A C‐terminal tyrosine‐based motif in the bile salt export pump directs clathrin‐dependent endocytosis
Lam P, Xu S, Soroka CJ, Boyer JL. A C‐terminal tyrosine‐based motif in the bile salt export pump directs clathrin‐dependent endocytosis. Hepatology 2012, 55: 1901-1911. PMID: 22161577, PMCID: PMC3319652, DOI: 10.1002/hep.25523.Peer-Reviewed Original ResearchConceptsTyrosine-based motifNucleotide-binding domainEndocytic motifTransmembrane segmentsCanonical tyrosine-based motifTyrosine-based endocytic motifCytoplasmic nucleotide-binding domainsClathrin-dependent pathwayClathrin-dependent endocytosisRegulation of traffickingBroad substrate specificitySite-directed mutagenesisATP-dependent transportHEK293T cellsCytoplasmic terminiEndocytosis motifCassette proteinSubsequent sequence analysisTerminal tailSubstrate specificityConstitutive internalizationReporter systemSequence analysisBile salt export pumpTerminal end