1977
Taurolithocholate-Induced Cholestasis: Taurocholate, but not Dehydrocholate, Reverses Cholestasis and Bile Canalicular Membrane Injury
Layden T, Boyer J. Taurolithocholate-Induced Cholestasis: Taurocholate, but not Dehydrocholate, Reverses Cholestasis and Bile Canalicular Membrane Injury. Gastroenterology 1977, 73: 120-128. PMID: 863183, DOI: 10.1016/s0016-5085(19)32283-8.Peer-Reviewed Original ResearchEvaluation of a New Monkey Model for the Repeated Study of Bile Secretory Physiology
WOOD R, BAKER A, HALL A, BOYER J, MOOSSA A. Evaluation of a New Monkey Model for the Repeated Study of Bile Secretory Physiology. Annals Of Surgery 1977, 185: 349-355. PMID: 402891, PMCID: PMC1396621, DOI: 10.1097/00000658-197703000-00017.Peer-Reviewed Original ResearchConceptsBile flowSecretory physiologyMonkey modelBile salt secretion rateFinal infusion rateBile salt excretionBile salt outputHigher bile flowNew monkey modelSalt secretion rateBicarbonate outputPostoperative managementInfusion rateTaurocholate infusionSalt outputSalt excretionSecretion rateLong-term studiesRandom orderPeriod of monthsSecretinClearance
1975
Scanning Electron Microscopy of the Rat Liver Studies of the effect of taurolithocholate and other models of cholestasis
Layden T, Schwarz J, Boyer J. Scanning Electron Microscopy of the Rat Liver Studies of the effect of taurolithocholate and other models of cholestasis. Gastroenterology 1975, 69: 724-738. PMID: 1158090, DOI: 10.1016/s0016-5085(19)32475-8.Peer-Reviewed Original ResearchConceptsModel of cholestasisBile duct ligationEstradiol treatmentDuct ligationEffect of cholestasisEffect of taurolithocholateTLC-induced cholestasisDirect toxic effectBile canaliculiLithocholate sulfateRat liver studiesCanalicular membraneLoss of microvilliNormal findingsFinger fracturesPortal veinDistinctive abnormalitiesSimultaneous infusionCholestasisSodium taurolithocholateSevere abnormalitiesSodium taurocholateInfusionTaurolithocholateLiver studies