2001
Cl−-dependent secretory mechanisms in isolated rat bile duct epithelial units
Singh S, Mennone A, Gigliozzi A, Fraioli F, Boyer J. Cl−-dependent secretory mechanisms in isolated rat bile duct epithelial units. AJP Gastrointestinal And Liver Physiology 2001, 281: g438-g446. PMID: 11447024, DOI: 10.1152/ajpgi.2001.281.2.g438.Peer-Reviewed Original ResearchMeSH KeywordsAmmonium ChlorideAnimalsBariumBicarbonatesBile Ducts, IntrahepaticBumetanideCarbon DioxideCarrier ProteinsCell PolarityCells, CulturedChloridesColforsinEpithelial CellsHydrogen-Ion ConcentrationIon TransportMaleModels, BiologicalRatsRats, Sprague-DawleySodiumSodium-Potassium-Chloride SymportersConceptsCO2/HCOFluid secretionCotransport activityIntrahepatic bile duct epitheliumBile duct epitheliumDependent fluid secretionHigh intracellular Cl(-) concentrationIntracellular Cl- concentrationBile duct unitsApical Cl(-) secretionNH entryInitial acidification rateIntracellular cAMP concentrationNH4Cl exposureDuct epitheliumInhibitor bumetanideChannel inhibitorsCl(-) secretionCanalicular bileDuct unitsSecretionDependent secretionSecretory mechanismBumetanideForskolin
1998
Intracellular pH regulation in bombesin-stimulated secretion in isolated bile duct units from rat liver
Cho W, Mennone A, Boyer J. Intracellular pH regulation in bombesin-stimulated secretion in isolated bile duct units from rat liver. American Journal Of Physiology 1998, 275: g1028-g1036. PMID: 9815033, DOI: 10.1152/ajpgi.1998.275.5.g1028.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntiportersBicarbonatesBile Ducts, IntrahepaticBombesinCarrier ProteinsChloride-Bicarbonate AntiportersChloridesFluoresceinsFluorescent DyesHEPESHydrogen-Ion ConcentrationIn Vitro TechniquesMaleModels, BiologicalRatsRats, Sprague-DawleySodiumSodium-Bicarbonate SymportersSodium-Hydrogen ExchangersConceptsHCO-3 secretionBile duct unitsDuct unitsAcid-extruding mechanismsEffect of bombesinRat liverCl-/HCOBombesin-stimulated secretionRegulation of intracellularBiliary secretionNormal rat liverBombesinCholangiocytesSecretionUnderlying mechanismLiverBasalPH regulationCounterregulatoryNeuropeptidesExchange activityActivity
1996
Disruption of Cell Volume Regulation by Mercuric Chloride Is Mediated by an Increase in Sodium Permeability and Inhibition of an Osmolyte Channel in Skate Hepatocytes
Ballatori N, Boyer J. Disruption of Cell Volume Regulation by Mercuric Chloride Is Mediated by an Increase in Sodium Permeability and Inhibition of an Osmolyte Channel in Skate Hepatocytes. Toxicology And Applied Pharmacology 1996, 140: 404-410. PMID: 8887458, DOI: 10.1006/taap.1996.0237.Peer-Reviewed Original Research
1995
Expression of sodium-independent organic anion uptake systems of skate liver in Xenopus laevis oocytes
Jacquemin E, Hagenbuch B, Wolkoff A, Meier P, Boyer J. Expression of sodium-independent organic anion uptake systems of skate liver in Xenopus laevis oocytes. American Journal Of Physiology 1995, 268: g18-g23. PMID: 7840202, DOI: 10.1152/ajpgi.1995.268.1.g18.Peer-Reviewed Original ResearchConceptsBSP uptakeSkate liverTaurocholate uptakeXenopus laevis oocytesOrganic anion transport systemInjection of oocytesLaevis oocytesLiverAnion transport systemRat liverSulfobromophthalein uptakeUptake systemOocytesMRNADisulfonic acidUptake activityFunctional expressionLiver mRNAUptakeExpressionSerum albuminLower vertebrates
1991
Mechanism of mercurial inhibition of sodium-coupled alanine uptake in liver plasma membrane vesicles from Raja erinacea
Sellinger M, Ballatori N, Boyer J. Mechanism of mercurial inhibition of sodium-coupled alanine uptake in liver plasma membrane vesicles from Raja erinacea. Toxicology And Applied Pharmacology 1991, 107: 369-376. PMID: 1994517, DOI: 10.1016/0041-008x(91)90216-2.Peer-Reviewed Original ResearchConceptsDependent alanine uptakePlasma membrane vesiclesMembrane vesiclesAlanine uptakePrimitive vertebratesPlasma membraneTransport proteinsConcentration-dependent mechanismLiver plasma membrane vesiclesMicroM HgCl2Mammalian hepatocytesAlanine carrierSulfhydryl groupsLittle skateMembrane integrityRaja erinaceaDirect interactionVesiclesVesicle integrityMembrane permeabilityMercurial inhibitionUptake rateDose-dependent mannerHgCl2 concentrationsLiver plasma membranes
1990
Modulation of Na+/alanine cotransport in liver sinusoidal membrane vesicles by internal divalent cations
Simmons T, Moseley R, Boyer J, Ballatori N. Modulation of Na+/alanine cotransport in liver sinusoidal membrane vesicles by internal divalent cations. Biochimica Et Biophysica Acta 1990, 1023: 462-468. PMID: 2110482, DOI: 10.1016/0005-2736(90)90140-j.Peer-Reviewed Original ResearchEffects of osmotic stresses on isolated rat hepatocytes. II. Modulation of intracellular pH
Gleeson D, Corasanti J, Boyer J. Effects of osmotic stresses on isolated rat hepatocytes. II. Modulation of intracellular pH. American Journal Of Physiology 1990, 258: g299-g307. PMID: 2305896, DOI: 10.1152/ajpgi.1990.258.2.g299.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic AcidAnimalsBicarbonatesBuffersCells, CulturedCholineHydrogen-Ion ConcentrationHypertonic SolutionsHypotonic SolutionsIntracellular FluidKineticsLiverMaleOsmolar ConcentrationRatsRats, Inbred StrainsSodiumConceptsRegulatory volume decreaseAbsence of HCO3Presence of HCO3Acid-base transport systemsModulation of intracellularRat hepatocytesVolume regulationAcute withdrawalMM amilorideGreater intracellularHCO3- exchangeAcid effluxIsotonic mediumIsolated rat hepatocytesSame maneuverCell volume regulationHepatocytesNet acid effluxAmilorideSubconfluent monolayersDisulfonic acidIntracellularVolume decreaseHypotonic mediumHypertonic medium
1988
Effect of l-alanine on membrane potential, potassium (86Rb) permeability and cell volume in hepatocytes from Raja erinacea
Ballatori N, Wondergem R, Boyer J. Effect of l-alanine on membrane potential, potassium (86Rb) permeability and cell volume in hepatocytes from Raja erinacea. Biochimica Et Biophysica Acta 1988, 946: 261-269. PMID: 3207743, DOI: 10.1016/0005-2736(88)90401-4.Peer-Reviewed Original Research
1987
Cell membrane and transepithelial voltages and resistances in isolated rat hepatocyte couplets
Graf J, Henderson R, Krumpholz B, Boyer J. Cell membrane and transepithelial voltages and resistances in isolated rat hepatocyte couplets. The Journal Of Membrane Biology 1987, 95: 241-254. PMID: 3585979, DOI: 10.1007/bf01869486.Peer-Reviewed Original ResearchUrsodeoxycholate stimulates Na+-H+ exchange in rat liver basolateral plasma membrane vesicles.
Moseley R, Ballatori N, Smith D, Boyer J. Ursodeoxycholate stimulates Na+-H+ exchange in rat liver basolateral plasma membrane vesicles. Journal Of Clinical Investigation 1987, 80: 684-690. PMID: 3040805, PMCID: PMC442291, DOI: 10.1172/jci113122.Peer-Reviewed Original ResearchTaurocholate uptake by isolated skate hepatocytes: effect of albumin
Smith D, Grossbard M, Gordon E, Boyer J. Taurocholate uptake by isolated skate hepatocytes: effect of albumin. American Journal Of Physiology 1987, 252: g479-g484. PMID: 3565567, DOI: 10.1152/ajpgi.1987.252.4.g479.Peer-Reviewed Original Research
1986
Sodium gradient-dependent L-glutamate transport is localized to the canalicular domain of liver plasma membranes. Studies in rat liver sinusoidal and canalicular membrane vesicles.
Ballatori N, Moseley R, Boyer J. Sodium gradient-dependent L-glutamate transport is localized to the canalicular domain of liver plasma membranes. Studies in rat liver sinusoidal and canalicular membrane vesicles. Journal Of Biological Chemistry 1986, 261: 6216-6221. PMID: 2871024, DOI: 10.1016/s0021-9258(19)84550-7.Peer-Reviewed Original Research
1985
Evidence for carrier-mediated chloride/bicarbonate exchange in canalicular rat liver plasma membrane vesicles.
Meier P, Knickelbein R, Moseley R, Dobbins J, Boyer J. Evidence for carrier-mediated chloride/bicarbonate exchange in canalicular rat liver plasma membrane vesicles. Journal Of Clinical Investigation 1985, 75: 1256-1263. PMID: 2985654, PMCID: PMC425453, DOI: 10.1172/jci111824.Peer-Reviewed Original ResearchMechanisms of Electrolyte Transport in the Liver Their Functional Significance
Moseley R, Boyer J. Mechanisms of Electrolyte Transport in the Liver Their Functional Significance. Seminars In Liver Disease 1985, 5: 122-135. PMID: 3161181, DOI: 10.1055/s-2008-1063917.Peer-Reviewed Original Research
1983
Direct determination of the driving forces for taurocholate uptake into rat liver plasma membrane vesicles.
Duffy M, Blitzer B, Boyer J. Direct determination of the driving forces for taurocholate uptake into rat liver plasma membrane vesicles. Journal Of Clinical Investigation 1983, 72: 1470-1481. PMID: 6630516, PMCID: PMC370431, DOI: 10.1172/jci111103.Peer-Reviewed Original Research
1982
Effects of inhibitors of Na+-coupled ion transport on bile acid uptake by isolated rat hepatocytes
Blitzer B, Ratoosh S, Donovan C, Boyer J. Effects of inhibitors of Na+-coupled ion transport on bile acid uptake by isolated rat hepatocytes. American Journal Of Physiology 1982, 243: g48-g53. PMID: 6283917, DOI: 10.1152/ajpgi.1982.243.1.g48.Peer-Reviewed Original Research
1970
The effect of sodium taurocholate on the hepatic metabolism of sulfobromophthalein sodium (BSP). The role of bile flow
Boyer J, Scheig R, Klatskin G. The effect of sodium taurocholate on the hepatic metabolism of sulfobromophthalein sodium (BSP). The role of bile flow. Journal Of Clinical Investigation 1970, 49: 206-215. PMID: 5411780, PMCID: PMC322462, DOI: 10.1172/jci106229.Peer-Reviewed Original ResearchConceptsBile salt excretionBSP TmBile flowBile productionBiliary concentrationHepatic metabolismBile saltsBiliary bile salt excretionSalt excretionSulfobromophthalein sodiumSodium taurocholateMug/minSodium taurocholate infusionBile salt infusionBSP transportCholeretic propertiesSaline infusionTaurocholate infusionIndependent factorsConstant infusionHepatic uptakeMumoles/hrInfusionMul/minPeak levels