2017
Mechanisms of bile acid mediated inflammation in the liver
Li M, Cai SY, Boyer JL. Mechanisms of bile acid mediated inflammation in the liver. Molecular Aspects Of Medicine 2017, 56: 45-53. PMID: 28606651, PMCID: PMC5662014, DOI: 10.1016/j.mam.2017.06.001.Peer-Reviewed Original ResearchConceptsLiver injuryBile acidsCholestatic animal modelsCauses of cholestasisCholestatic liver injuryInnate immune cellsBiliary injuryNeutrophil recruitmentBile flowImmune cellsEffective therapyInflammatory responseAnimal modelsMolecular mediatorsCholestasisInjuryNovel targetLiverElevated levelsPathological processesMolecular mechanismsHepatocytesInflammationPatientsPathogenesis
2010
Cholestasis: Genetic and Acquired
Boyer J. Cholestasis: Genetic and Acquired. Seminars In Liver Disease 2010, 30: 113-115. PMID: 20422493, DOI: 10.1055/s-0030-1253220.Peer-Reviewed Original ResearchConceptsBile salt export pumpCholestatic liver diseaseMultidrug resistance protein 3Cholestatic liver injuryLiver diseaseBile acidsBile salt transportersIssue of SeminarsLiver injuryCholestatic disordersBile flowSulfate conjugatesSodium taurocholate co-transporting polypeptideBile duct-cannulated animalsBile formationExport pumpProtein 3Bile acid-independent bile flowSalt transportersTaurocholate co-transporting polypeptideOrganic solute transporters alphaDependent bile salt transporterApical sodium-dependent bile salt transporterFamilial intrahepatic cholestasis-1Drug-induced cholestasis
2000
Induction of murine hepatocyte death by membrane‐bound CD95 (Fas/APO‐1)‐ligand: Characterization of an in Vitro system
Schlosser S, Azzaroli F, Dao T, Hingorani R, Crispe I, Boyer J. Induction of murine hepatocyte death by membrane‐bound CD95 (Fas/APO‐1)‐ligand: Characterization of an in Vitro system. Hepatology 2000, 32: 779-785. PMID: 11003622, DOI: 10.1053/jhep.2000.18422.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAnimalsApoptosisCell DeathFas Ligand ProteinFas ReceptorLiverMembrane GlycoproteinsMiceConceptsMouse hepatocytesMembrane-bound CD95LNIH 3T3 fibroblastsFas/APOProtein synthesis inhibitorPrimary mouse hepatocytesDNA strand breaksCultured mouse hepatocytesNuclear condensationAnti-CD95 antibodiesCell deathNuclear fragmentationBiochemical studiesStrand breaksCD95 ligandVitro systemCell apoptosisExposure of hepatocytesApoptosisCD95Potential targetCD95LSynthesis inhibitorCytoplasmic blebsLiver cell apoptosis
1998
Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo
Zheng T, Schlosser S, Dao T, Hingorani R, Crispe I, Boyer J, Flavell R. Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 13618-13623. PMID: 9811849, PMCID: PMC24868, DOI: 10.1073/pnas.95.23.13618.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAnimalsApoptosisCaspase 3CaspasesCell NucleusCytoplasmFas Ligand ProteinFas ReceptorLiverMembrane GlycoproteinsMiceRabbitsConceptsCell deathDNA fragmentationFas-induced cell deathCaspase-3-like activityTypical apoptotic featuresCaspase-3NIH 3T3 cellsDFF45/ICADCaspase substratesApoptotic caspasesCaspase-1Apoptotic eventsApoptotic featuresCaspasesMorphological changesAberrant apoptosisNuclear eventsKey substrateNuclear fragmentationHepatocyte cell deathCytoplasmic blebbingApoptosisDifferent morphological changesAltered cleavageFA