde cholangiopancreatographyStent placementEUS-FNAEUS-guided fine-needle aspirationPancreas head massTertiary referral hospitalBiliary stent placementEUS-FNA diagnosisDiagnostic EUS-FNAPlacement success rateOnly complicationReferral hospitalSedative medicationsBiliary stentingConsecutive patientsMedian timePatient evaluationERCP proceduresSame sedationProcedure durationProcedure lengthComparative Effectiveness of Ventral vs Dorsal Surgery for Cervical Spondylotic Myelopathy
Ghogawala Z, Martin B, Benzel EC, Dziura J, Magge SN, Abbed KM, Bisson EF, Shahid J, Coumans JV, Choudhri TF, Steinmetz MP, Krishnaney AA, King JT, Butler WE, Barker FG, Heary RF. Comparative Effectiveness of Ventral vs Dorsal Surgery for Cervical Spondylotic Myelopathy. Neurosurgery 2011, 68: 622-631. PMID: 21164373, DOI: 10.1227/neu.0b013e31820777cf.Peer-Reviewed Original ResearchConceptsCervical spondylotic myelopathyFusion surgeryVentral surgeryHospital staySpondylotic myelopathyHR-QOLClinical trialsHospital costsDegenerative cervical spondylotic myelopathyJapanese Orthopaedic Association scale scoreModified Japanese Orthopaedic Association scale scorePilot studyHR-QOL improvementMean hospital costDisease-specific symptomsHealth-related qualityClinical pilot trialPatients age 40Spinal cord dysfunctionHigher hospital costsRandomized clinical trialsDorsal surgeryBaseline demographicsComplication rateCord dysfunction
2009
Specific Relation Between Abdominal Obesity and Early-Phase Hyperglycemia Is Modulated by Hepatic Insulin Resistance in Healthy Older Women
DiPietro L, Dziura J, Yeckel CW. Specific Relation Between Abdominal Obesity and Early-Phase Hyperglycemia Is Modulated by Hepatic Insulin Resistance in Healthy Older Women. Diabetes Care 2009, 33: 165-167. PMID: 19808930, PMCID: PMC2797964, DOI: 10.2337/dc09-1365.Peer-Reviewed Original ResearchConceptsHepatic insulin resistanceOral glucose tolerance testAbdominal obesityGlucose tolerance testHealthy older womenInsulin resistanceOlder womenTolerance testLow-dose insulin infusionHepatic glucose productionGlucose excursionsInsulin infusionPlasma glucoseAbdominal circumferenceInsulin concentrationsInsulin suppressionMin postchallengeObesityGlycemic responseClamp techniqueGlucose productionWomenHyperglycemiaProduction suppressionPostchallenge
2008
Progressive improvement in glucose tolerance following lower-intensity resistance versus moderate-intensity aerobic training in older women.
Dipietro L, Yeckel CW, Dziura J. Progressive improvement in glucose tolerance following lower-intensity resistance versus moderate-intensity aerobic training in older women. Journal Of Physical Activity And Health 2008, 5: 854-69. PMID: 19164820, DOI: 10.1123/jpah.5.6.854.Peer-Reviewed Original ResearchConceptsOral glucose tolerance testFree fatty acidsGlucose toleranceOlder womenFFA concentrationsModerate-intensity aerobic trainingBasal FFA concentrationLight resistance trainingModerate-intensity aerobicLast exercise sessionGlucose tolerance testInactive older womenResistance training groupLevels of FFALow-intensity resistanceTolerance testPlasma glucoseAerobic trainingExercise sessionsSerial improvementInsulin actionOlder peopleTraining groupProgressive improvementGlucose concentration
2005
Patterns of reduced nipple aspirate fluid production and ductal lavage cellularity in women at high risk for breast cancer
Higgins SA, Matloff ET, Rimm DL, Dziura J, Haffty BG, King BL. Patterns of reduced nipple aspirate fluid production and ductal lavage cellularity in women at high risk for breast cancer. Breast Cancer Research 2005, 7: r1017. PMID: 16280052, PMCID: PMC1410733, DOI: 10.1186/bcr1335.Peer-Reviewed Original ResearchConceptsHigh-risk womenFluid-yielding ductsPrevious multicenter trialsMulticenter trialBreast cancerDuctal lavageLavage cellularityPresent seriesNAF productionSelective estrogen receptor modulatorsRisk-reducing therapiesRisk reduction therapyBRCA germline mutationsEstrogen receptor modulatorsBRCA-positive womenBreast cancer developmentEvaluation of abnormalitiesPostmenopausal statusHealthy womenBreast fluidIntraductal approachReceptor modulatorsRelative riskDuctal orificeReduction therapyExercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training
DiPietro L, Dziura J, Yeckel CW, Neufer PD. Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training. Journal Of Applied Physiology 2005, 100: 142-149. PMID: 16141382, DOI: 10.1152/japplphysiol.00474.2005.Peer-Reviewed Original ResearchConceptsHigh-intensity exercise trainingIntensity exercise trainingExercise trainingAerobic trainingInsulin sensitivityExercise volumeOlder womenGlucose utilizationModerate-intensity aerobic trainingTwo-step euglycemic-hyperinsulinemic clampInsulin-stimulated glucose utilizationHigh-intensity aerobic trainingDual-energy X-ray absorptiometryHigher insulin doseLower insulin doseHealthy older womenEuglycemic hyperinsulinemic clampLow-intensity exerciseTotal body fatAdipose tissue lipolysisImproved glucose utilizationX-ray absorptiometrySuppression of lipolysisFinal exercise boutInsulin-stimulated suppression
2004
Patients with uterine papillary serous cancers may benefit from adjuvant platinum-based chemoradiation
Kelly MG, O'Malley D, Hui P, McAlpine J, Dziura J, Rutherford TJ, Azodi M, Chambers SK, Schwartz PE. Patients with uterine papillary serous cancers may benefit from adjuvant platinum-based chemoradiation. Gynecologic Oncology 2004, 95: 469-473. PMID: 15581948, DOI: 10.1016/j.ygyno.2004.08.030.Peer-Reviewed Original ResearchConceptsUterine papillary serous carcinomaStage IA patientsResidual uterine diseaseAdvanced stage uterine papillary serous carcinomaIA patientsUterine diseaseSerous cancerUterine papillary serous cancerComplete surgical stagingObstetrics stage IAPapillary serous cancerDifferent therapeutic optionsPapillary serous carcinomaPlatinum-based chemoradiationMore effective treatmentsLocoregional diseaseHysterectomy specimenStage IAStage IIIAStage IIICSurgical stagingExtrauterine metastasesSerous carcinomaTherapeutic optionsFallopian tube
2003
Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance
Petersen KF, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman DL, DiPietro L, Cline GW, Shulman GI. Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance. Science 2003, 300: 1140-1142. PMID: 12750520, PMCID: PMC3004429, DOI: 10.1126/science.1082889.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdolescentAdultAgedAged, 80 and overAgingBlood GlucoseBody Mass IndexFemaleHumansInsulinInsulin ResistanceLiverMaleMiddle AgedMitochondriaMitochondrial DiseasesMuscle, SkeletalNuclear Magnetic Resonance, BiomolecularOxidation-ReductionOxygen ConsumptionPhosphorylationTriglyceridesConceptsInsulin resistanceInsulin-stimulated muscle glucose metabolismType 2 diabetesMuscle glucose metabolismLean body massElderly study participantsAge-associated declineMitochondrial function contributesFat massFat accumulationGlucose metabolismYoung controlsStudy participantsLiver tissueFunction contributesMitochondrial dysfunctionYounger participantsPossible roleMitochondrial oxidativeBody massMagnetic resonance spectroscopyParticipantsDiabetesDysfunctionPathogenesis