2001
Bile salt export pump is highly conserved during vertebrate evolution and its expression is inhibited by PFIC type II mutations
Cai S, Wang L, Ballatori N, Boyer J. Bile salt export pump is highly conserved during vertebrate evolution and its expression is inhibited by PFIC type II mutations. AJP Gastrointestinal And Liver Physiology 2001, 281: g316-g322. PMID: 11447010, DOI: 10.1152/ajpgi.2001.281.2.g316.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsATP Binding Cassette Transporter, Subfamily B, Member 11ATP-Binding Cassette TransportersBiological TransportCholestasis, IntrahepaticCloning, MolecularConserved SequenceEvolution, MolecularHumansLiverMolecular Sequence DataMutationPhylogenyRNA, MessengerSequence Homology, Amino AcidSkates, FishSpodopteraTaurocholic AcidTransfectionConceptsSf9 cellsATP-dependent transport proteinsFull-length cloneATP-dependent export pumpLiver cDNA libraryNorthern blot analysisStructure-function relationshipsVertebrate evolutionEvolutionary originHuman BSEPBile salt export pump BSEPMutant proteinsSkate Raja erinaceaHigher vertebratesCDNA libraryTransport proteinsSixfold stimulationVertebratesType II mutationAmino acidsRaja erinaceaDefective expressionBlot analysisExport pumpMutations
2000
A Primitive ATP Receptor from the Little Skate Raja erinacea *
Dranoff J, O'Neill A, Franco A, Cai S, Connolly G, Ballatori N, Boyer J, Nathanson M. A Primitive ATP Receptor from the Little Skate Raja erinacea *. Journal Of Biological Chemistry 2000, 275: 30701-30706. PMID: 10900200, DOI: 10.1074/jbc.m003366200.Peer-Reviewed Original ResearchConceptsLittle skate Raja erinaceaSkate Raja erinaceaDegenerate oligonucleotide probeRaja erinaceaP2Y receptor pharmacologySingle polymerase chain reaction productXenopus oocyte expression systemLiver cDNA libraryATP receptorsHigher organismsEvolutionary forerunnerCommon ancestorOocyte expression systemPhylogenetic analysisP2Y receptorsCDNA clonesPrimitive organismsCDNA libraryGene productsSubstrate preferenceMolecular basisExpression systemNucleotide specificityMammalian tissuesRange of nucleotides
1999
Hepatic Toxicity and Persistence of ser/thr Protein Phosphatase Inhibition by Microcystin in the Little Skate Raja erinacea
Runnegar M, Seward D, Ballatori N, Crawford J, Boyer J. Hepatic Toxicity and Persistence of ser/thr Protein Phosphatase Inhibition by Microcystin in the Little Skate Raja erinacea. Toxicology And Applied Pharmacology 1999, 161: 40-49. PMID: 10558922, DOI: 10.1006/taap.1999.8783.Peer-Reviewed Original ResearchConceptsDose-dependent inhibitionSkate hepatocytesUptake of microcystinNear complete inhibitionPP activityInflammatory changesHepatic toxicityHepatocyte necrosisHistological changesAccompanying inhibitionHepatic lesionsBile acidsHigh dosesOnly organSignificant inhibitionSkate Raja erinaceaLittle skate Raja erinaceaInhibitionLiverRectal gland
1996
Swelling-activated anion conductance in skate hepatocytes: regulation by cell Cl- and ATP
Jackson P, Churchwell K, Ballatori N, Boyer J, Strange K. Swelling-activated anion conductance in skate hepatocytes: regulation by cell Cl- and ATP. American Journal Of Physiology 1996, 270: c57-c66. PMID: 8772430, DOI: 10.1152/ajpcell.1996.270.1.c57.Peer-Reviewed Original Research