1996
Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes
Beuers U, Throckmorton D, Anderson, Isales C, Thasler W, Kullak-Ublick G, Sauter G, Koebe H, Paumgartner G, Boyer J. Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes. Gastroenterology 1996, 110: 1553-1563. PMID: 8613063, DOI: 10.1053/gast.1996.v110.pm8613063.Peer-Reviewed Original ResearchConceptsEffect of TUDCATauroursodeoxycholic acidProtein kinase CHepatocellular Ca2Chronic cholestatic liver diseaseCholestatic liver diseaseAlpha-PKCPKC activityLiver diseaseLiver functionRadioenzymatic techniqueExperimental cholestasisPhorbol ester phorbolActivation of PKCKinase CTaurocholic acidImmunofluorescence techniqueAbstractTextMembrane-associated PKC activitySignificant increaseAIMSStimulation of exocytosisUnknown mechanismParticulate membrane fractionHepatocytes
1980
Aminopyrine n-Demethylation: A Prognostic test of liver function in patients with alcoholic liver disease
Schneider J, Baker A, Haines N, Hatfield G, Boyer J. Aminopyrine n-Demethylation: A Prognostic test of liver function in patients with alcoholic liver disease. Gastroenterology 1980, 79: 1145-1150. PMID: 6777231, DOI: 10.1016/0016-5085(80)90906-3.Peer-Reviewed Original ResearchConceptsAminopyrine breath testAlcoholic liver diseaseBreath testLiver diseaseAlcoholic hepatitisClinical improvementHistologic severityLiver functionConventional liver function testsLiver function testsGroup of patientsShort-term survivalClinical featuresFunction testsHistologic confirmationClinical statusProthrombin timePatientsPrognostic testDiseaseHepatitisSeveritySurvivalSGPTSGOT