Isolation of the causative agent of hantavirus pulmonary syndrome.
Elliott L, Ksiazek T, Rollin P, Spiropoulou C, Morzunov S, Monroe M, Goldsmith C, Humphrey C, Zaki S, Krebs J, Maupin G, Gage K, Childs J, Nichol S, Peters C. Isolation of the causative agent of hantavirus pulmonary syndrome. American Journal Of Tropical Medicine And Hygiene 1994, 51: 102-8. PMID: 8059907, DOI: 10.4269/ajtmh.1994.51.102.Peer-Reviewed Original ResearchConceptsHantavirus pulmonary syndromePulmonary syndromeAcute respiratory illnessReverse transcriptase-polymerase chain reactionCausative agentTypical morphologic featuresConvalescent-phase seraTranscriptase-polymerase chain reactionUnknown hantavirusRespiratory illnessLung tissueHPS patientsVirus antigenEtiologic agentHigh mortalityMorphologic featuresIndirect immunofluorescenceGenus HantavirusVero cellsInfected cellsChain reactionRecent outbreakCell linesSyndromeDeer mice