1999
Hepatic Toxicity and Persistence of ser/thr Protein Phosphatase Inhibition by Microcystin in the Little Skate Raja erinacea
Runnegar M, Seward D, Ballatori N, Crawford J, Boyer J. Hepatic Toxicity and Persistence of ser/thr Protein Phosphatase Inhibition by Microcystin in the Little Skate Raja erinacea. Toxicology And Applied Pharmacology 1999, 161: 40-49. PMID: 10558922, DOI: 10.1006/taap.1999.8783.Peer-Reviewed Original ResearchConceptsDose-dependent inhibitionSkate hepatocytesUptake of microcystinNear complete inhibitionPP activityInflammatory changesHepatic toxicityHepatocyte necrosisHistological changesAccompanying inhibitionHepatic lesionsBile acidsHigh dosesOnly organSignificant inhibitionSkate Raja erinaceaLittle skate Raja erinaceaInhibitionLiverRectal gland
1994
Characteristics of bile salt uptake into skate hepatocytes
Fricker G, Dubost V, Finsterwald K, Boyer J. Characteristics of bile salt uptake into skate hepatocytes. Biochemical Journal 1994, 299: 665-670. PMID: 8192655, PMCID: PMC1138072, DOI: 10.1042/bj2990665.Peer-Reviewed Original ResearchConceptsOrganic anion transport systemBile salt uptakeBile alcoholsBile saltsBeta-cholestane-3 alphaBile salt transportUnconjugated bile saltsTaurine-conjugated bile saltsHepatic uptakeAlpha-triolSkate bileInhibitory effectLiver cellsSkate hepatocytesIndependent transport systemsCholyltaurine transportCholyltaurineHepatocytesInhibitionAlphaUptakeSpecificity
1970
Inhibition of Postheparin Lipolytic Activity in Uremia and its Relationship to Hypertriglyceridemia 1
Boyer J, Scheig R. Inhibition of Postheparin Lipolytic Activity in Uremia and its Relationship to Hypertriglyceridemia 1. Experimental Biology And Medicine 1970, 134: 603-605. PMID: 5431345, DOI: 10.3181/00379727-134-34842.Peer-Reviewed Original ResearchConceptsPostheparin lipolytic activityUremic patientsTriglyceride levelsPathogenesis of hypertriglyceridemiaTwice-weekly hemodialysisSerum triglyceride levelsLipoprotein electrophoretic patternsPlasma triglyceride levelsDegree of impairmentRenal failureChronic uremiaLipolytic activityPlasma clearanceNormal subjectsRat chylomicronsPatientsDegree of inhibitionPlasma inhibitorUremiaInhibitionHypertriglyceridemiaHemodialysisHyperlipemiaElectrophoretic patternsPathogenesis