2001
Analysis of Risk Factors for Fatal Rocky Mountain Spotted Fever: Evidence for Superiority of Tetracyclines for Therapy
Holman R, Paddock C, Curns A, Krebs J, McQuiston J, Childs J. Analysis of Risk Factors for Fatal Rocky Mountain Spotted Fever: Evidence for Superiority of Tetracyclines for Therapy. The Journal Of Infectious Diseases 2001, 184: 1437-1444. PMID: 11709786, DOI: 10.1086/324372.Peer-Reviewed Original ResearchConceptsRisk factorsFatal Rocky Mountain Spotted FeverRocky Mountain Spotted FeverOnset of symptomsCase fatality rateTetracycline-class antibioticsPrimary therapyClinical characteristicsOlder patientsAppropriate therapyRMSF casesNonfatal casesNational surveillanceHigh riskSpotted FeverPatientsEffective antibioticsTherapyDeathFeverAntibioticsTreatmentSymptomsFactorsDisease
2000
Survival of Ehrlichia chaffeensis in refrigerated, ADSOL‐treated RBCs
McKechnie D, Slater K, Childs J, Massung R, Paddock C. Survival of Ehrlichia chaffeensis in refrigerated, ADSOL‐treated RBCs. Transfusion 2000, 40: 1041-1047. PMID: 10988303, DOI: 10.1046/j.1537-2995.2000.40091041.x.Peer-Reviewed Original ResearchConceptsE. chaffeensisNucleated cellsTransfusion-acquired infectionEhrlichia chaffeensisMonocytic cell line THP-1Cell line THP-1Infected cell linesCytocentrifuged slidesTransfusion transmissionPacked RBC unitsPCR positivityE. chaffeensis DNASupernatant fractionCell culturesWeekly examinationsRBC unitsStudy designRBC productsTHP-1DH82 cellsPCR resultsCell linesChaffeensisInfectionSuccessful reisolation
1987
Prospective seroepidemiology of hantaviruses and population dynamics of small mammal communities of Baltimore, Maryland.
Childs J, Glass G, Korch G, LeDuc J. Prospective seroepidemiology of hantaviruses and population dynamics of small mammal communities of Baltimore, Maryland. American Journal Of Tropical Medicine And Hygiene 1987, 37: 648-62. PMID: 2891308, DOI: 10.4269/ajtmh.1987.37.648.Peer-Reviewed Original ResearchConceptsHigh IFA titersProspective seroepidemiological studyIndirect fluorescent antibody titersFluorescent antibody titersEvidence of transmissionTransmission of hantavirusesIndividual blood samplesAntibody titersSeroepidemiological studyIncidence rateAntibody prevalenceBlood samplesIFA titersMean incidenceRatsVirus transmissionHantavirusesMature animalsWhite-footed miceMiceTitersMonthsRodents