1997
Extrahepatic biliary obstruction impairs microvascular perfusion and increases leukocyte adhesion in rat liver
Koeppel T, Trauner M, Baas J, Thies J, Schlosser S, Post S, Gebhard M, Herfarth C, Boyer J, Otto G. Extrahepatic biliary obstruction impairs microvascular perfusion and increases leukocyte adhesion in rat liver. Hepatology 1997, 26: 1085-1091. PMID: 9362346, DOI: 10.1002/hep.510260501.Peer-Reviewed Original ResearchConceptsBile duct ligationIntravital fluorescence microscopyHepatic microvascular perfusionAcute biliary obstructionMicrovascular perfusionLeukocyte adhesionBiliary obstructionIntercellular adhesion molecule-1 protein expressionLeukocyte-endothelial cell interactionsMale Wistar ratsHydrogen gas clearanceICAM-1 expressionSham-operated controlsRat liverWestern blot analysisSinusoidal perfusionNeutrophil infiltrationLiver injuryHepatic microcirculationLiver damageLiver microcirculationTissue immunofluorescenceDuct ligationWistar ratsMarked impairment
1989
Protein kinase C agonists inhibit bile secretion independently of effects on the microcirculation in the isolated perfused rat liver
Corasanti J, Smith N, Gordon E, Boyer J. Protein kinase C agonists inhibit bile secretion independently of effects on the microcirculation in the isolated perfused rat liver. Hepatology 1989, 10: 8-13. PMID: 2737605, DOI: 10.1002/hep.1840100103.Peer-Reviewed Original ResearchConceptsBile flowPerfusion pressureBile secretionVehicle dimethyl sulfoxideReversible decreaseConstant perfusate flowPhorbol dibutyrateVenous effluent concentrationsInactive phorbol ester 4Rat liver systemVascular redistributionHepatic microvasculaturePhorbol esterPhorbol ester 4Vasoactive agentsRole of hormonesPerfusate flowTrypan blue dyeAntagonist HProtein kinase C agonistsGm liverActive phorbol estersLiver systemRat liverOxygen consumption
1982
Effect of Chlorpromazine on Hepatic Clearance and Excretion of Bile Acids by the Isolated Perfused Rat Liver 1
Tavoloni N, Reed J, Boyer J. Effect of Chlorpromazine on Hepatic Clearance and Excretion of Bile Acids by the Isolated Perfused Rat Liver 1. Experimental Biology And Medicine 1982, 170: 486-492. PMID: 7122478, DOI: 10.3181/00379727-170-41463.Peer-Reviewed Original ResearchConceptsBile acid excretionAcid excretionEffect of chlorpromazineBile acidsRat liverRat liver 1Glutamic oxalacetic transaminase activityHepatic perfusionHepatic functionTransaminase releasePerfusate concentrationPerfusate flowConstant infusionDrug AdministrationBile acid extractionControl liversHepatic clearanceGlutamic pyruvicTransaminase activityExcretionSodium taurocholateLiver 1Eventual excretionLiverChlorpromazineHemodynamic effects on oxygen consumption and bile flow in isolated skate liver
Reed J, Smith N, Boyer J. Hemodynamic effects on oxygen consumption and bile flow in isolated skate liver. American Journal Of Physiology 1982, 242: g313-g318. PMID: 7065253, DOI: 10.1152/ajpgi.1982.242.4.g313.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBileFishesKineticsLiverLiver CirculationOxygen ConsumptionPerfusionPressureSulfobromophthaleinTaurocholic AcidConceptsPerfusion pressureBile flowSkate liverOxygen consumptionOrganic anion clearanceBile flow ratePortal vein pressurePerfusion of liversHemodynamic effectsVein pressureBile secretionFractional disappearance rateHepatic clearanceLiverDisappearance rateRinger's solutionPerfusionBileClearanceTaurocholateRaja erinaceaSulfobromophthaleinVivoMammalian speciesPerfusate
1978
Hemodynamic effects on determinants of bile secretion in isolated rat liver.
Tavoloni N, Reed J, Boyer J. Hemodynamic effects on determinants of bile secretion in isolated rat liver. American Journal Of Physiology 1978, 234: e584. PMID: 665761, DOI: 10.1152/ajpendo.1978.234.6.e584.Peer-Reviewed Original Research
1974
Variation in hepatic bile composition following cholecystectomy in patients with previous gallstones.
Boyer J, Bloomer J, Maddrey W, Tilson D. Variation in hepatic bile composition following cholecystectomy in patients with previous gallstones. The Yale Journal Of Biology And Medicine 1974, 47: 211-7. PMID: 4456833, PMCID: PMC2595121.Peer-Reviewed Original ResearchConceptsHepatic bileBile compositionEnterohepatic circulationBile acidsBile acid poolLithogenicity of bileHepatic bile compositionBile specimensDay study periodT-tubeCholesterol gallstonesPatientsExcretion rateCholecystectomyBileStudy periodGallstonesAcid poolAdmirandGallbladderLithogenicityCirculationHepatic Injury from Chronic Hypervitaminosis a Resulting in Portal Hypertension and Ascites
Russell R, Boyer J, Bagheri S, Hruban Z. Hepatic Injury from Chronic Hypervitaminosis a Resulting in Portal Hypertension and Ascites. New England Journal Of Medicine 1974, 291: 435-440. PMID: 4843409, DOI: 10.1056/nejm197408292910903.Peer-Reviewed Original ResearchMeSH KeywordsAscitesBasement MembraneBiopsy, NeedleChemical and Drug Induced Liver InjuryCollagenFemaleHepatic VeinsHistocytochemistryHumansHypertension, PortalLipid MetabolismLiverLiver CirculationLiver CirrhosisMaleMicroscopy, ElectronMicroscopy, FluorescenceMiddle AgedSclerosisTime FactorsVitamin AConceptsPortal hypertensionHepatic blood flowChronic hypervitaminosis ALiver biopsy materialLipid storage cellsChronic hypervitaminosisFocal congestionVein sclerosisHepatic injuryPerisinusoidal fibrosisHypervitaminosis AChronic ingestionHepatic functionClinical signsHistologic examinationBlood flowUnusual lesionFrozen sectionsIto cellsPerisinusoidal spaceCirrhosisHypertensionAscitesVitaminLike material