2021
Role of Biliary Organoids in Cholestasis Research and Regenerative Medicine
Soroka CJ, Roberts SJ, Boyer JL, Assis DN. Role of Biliary Organoids in Cholestasis Research and Regenerative Medicine. Seminars In Liver Disease 2021, 41: 206-212. PMID: 33957696, DOI: 10.1055/s-0041-1728663.Peer-Reviewed Original ResearchConceptsHuman cholestatic diseasesCholestatic diseaseBiliary organoidsStudy of pathophysiologyCholestasis ResearchBiliary treeDisease stageIndividual patientsTranslational studiesPrimary cholangiocytesPersonalized approachBiliary tissueApplication of organoidsStandardization of terminologyTranslational medicineDiseaseOrganoidsMedicineOrganoid technologyPatientsPathophysiologyBile formation and secretion: An update
Boyer JL, Soroka CJ. Bile formation and secretion: An update. Journal Of Hepatology 2021, 75: 190-201. PMID: 33617926, DOI: 10.1016/j.jhep.2021.02.011.Peer-Reviewed Original Research
2015
The origins of hepatobiliary and gastrointestinal physiology
Boyer JL. The origins of hepatobiliary and gastrointestinal physiology. Hepatology 2015, 61: 1452-1454. PMID: 25677183, PMCID: PMC4447183, DOI: 10.1002/hep.27737.Peer-Reviewed Original Research
2013
Biosynthesis and trafficking of the bile salt export pump, BSEP: Therapeutic implications of BSEP mutations
Soroka CJ, Boyer JL. Biosynthesis and trafficking of the bile salt export pump, BSEP: Therapeutic implications of BSEP mutations. Molecular Aspects Of Medicine 2013, 37: 3-14. PMID: 23685087, PMCID: PMC3784619, DOI: 10.1016/j.mam.2013.05.001.Peer-Reviewed Original ResearchConceptsBenign recurrent intrahepatic cholestasis type 2Progressive familial intrahepatic cholestasis type 2Cell biological aspectsBile salt export pumpTranslational regulationCell biologyMembrane transportersPrimary transporterBile salt-dependent bile flowType 2Bile acidsRate-limiting stepExport pumpDrug-induced cholestasisBiological aspectsBiosynthesisTraffickingTransportersBSEP mutationsMutationsCholestatic diseaseIntrahepatic cholestasisBile flowBiliary systemEnterohepatic circulation
1978
Stimulation of thymidine incorporation in mouse liver and biliary tract epithelium by lithocholate and deoxycholate
Bagheri S, Bolt M, Boyer J, Palmer R. Stimulation of thymidine incorporation in mouse liver and biliary tract epithelium by lithocholate and deoxycholate. Gastroenterology 1978, 74: 188-192. PMID: 620891, DOI: 10.1016/0016-5085(78)90793-x.Peer-Reviewed Original ResearchConceptsCertain bile acidsBiliary tractBile acidsBiliary tract epitheliumSingle oral dosesBile duct hyperplasiaBile acid poolBile saltsDuctular cell hyperplasiaPeliosis hepatisOral dosesHepatocellular necrosisBile ductCell hyperplasiaDuct hyperplasiaEnterohepatic circulationHepatic nodulesProliferative activityThymidine incorporationLiverEarly effectsLithocholateMouse liverDosesCell kinetics