Induction of murine hepatocyte death by membrane‐bound CD95 (Fas/APO‐1)‐ligand: Characterization of an in Vitro system
Schlosser S, Azzaroli F, Dao T, Hingorani R, Crispe I, Boyer J. Induction of murine hepatocyte death by membrane‐bound CD95 (Fas/APO‐1)‐ligand: Characterization of an in Vitro system. Hepatology 2000, 32: 779-785. PMID: 11003622, DOI: 10.1053/jhep.2000.18422.Peer-Reviewed Original ResearchConceptsMouse hepatocytesMembrane-bound CD95LNIH 3T3 fibroblastsFas/APOProtein synthesis inhibitorPrimary mouse hepatocytesDNA strand breaksCultured mouse hepatocytesNuclear condensationAnti-CD95 antibodiesCell deathNuclear fragmentationBiochemical studiesStrand breaksCD95 ligandVitro systemCell apoptosisExposure of hepatocytesApoptosisCD95Potential targetCD95LSynthesis inhibitorCytoplasmic blebsLiver cell apoptosis