2008
Effect of Acute and Recurrent Hypoglycemia on Changes in Brain Glycogen Concentration
Herzog RI, Chan O, Yu S, Dziura J, McNay EC, Sherwin RS. Effect of Acute and Recurrent Hypoglycemia on Changes in Brain Glycogen Concentration. Endocrinology 2008, 149: 1499-1504. PMID: 18187548, PMCID: PMC2276713, DOI: 10.1210/en.2007-1252.Peer-Reviewed Original ResearchConceptsHypoglycemia-associated autonomic failureRecurrent hypoglycemiaAcute hypoglycemiaAutonomic failureBrain glycogenGlycogen levelsBrain glucoseGlucose levelsRH groupInsulin-induced acute hypoglycemiaSimilar blood glucose levelsIntensive insulin treatmentHyperinsulinemic-hypoglycemic clamp studyBrain glycogen concentrationHypoglycemic clamp studiesBlood glucose levelsBrain glucose levelsCounterregulatory failureDiabetic patientsGlycogen supercompensationRecurrent episodesSingle boutInsulin treatmentClamp studiesAnimal models
2004
Experience with the continuous glucose monitoring system in a medical intensive care unit.
Goldberg PA, Siegel MD, Russell RR, Sherwin RS, Halickman JI, Cooper DA, Dziura JD, Inzucchi SE. Experience with the continuous glucose monitoring system in a medical intensive care unit. Diabetes Technology & Therapeutics 2004, 6: 339-47. PMID: 15198837, DOI: 10.1089/152091504774198034.Peer-Reviewed Original ResearchConceptsIntensive care unitMedical intensive care unitIll patientsContinuous glucose monitoring systemMedical ICUGlucose monitoring systemGlycemic excursionsCare unitStrict glycemic controlRole of hyperglycemiaBlood glucose levelsMICU patientsDiabetes mellitusGlycemic controlICU patientsClinical outcomesNursing workloadInpatient settingGlucose levelsPatientsStudy subjectsLarger studyBG readingsSES differencesFrequent monitoringImplementation of a Safe and Effective Insulin Infusion Protocol in a Medical Intensive Care Unit
Goldberg PA, Siegel MD, Sherwin RS, Halickman JI, Lee M, Bailey VA, Lee SL, Dziura JD, Inzucchi SE. Implementation of a Safe and Effective Insulin Infusion Protocol in a Medical Intensive Care Unit. Diabetes Care 2004, 27: 461-467. PMID: 14747229, DOI: 10.2337/diacare.27.2.461.Peer-Reviewed Original ResearchConceptsInsulin infusion protocolBlood glucose levelsGlucose levelsBlood glucose valuesIll patientsInfusion protocolMedical intensive care unit patientsGlucose valuesTarget blood glucose levelsMedical intensive care unitIntensive care unit patientsCare unit patientsSignificant adverse eventsIntensive care unitPrimary outcome measurementRelevant clinical variablesNarrow target rangeMICU nursesInsulin requirementsInsulin therapyUnit patientsAdverse eventsGlycemic controlCare unitClinical outcomes