2024
Digital spatial proteomic profiling reveals immune checkpoints as biomarkers in lymphoid aggregates and tumor microenvironment of desmoplastic melanoma
Su D, Schoenfeld D, Ibrahim W, Cabrejo R, Djureinovic D, Baumann R, Rimm D, Khan S, Halaban R, Kluger H, Olino K, Galan A, Clune J. Digital spatial proteomic profiling reveals immune checkpoints as biomarkers in lymphoid aggregates and tumor microenvironment of desmoplastic melanoma. Journal For ImmunoTherapy Of Cancer 2024, 12: e008646. PMID: 38519058, PMCID: PMC10961546, DOI: 10.1136/jitc-2023-008646.Peer-Reviewed Original ResearchConceptsCTLA-4 expression levelsCancer-associated fibroblastsAssociated with worse survivalExpression of immune checkpointsLAG-3 expressionDesmoplastic melanomaLymphoid aggregatesCTLA-4PD-1Immune checkpointsIntratumoral leukocytesLAG-3Tumor compartmentsWorse survivalCD20+B cellsIncreased expression of immune checkpointsProgrammed cell death protein 1Macrophage/monocyte markerSentinel lymph node positivityCell death protein 1Associated with poor prognosisLymph node positivityDense fibrous stromaPotential prognostic significanceCore of tumors
2023
The Facial Artery Perforator Flap
Lewis K, Islam S, Phillips S, Carney M, Clune J. The Facial Artery Perforator Flap. Journal Of Craniofacial Surgery 2023, 34: e434-e437. PMID: 36914599, DOI: 10.1097/scs.0000000000009249.Peer-Reviewed Original ResearchConceptsArtery perforator flapPerforator flapFacial artery perforator flapPositive marginsNasolabial foldsDonor site morbidityAverage followFinal pathologyLocal perforator flapsPathologic evidenceExcisional marginsRetrospective reviewNegative marginsPathology resultsImmediate reconstructionLess dissectionFlap elevationMelanoma casesAverage ageFacial arteryPatientsSite morbidityLarge flapNasal sidewallSenior author
2016
Functional Neck Dissection
Patel A, Clune J, Ariyan S. Functional Neck Dissection. Plastic & Reconstructive Surgery 2016, 138: 1084-1086. PMID: 27783008, DOI: 10.1097/prs.0000000000002705.Peer-Reviewed Original ResearchMalignant Melanoma
Pavri SN, Clune J, Ariyan S, Narayan D. Malignant Melanoma. Plastic & Reconstructive Surgery 2016, 138: 330e-340e. PMID: 27465194, DOI: 10.1097/prs.0000000000002367.Peer-Reviewed Original ResearchConceptsWide local excisionSentinel lymph node biopsyLymph node biopsySentinel lymphLocal excisionAuricular melanomaNode biopsyMedical therapyMetastatic melanomaSubungual melanomaMalignant melanomaDesmoplastic melanomaNational Comprehensive Cancer Network guidelinesIntermediate-thickness melanomasPostoperative radiation therapyGold standardHigh-risk lesionsCutaneous malignant melanomaFull-thickness skinThickness melanomaPregnant patientsInitial managementPreoperative lymphoscintigraphySurgical treatmentOngoing trials
2011
Surgical Reconstruction in Melanoma
Clune JE, Narayan D. Surgical Reconstruction in Melanoma. Current Problems In Cancer 2011, 35: 185-199. PMID: 21911182, DOI: 10.1016/j.currproblcancer.2011.07.006.Peer-Reviewed Original Research