1999
Hepatic Toxicity and Persistence of ser/thr Protein Phosphatase Inhibition by Microcystin in the Little Skate Raja erinacea
Runnegar M, Seward D, Ballatori N, Crawford J, Boyer J. Hepatic Toxicity and Persistence of ser/thr Protein Phosphatase Inhibition by Microcystin in the Little Skate Raja erinacea. Toxicology And Applied Pharmacology 1999, 161: 40-49. PMID: 10558922, DOI: 10.1006/taap.1999.8783.Peer-Reviewed Original ResearchConceptsDose-dependent inhibitionSkate hepatocytesUptake of microcystinNear complete inhibitionPP activityInflammatory changesHepatic toxicityHepatocyte necrosisHistological changesAccompanying inhibitionHepatic lesionsBile acidsHigh dosesOnly organSignificant inhibitionSkate Raja erinaceaLittle skate Raja erinaceaInhibitionLiverRectal glandVasoactive intestinal polypeptide is a potent regulator of bile secretion from rat cholangiocytes
Cho W, Boyer J. Vasoactive intestinal polypeptide is a potent regulator of bile secretion from rat cholangiocytes. Gastroenterology 1999, 117: 420-428. PMID: 10419925, DOI: 10.1053/gast.1999.0029900420.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBileBile DuctsCyclic AMPDose-Response Relationship, DrugMaleMolecular Sequence DataPerfusionRatsRats, Sprague-DawleyReceptors, Vasoactive Intestinal PeptideVasoactive Intestinal PeptideConceptsBile duct unitsEffect of VIPBile flowBile secretionDuct unitsIntestinal polypeptideFluid secretionBile duct-ligated ratsBile salt outputVasoactive intestinal polypeptideHepatocyte coupletsDose-dependent increaseDuct-ligated ratsBile pHVIP antagonistSite of actionSubstance PSecretory responseVIP responsesReceptor inhibitorsCAMP-independent pathwayBicarbonate secretionPotent stimulantSalt outputAbstractText
1990
Modulation of Na+/alanine cotransport in liver sinusoidal membrane vesicles by internal divalent cations
Simmons T, Moseley R, Boyer J, Ballatori N. Modulation of Na+/alanine cotransport in liver sinusoidal membrane vesicles by internal divalent cations. Biochimica Et Biophysica Acta 1990, 1023: 462-468. PMID: 2110482, DOI: 10.1016/0005-2736(90)90140-j.Peer-Reviewed Original ResearchAlanineAnimalsBiological TransportCalciumCell MembraneDose-Response Relationship, DrugEdetic AcidEgtazic AcidLiverMagnesiumManganeseRatsSodiumTime Factors
1988
Characteristics of L-alanine uptake in freshly isolated hepatocytes of elasmobranch Raja erinacea
Ballatori N, Boyer J. Characteristics of L-alanine uptake in freshly isolated hepatocytes of elasmobranch Raja erinacea. American Journal Of Physiology 1988, 254: r801-r808. PMID: 3364608, DOI: 10.1152/ajpregu.1988.254.5.r801.Peer-Reviewed Original ResearchMeSH KeywordsAlanineAminoisobutyric AcidsAminooxyacetic AcidAnimalsBileBiological Transport, ActiveDose-Response Relationship, DrugGlucagonGluconeogenesisGlutathioneLiverMaleSkates, FishConceptsNeutral amino acid transport systemElasmobranch Raja erinaceaMajor gluconeogenic precursorMM alanineSodium-dependent systemAmino acid transport systemsRaja erinaceaHepatic uptakeHepatic concentrationsAcid transport systemL-alanine uptakeAminotransferase activityTumor cellsSpecific transport mechanismsMeAIB transportGluconeogenic precursorsSaturable mechanismSkate hepatocytesHepatocytesAlanine metabolismGlucose releaseMeAIBHepatocyte suspensionsRat hepatocytesUptake
1986
Sodium gradient-dependent L-glutamate transport is localized to the canalicular domain of liver plasma membranes. Studies in rat liver sinusoidal and canalicular membrane vesicles.
Ballatori N, Moseley R, Boyer J. Sodium gradient-dependent L-glutamate transport is localized to the canalicular domain of liver plasma membranes. Studies in rat liver sinusoidal and canalicular membrane vesicles. Journal Of Biological Chemistry 1986, 261: 6216-6221. PMID: 2871024, DOI: 10.1016/s0021-9258(19)84550-7.Peer-Reviewed Original Research
1985
The effect of ethanol and calcium on fluid state of plasma membranes of rat hepatocytes
Mills P, Meier P, Boyer J, Gordon E. The effect of ethanol and calcium on fluid state of plasma membranes of rat hepatocytes. Alcohol 1985, 2: 153-156. PMID: 4015830, DOI: 10.1016/0741-8329(85)90034-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumDose-Response Relationship, DrugEthanolIn Vitro TechniquesLiverMembrane FluidityRatsTaurocholic AcidConceptsMembrane protein functionProtein functionMembrane fluidityCanalicular plasma membrane vesiclesPlasma membrane vesiclesOverall cellular activityMembrane lipid fluidityPlasma membraneMembrane preparationsMembrane vesiclesCellular activitiesImportant regulatorLipid fluidityMembrane perturbantsFluorescence polarizationRat hepatocytesFluidityBlLPMRegulatorUptakeUptake of taurocholateVesiclesMillipore filtration technique
1979
Chlorpromazine and Its Metabolites Alter Polymerization and Gelation of Actin
Elias E, Boyer J. Chlorpromazine and Its Metabolites Alter Polymerization and Gelation of Actin. Science 1979, 206: 1404-1406. PMID: 574316, DOI: 10.1126/science.574316.Peer-Reviewed Original ResearchActinsAnimalsChlorpromazineCytoskeletonDose-Response Relationship, DrugGelsProtein BindingRabbitsViscosity
1978
Stimulation of thymidine incorporation in mouse liver and biliary tract epithelium by lithocholate and deoxycholate
Bagheri S, Bolt M, Boyer J, Palmer R. Stimulation of thymidine incorporation in mouse liver and biliary tract epithelium by lithocholate and deoxycholate. Gastroenterology 1978, 74: 188-192. PMID: 620891, DOI: 10.1016/0016-5085(78)90793-x.Peer-Reviewed Original ResearchConceptsCertain bile acidsBiliary tractBile acidsBiliary tract epitheliumSingle oral dosesBile duct hyperplasiaBile acid poolBile saltsDuctular cell hyperplasiaPeliosis hepatisOral dosesHepatocellular necrosisBile ductCell hyperplasiaDuct hyperplasiaEnterohepatic circulationHepatic nodulesProliferative activityThymidine incorporationLiverEarly effectsLithocholateMouse liverDosesCell kinetics