2020
Validating Self‐Reported Unhealthy Alcohol Use With Phosphatidylethanol (PEth) Among Patients With HIV
Eyawo O, Deng Y, Dziura J, Justice AC, McGinnis K, Tate JP, Rodriguez‐Barradas M, Hansen NB, Maisto SA, Marconi VC, O’Connor P, Bryant K, Fiellin DA, Edelman EJ. Validating Self‐Reported Unhealthy Alcohol Use With Phosphatidylethanol (PEth) Among Patients With HIV. Alcohol Clinical And Experimental Research 2020, 44: 2053-2063. PMID: 33460225, PMCID: PMC8856627, DOI: 10.1111/acer.14435.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useSignificant alcohol useHeavy drinking daysAlcohol use disorderTimeline FollowbackAlcohol useSelf-reported alcohol useNumber of drinksClinical trialsRisk drinkingUse disordersDrinking daysBiomarker-based evidenceSample of PWHDrinks/dayMean numberSelf-reported alcohol consumptionMagnitude of associationBlood spot samplesLiver diseasePEth levelsTLFB interviewAlcohol consumptionLogistic regressionPatients
2015
The influence of clopidogrel on ischemia diagnosed by myocardial perfusion stress testing
Jovin IS, Ebisu KA, Oprea AD, Brandt CA, Natale D, Finta LA, Dziura J, Wackers FJ. The influence of clopidogrel on ischemia diagnosed by myocardial perfusion stress testing. Journal Of Nuclear Cardiology 2015, 23: 773-779. PMID: 26338428, DOI: 10.1007/s12350-015-0268-3.Peer-Reviewed Original ResearchConceptsReversible perfusion defectsOdds ratioPerfusion defectsMyocardial perfusion stress testMyocardial perfusion stress testingStress testStress myocardial perfusion scansMyocardial single photon emissionAdenosine stress testInfluence of clopidogrelLikelihood of ischemiaMyocardial perfusion testingUse of clopidogrelCoronary vascular toneExercise stress testMyocardial perfusion scanMyocardial perfusion imagingSingle photon emissionAdenosine receptor antagonistDiagnosis of ischemiaPerfusion scanPerfusion testingVascular toneReceptor antagonistTomography scan
2014
Using Multiple Daily Pain Ratings to Improve Reliability and Assay Sensitivity: How Many Is Enough?
Heapy A, Dziura J, Buta E, Goulet J, Kulas JF, Kerns RD. Using Multiple Daily Pain Ratings to Improve Reliability and Assay Sensitivity: How Many Is Enough? Journal Of Pain 2014, 15: 1360-1365. PMID: 25283469, DOI: 10.1016/j.jpain.2014.09.012.Peer-Reviewed Original ResearchConceptsPain intensity ratingsPain treatment trialsPain ratingsTreatment trialsIntensity ratingsDaily pain ratingsMedical Center patientsIMMPACT recommendationsBaseline measurement periodCenter patientsPain assessmentBland-Altman analysisClinical trialsSecondary data analysisDaily callsDaily ratingsTrialsMeaningful differencesAssay sensitivityMeasure reliabilityAdequate reliabilitySpecific recommendationsPatientsSmall subsetBaselineNormal Pediatric Data for Isovolumic Acceleration at the Lateral Tricuspid Valve Annulus—A Heart Rate – Dependent Measure of Right Ventricular Contractility
Weismann CG, Bamdad MC, Abraham S, Ghiroli S, Dziura J, Hellenbrand WE. Normal Pediatric Data for Isovolumic Acceleration at the Lateral Tricuspid Valve Annulus—A Heart Rate – Dependent Measure of Right Ventricular Contractility. Echocardiography 2014, 32: 541-547. PMID: 25039533, DOI: 10.1111/echo.12681.Peer-Reviewed Original ResearchMeSH KeywordsAccelerationAgingChildConnecticutEchocardiographyElasticity Imaging TechniquesFemaleHeart RateHeart VentriclesHumansImage EnhancementImage Interpretation, Computer-AssistedMaleReference ValuesReproducibility of ResultsSensitivity and SpecificityTricuspid ValveVentricular Function, RightConceptsTricuspid annular plane systolic excursionBody surface areaHeart rateIsovolumic contractionAnnular plane systolic excursionRight ventricular functionRight ventricular contractilityManagement of patientsLateral tricuspid valve annulusCongenital heart diseaseTricuspid valve annulusIsovolumic accelerationRV contractilityRV dysfunctionSystolic excursionRV SEchocardiographic measuresVentricular functionNormal echocardiogramRetrospective studyVentricular contractilityPediatric dataTissue DopplerHeart diseaseValve annulusEthyl Glucuronide and Ethyl Sulfate Assays in Clinical Trials, Interpretation, and Limitations: Results of a Dose Ranging Alcohol Challenge Study and 2 Clinical Trials
Jatlow PI, Agro A, Wu R, Nadim H, Toll BA, Ralevski E, Nogueira C, Shi J, Dziura JD, Petrakis IL, O'Malley SS. Ethyl Glucuronide and Ethyl Sulfate Assays in Clinical Trials, Interpretation, and Limitations: Results of a Dose Ranging Alcohol Challenge Study and 2 Clinical Trials. Alcohol Clinical And Experimental Research 2014, 38: 2056-2065. PMID: 24773137, PMCID: PMC4107122, DOI: 10.1111/acer.12407.Peer-Reviewed Original ResearchConceptsEtG/EtSClinical trialsEthyl glucuronideRecent alcohol consumptionEvaluation of outcomesAlcohol challenge studyBlood concentrationsAlcohol dosesLow doseLight drinkingAlcohol consumptionChallenge studiesCutoff concentrationDrinking historyTimed intervalsAbstinenceTrialsHeavy consumptionDrinkingDoseGlucuronideObjective measuresHoursCutoffEtG
2012
Point‐of‐care Focused Cardiac Ultrasound for the Assessment of Thoracic Aortic Dimensions, Dilation, and Aneurysmal Disease
Taylor RA, Oliva I, Van Tonder R, Elefteriades J, Dziura J, Moore CL. Point‐of‐care Focused Cardiac Ultrasound for the Assessment of Thoracic Aortic Dimensions, Dilation, and Aneurysmal Disease. Academic Emergency Medicine 2012, 19: 244-247. PMID: 22288871, DOI: 10.1111/j.1553-2712.2011.01279.x.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmAortic dilationThoracic aortic dimensionsCT angiographyTransthoracic echocardiographyAortic dissectionBland-Altman plotsAortic dimensionsEmergency departmentAortic aneurysmEmergency physiciansCardiac ultrasoundPilot studyNinety-two patientsThoracic aorta pathologyFurther prospective studiesThoracic aortic diameterThoracic aortic pathologyRetrospective pilot studySinus of ValsalvaAcademic emergency departmentCTA measurementsFocused cardiac ultrasoundRetrospective pilot analysisReference standard
2006
Ethnic differences in beta cell adaptation to insulin resistance in obese children and adolescents
Weiss R, Dziura JD, Burgert TS, Taksali SE, Tamborlane WV, Caprio S. Ethnic differences in beta cell adaptation to insulin resistance in obese children and adolescents. Diabetologia 2006, 49: 571-579. PMID: 16456682, DOI: 10.1007/s00125-005-0109-z.Peer-Reviewed Original ResearchConceptsEarly insulin responseObese childrenInsulin resistanceInsulin clearanceInsulin responseAims/hypothesisThe prevalenceObesity-related insulin resistanceOral glucose loadLower insulin clearanceType 2 diabetesAcute insulin responseGlucose tolerance levelsAltered glucose metabolismSevere insulin resistanceBeta-cell adaptationAfrican American subjectsEthnic groupsHypothesisThe prevalenceGlucose toleranceGlucose loadInsulin sensitivityGlucose metabolismMethodsSeven hundredClearanceHispanic origin
2004
Experience with the continuous glucose monitoring system in a medical intensive care unit.
Goldberg PA, Siegel MD, Russell RR, Sherwin RS, Halickman JI, Cooper DA, Dziura JD, Inzucchi SE. Experience with the continuous glucose monitoring system in a medical intensive care unit. Diabetes Technology & Therapeutics 2004, 6: 339-47. PMID: 15198837, DOI: 10.1089/152091504774198034.Peer-Reviewed Original ResearchConceptsIntensive care unitMedical intensive care unitIll patientsContinuous glucose monitoring systemMedical ICUGlucose monitoring systemGlycemic excursionsCare unitStrict glycemic controlRole of hyperglycemiaBlood glucose levelsMICU patientsDiabetes mellitusGlycemic controlICU patientsClinical outcomesNursing workloadInpatient settingGlucose levelsPatientsStudy subjectsLarger studyBG readingsSES differencesFrequent monitoring