Validation of 13CO2 breath analysis as a measurement of demethylation of stable isotope labeled aminopyrine in man
Schneider J, Schoeller D, Nemchausky B, Boyer J, Klein P. Validation of 13CO2 breath analysis as a measurement of demethylation of stable isotope labeled aminopyrine in man. Clinica Chimica Acta 1978, 84: 153-162. PMID: 639299, DOI: 10.1016/0009-8981(78)90489-8.Peer-Reviewed Original ResearchConceptsLiver diseaseHepatic microsomal drug metabolismMicrosomal drug metabolismSimultaneous oral administrationDrug-drug interactionsNon-invasive assessmentN-demethylation activityOral doseCumulative excretionOral administrationEffects of diseaseExcretion of labelAdult subjectsDrug metabolismDiseaseExpired breathCumulative appearanceHuman subjectsPatientsReproducible increaseAminopyrineRadiation riskExcretionSubjectsHours