1989
Determinants of glutathione efflux and biliary GSH/GSSG ratio in perfused rat liver
Ballatori N, Truong A, K. A, Boyer J. Determinants of glutathione efflux and biliary GSH/GSSG ratio in perfused rat liver. American Journal Of Physiology 1989, 256: g482-g490. PMID: 2564253, DOI: 10.1152/ajpgi.1989.256.3.g482.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBileFluorocarbonsGamma-GlutamyltransferaseGlutathioneGlutathione DisulfideIn Vitro TechniquesIsoxazolesKineticsLiverMalePerfusionRatsRats, Inbred StrainsConceptsGamma-glutamyl transferase activityO2 deliveryBiliary glutathioneHepatic effluxSinusoidal effluxKrebs-Ringer bicarbonate bufferGlutathione effluxRat liverEfflux of glutathioneGSH/GSSG ratioRed blood cellsPerfusion flow rateFluorocarbon emulsionsBile flowTissue GSHOxygen deliveryTransferase activityAT-125LiverBovine red blood cellsPerfusate compositionBlood cellsBileGSSG levelsGSSG ratio
1988
Biliary catabolism of glutathione and differential reabsorption of its amino acid constituents
Ballatori N, Jacob R, Barrett C, Boyer J. Biliary catabolism of glutathione and differential reabsorption of its amino acid constituents. American Journal Of Physiology 1988, 254: g1-g7. PMID: 2892423, DOI: 10.1152/ajpgi.1988.254.1.g1.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptionAmino AcidsAnimalsBileDogsGamma-GlutamyltransferaseGlutathioneGuinea PigsIsoxazolesLiverOsmolar ConcentrationRabbitsConceptsGuinea pigsBile samplesAT-125Biliary glutathione excretionControl bile samplesHepatic gamma-glutamyltransferase activityCatabolism of glutathioneTotal amino acidsGamma-glutamyltransferase activityBiliary treePentobarbital sodiumBiliary excretionHepatic bileAmino acid conjugationGlutathione excretionRetrograde intrabiliary infusionBileConcentration of glutathioneFree amino acidsTotal glutamateConstituent amino acidsMarked increaseUndetectable levelsAcid conjugationDogs
1986
Intrabiliary glutathione hydrolysis. A source of glutamate in bile.
Ballatori N, Jacob R, Boyer J. Intrabiliary glutathione hydrolysis. A source of glutamate in bile. Journal Of Biological Chemistry 1986, 261: 7860-7865. PMID: 2872220, DOI: 10.1016/s0021-9258(19)57482-8.Peer-Reviewed Original ResearchConceptsGamma-glutamyl transferase activityBiliary excretionRat bileRetrograde intrabiliary infusionAT-125Normal male Sprague-DawleyAdministration of phenolMale Sprague-DawleyNormal rat bileDihydro-5-isoxazoleacetic acidSource of glutamateIntrabiliary infusionRate of excretionDibromphthalein disulfonateBranched chain amino acids valineBiliary treeSprague-DawleyDiethyl maleateBileExcretionTransferase activityGSH secretionLiver cellsMarked decreaseExcretion of glutamate