2021
The role of bile acids in cholestatic liver injury
Cai SY, Boyer JL. The role of bile acids in cholestatic liver injury. Annals Of Translational Medicine 2021, 9: 737-737. PMID: 33987435, PMCID: PMC8106037, DOI: 10.21037/atm-20-5110.Peer-Reviewed Original ResearchCholestatic liver injuryBile duct proliferationLiver injuryParenchymal cell deathBile acidsDuct proliferationImmune cellsStellate cellsProliferation of cholangiocytesSphingosine-1-phosphate receptor 2Bile acid receptorCell deathMajor cellular componentLiver inflammationClinical evidenceInflammatory cytokinesLiver fibrosisPathogenic rolePathologic effectsReceptor 2Mitochondrial injuryAcid receptorsClinical disordersInjuryOxidative stress
2000
Induction of murine hepatocyte death by membrane‐bound CD95 (Fas/APO‐1)‐ligand: Characterization of an in Vitro system
Schlosser S, Azzaroli F, Dao T, Hingorani R, Crispe I, Boyer J. Induction of murine hepatocyte death by membrane‐bound CD95 (Fas/APO‐1)‐ligand: Characterization of an in Vitro system. Hepatology 2000, 32: 779-785. PMID: 11003622, DOI: 10.1053/jhep.2000.18422.Peer-Reviewed Original ResearchConceptsMouse hepatocytesMembrane-bound CD95LNIH 3T3 fibroblastsFas/APOProtein synthesis inhibitorPrimary mouse hepatocytesDNA strand breaksCultured mouse hepatocytesNuclear condensationAnti-CD95 antibodiesCell deathNuclear fragmentationBiochemical studiesStrand breaksCD95 ligandVitro systemCell apoptosisExposure of hepatocytesApoptosisCD95Potential targetCD95LSynthesis inhibitorCytoplasmic blebsLiver cell apoptosis
1998
Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo
Zheng T, Schlosser S, Dao T, Hingorani R, Crispe I, Boyer J, Flavell R. Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 13618-13623. PMID: 9811849, PMCID: PMC24868, DOI: 10.1073/pnas.95.23.13618.Peer-Reviewed Original ResearchConceptsCell deathDNA fragmentationFas-induced cell deathCaspase-3-like activityTypical apoptotic featuresCaspase-3NIH 3T3 cellsDFF45/ICADCaspase substratesApoptotic caspasesCaspase-1Apoptotic eventsApoptotic featuresCaspasesMorphological changesAberrant apoptosisNuclear eventsKey substrateNuclear fragmentationHepatocyte cell deathCytoplasmic blebbingApoptosisDifferent morphological changesAltered cleavageFA