1987
Improved survival with primary sclerosing cholangitis A review of clinicopathologic features and comparison of symptomatic and asymptomatic patients
Helzberg J, Petersen J, Boyer J. Improved survival with primary sclerosing cholangitis A review of clinicopathologic features and comparison of symptomatic and asymptomatic patients. Gastroenterology 1987, 92: 1869-1875. PMID: 3569762, DOI: 10.1016/0016-5085(87)90618-4.Peer-Reviewed Original ResearchConceptsPrimary sclerosing cholangitisIntrahepatic ductal systemSclerosing cholangitisClinicopathologic featuresDuctal systemKaplan-Meier life-table analysisLong-term prognosisGroup of patientsDifferent clinical characteristicsSerum bilirubin levelsOnset of diseaseUniversity Medical CenterLife-table analysisBiliary sclerosisAsymptomatic patientsPortal hypertensionClinical characteristicsLiver centersBilirubin levelsClinical featuresLiver diseaseMild diseasePoor prognosisMean ageFemale ratio
1985
Asymptomatic primary biliary cirrhosis A progress report on long-term follow-up and natural history
Beswick D, Klatskin G, Boyer J. Asymptomatic primary biliary cirrhosis A progress report on long-term follow-up and natural history. Gastroenterology 1985, 89: 267-271. PMID: 4007417, DOI: 10.1016/0016-5085(85)90325-7.Peer-Reviewed Original ResearchConceptsAsymptomatic primary biliary cirrhosisPrimary biliary cirrhosisBiliary cirrhosisAsymptomatic stateGeneral populationInitial liver biopsySubgroup of patientsLife table survival analysisDevelopment of symptomsMedian followPortal granulomasOverall survivalProgressive diseaseLiver biopsyLiver diseaseMedian periodAutoimmune disordersExtended followHistologic featuresBenign outcomeCirrhosisPatientsSurvival analysisNatural historySymptoms
1983
The Prognostic Importance of Clinical and Histologic Features in Asymptomatic and Symptomatic Primary Biliary Cirrhosis
Roll J, Boyer J, Barry D, Klatskin G. The Prognostic Importance of Clinical and Histologic Features in Asymptomatic and Symptomatic Primary Biliary Cirrhosis. New England Journal Of Medicine 1983, 308: 1-7. PMID: 6847917, DOI: 10.1056/nejm198301063080101.Peer-Reviewed Original ResearchConceptsPrimary biliary cirrhosisBiliary cirrhosisPoor prognosisSymptomatic primary biliary cirrhosisOnset of diseaseAsymptomatic patientsAsymptomatic diseaseClinical featuresHistologic featuresHistologic stagePrediction of riskPrognostic importanceSerum bilirubinHepatic fibrosisHistologic findingsPortal areasProlonged survivalMultivariate analysisPatientsControl populationPrognosisWeight lossElevated levelsLife expectancySurvival data