1996
Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis
Gartung C, Ananthanarayanan M, Rahman M, Schuele S, Nundy S, Soroka C, Stolz A, Suchy F, Boyer J. Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis. Gastroenterology 1996, 110: 199-209. PMID: 8536857, DOI: 10.1053/gast.1996.v110.pm8536857.Peer-Reviewed Original ResearchMeSH Keywords3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)3-Hydroxysteroid DehydrogenasesAnimalsCarrier ProteinsCholestasis, ExtrahepaticCommon Bile DuctDown-RegulationHomeostasisLigationLiverMaleOrganic Anion Transporters, Sodium-DependentProteinsRatsRats, Sprague-DawleyRNA, MessengerSymportersTaurocholic AcidTissue DistributionTranscription, GeneticConceptsEcto-adenosine triphosphataseRegulation of expressionMolecular regulationPosttranscriptional regulationGene transcriptionSteady-state messenger RNA levelsTranscriptional activityAcid transportersProtective feedback mechanismComplementary DNAAcid cotransporterMessenger RNA levelsSodium-dependent taurocholateTranscriptionRNA levelsRegulationBile acid transporterMRNA levelsHepatic bile acid transportersCanalicular localizationTaurocholate uptakeAlpha-hydroxysteroid dehydrogenaseExpressionNtcp proteinTriphosphatase
1982
Effects of taurocholate on the size of mixed lipid micelles and their associations with pigment and proteins in rat bile
Reuben A, Howell K, Boyer J. Effects of taurocholate on the size of mixed lipid micelles and their associations with pigment and proteins in rat bile. Journal Of Lipid Research 1982, 23: 1039-1052. PMID: 7142812, DOI: 10.1016/s0022-2275(20)38077-9.Peer-Reviewed Original ResearchConceptsLipid micellesMixed micellesElution profilesHigh molecular weight protein aggregatesMicelle sizeMicellesMicellar radiusMixed lipid micellesBile pigmentsWeight protein aggregatesRat bileSalt peakUnconjugated dyeColumn fractionsTaurocholate concentrationPigmentsSephadex G200 chromatographyConstituents of bileColumnDyeProtein aggregatesEffect of taurocholateChromatographyConcentrationMM
1977
Effects of chronic choleretic infusions of bile acids on the membrane of the bile canaliculus. A biochemical and morphologic study.
Nemchausky B, Layden T, Boyer J. Effects of chronic choleretic infusions of bile acids on the membrane of the bile canaliculus. A biochemical and morphologic study. Laboratory Investigation 1977, 36: 259-67. PMID: 138767.Peer-Reviewed Original Research