1997
Extrahepatic biliary obstruction impairs microvascular perfusion and increases leukocyte adhesion in rat liver
Koeppel T, Trauner M, Baas J, Thies J, Schlosser S, Post S, Gebhard M, Herfarth C, Boyer J, Otto G. Extrahepatic biliary obstruction impairs microvascular perfusion and increases leukocyte adhesion in rat liver. Hepatology 1997, 26: 1085-1091. PMID: 9362346, DOI: 10.1002/hep.510260501.Peer-Reviewed Original ResearchConceptsBile duct ligationIntravital fluorescence microscopyHepatic microvascular perfusionAcute biliary obstructionMicrovascular perfusionLeukocyte adhesionBiliary obstructionIntercellular adhesion molecule-1 protein expressionLeukocyte-endothelial cell interactionsMale Wistar ratsHydrogen gas clearanceICAM-1 expressionSham-operated controlsRat liverWestern blot analysisSinusoidal perfusionNeutrophil infiltrationLiver injuryHepatic microcirculationLiver damageLiver microcirculationTissue immunofluorescenceDuct ligationWistar ratsMarked impairment
1989
Protein kinase C agonists inhibit bile secretion independently of effects on the microcirculation in the isolated perfused rat liver
Corasanti J, Smith N, Gordon E, Boyer J. Protein kinase C agonists inhibit bile secretion independently of effects on the microcirculation in the isolated perfused rat liver. Hepatology 1989, 10: 8-13. PMID: 2737605, DOI: 10.1002/hep.1840100103.Peer-Reviewed Original ResearchConceptsBile flowPerfusion pressureBile secretionVehicle dimethyl sulfoxideReversible decreaseConstant perfusate flowPhorbol dibutyrateVenous effluent concentrationsInactive phorbol ester 4Rat liver systemVascular redistributionHepatic microvasculaturePhorbol esterPhorbol ester 4Vasoactive agentsRole of hormonesPerfusate flowTrypan blue dyeAntagonist HProtein kinase C agonistsGm liverActive phorbol estersLiver systemRat liverOxygen consumption