1999
Hepatic Toxicity and Persistence of ser/thr Protein Phosphatase Inhibition by Microcystin in the Little Skate Raja erinacea
Runnegar M, Seward D, Ballatori N, Crawford J, Boyer J. Hepatic Toxicity and Persistence of ser/thr Protein Phosphatase Inhibition by Microcystin in the Little Skate Raja erinacea. Toxicology And Applied Pharmacology 1999, 161: 40-49. PMID: 10558922, DOI: 10.1006/taap.1999.8783.Peer-Reviewed Original ResearchConceptsDose-dependent inhibitionSkate hepatocytesUptake of microcystinNear complete inhibitionPP activityInflammatory changesHepatic toxicityHepatocyte necrosisHistological changesAccompanying inhibitionHepatic lesionsBile acidsHigh dosesOnly organSignificant inhibitionSkate Raja erinaceaLittle skate Raja erinaceaInhibitionLiverRectal gland
1978
Metabolism affects the hepatic toxicity of chlorprohazine (CPZ) in the isolated perfused rat liver (IPRL)
Tavoloni N, Nemchausky B, Reed J, Boyer J. Metabolism affects the hepatic toxicity of chlorprohazine (CPZ) in the isolated perfused rat liver (IPRL). Gastroenterology 1978, 75: 990. DOI: 10.1016/0016-5085(78)90661-3.Peer-Reviewed Original ResearchHepatic toxicityRat liver