2001
Cholestatic syndromes
Trauner M, Boyer J. Cholestatic syndromes. Current Opinion In Gastroenterology 2001, 17: 242-256. PMID: 17031165, DOI: 10.1097/00001574-200105000-00007.Peer-Reviewed Original ResearchCholestatic syndromeTotal parenteral nutrition-induced cholestasisParenteral nutrition-induced cholestasisHereditary cholestatic syndromesPrimary biliary cirrhosisCholestasis of pregnancyCholestatic liver diseaseDrug-induced cholestasisHepatobiliary transport proteinsBiliary cirrhosisClinical featuresLiver diseaseBile secretionCholestasisSyndromePathogenesisImportant new studiesNew studiesCholangitisCirrhosisPregnancyDiseaseSecretionTransporter gene
2000
Cholestatic syndromes
Trauner M, Boyer J. Cholestatic syndromes. Current Opinion In Gastroenterology 2000, 16: 239-250. PMID: 17023881, DOI: 10.1097/00001574-200005000-00006.Peer-Reviewed Original Research
1999
Vasoactive intestinal polypeptide is a potent regulator of bile secretion from rat cholangiocytes
Cho W, Boyer J. Vasoactive intestinal polypeptide is a potent regulator of bile secretion from rat cholangiocytes. Gastroenterology 1999, 117: 420-428. PMID: 10419925, DOI: 10.1053/gast.1999.0029900420.Peer-Reviewed Original ResearchConceptsBile duct unitsEffect of VIPBile flowBile secretionDuct unitsIntestinal polypeptideFluid secretionBile duct-ligated ratsBile salt outputVasoactive intestinal polypeptideHepatocyte coupletsDose-dependent increaseDuct-ligated ratsBile pHVIP antagonistSite of actionSubstance PSecretory responseVIP responsesReceptor inhibitorsCAMP-independent pathwayBicarbonate secretionPotent stimulantSalt outputAbstractText
1998
Nitric oxide and guanosine 3′,5′‐cyclic monophosphate stimulate bile secretion in isolated rat hepatocyte couplets, but not in isolated bile duct units
Trauner M, Mennone A, Gigliozzi A, Fraioli F, Boyer J. Nitric oxide and guanosine 3′,5′‐cyclic monophosphate stimulate bile secretion in isolated rat hepatocyte couplets, but not in isolated bile duct units. Hepatology 1998, 28: 1621-1628. PMID: 9828227, DOI: 10.1002/hep.510280623.Peer-Reviewed Original ResearchConceptsDuctular bile secretionBile secretionBile duct unitsNitric oxideRat hepatocyte coupletsExchanger activityNO synthesisCl-/HCO3Bile acid-independent bile flowCell-permeant cGMP analogDuct unitsEndogenous NO synthesisHepatocyte coupletsEffect of NOCell-permeant cAMP analogsLevel of hepatocytesCyclic monophosphateHepatic NO synthesisRemoval of HCO3Canalicular bile secretionNG-monomethylBile flowCholeretic effectDuctular luminaL-arginine
1997
Bombesin stimulates bicarbonate secretion from rat cholangiocytes: Implications for neural regulation of bile secretion
Cho W, Mennone A, Rydberg, Boyer J. Bombesin stimulates bicarbonate secretion from rat cholangiocytes: Implications for neural regulation of bile secretion. Gastroenterology 1997, 113: 311-321. PMID: 9207292, DOI: 10.1016/s0016-5085(97)70109-4.Peer-Reviewed Original ResearchConceptsBile secretionBicarbonate secretionRat liverBile duct-ligated ratsRole of bombesinHepatocyte coupletsEffect of bombesinDose-dependent increaseDuct-ligated ratsBile duct unitsCanalicular bile secretionBile pHSite of actionBile flowSubstance PReceptor inhibitorsNeural regulationAbstractTextBombesinBiliary transportDuct unitsSecretionLiverLuminal pHRat cholangiocytes
1996
Bile secretion-models, mechanisms, and malfunctions. A perspective on the development of modern cellular and molecular concepts of bile secretion and cholestasis
Boyer J. Bile secretion-models, mechanisms, and malfunctions. A perspective on the development of modern cellular and molecular concepts of bile secretion and cholestasis. Journal Of Gastroenterology 1996, 31: 475-481. PMID: 8726846, DOI: 10.1007/bf02355044.Peer-Reviewed Original ResearchConceptsBile secretion
1992
Effects of Ca2+ agonists on cytosolic Ca2+ in isolated hepatocytes and on bile secretion in the isolated perfused rat liver
Nathanson M, Gautam A, Bruck R, Isales C, Boyer J. Effects of Ca2+ agonists on cytosolic Ca2+ in isolated hepatocytes and on bile secretion in the isolated perfused rat liver. Hepatology 1992, 15: 107-116. PMID: 1727785, DOI: 10.1002/hep.1840150119.Peer-Reviewed Original ResearchConceptsBile flowPerfusion pressureBile secretionCytosolic Ca2Rat liverProtein kinase CIonophore-induced increaseBromo-A23187Hepatic vasoconstrictionVasodilator papaverineProtein kinase C inhibitor HExtracellular Ca2Kinase CSecretionLiverVasopressinAgonist vasopressinBenzohydroquinoneEffect of Ca2HepatocytesActivate protein kinase CInhibitor HTwo-thirdsIsolated hepatocytesSensitive photoprotein aequorin
1989
Protein kinase C agonists inhibit bile secretion independently of effects on the microcirculation in the isolated perfused rat liver
Corasanti J, Smith N, Gordon E, Boyer J. Protein kinase C agonists inhibit bile secretion independently of effects on the microcirculation in the isolated perfused rat liver. Hepatology 1989, 10: 8-13. PMID: 2737605, DOI: 10.1002/hep.1840100103.Peer-Reviewed Original ResearchConceptsBile flowPerfusion pressureBile secretionVehicle dimethyl sulfoxideReversible decreaseConstant perfusate flowPhorbol dibutyrateVenous effluent concentrationsInactive phorbol ester 4Rat liver systemVascular redistributionHepatic microvasculaturePhorbol esterPhorbol ester 4Vasoactive agentsRole of hormonesPerfusate flowTrypan blue dyeAntagonist HProtein kinase C agonistsGm liverActive phorbol estersLiver systemRat liverOxygen consumptionVoltage-driven, taurocholate-dependent secretion in isolated hepatocyte couplets
Weinman S, Graf J, Boyer J. Voltage-driven, taurocholate-dependent secretion in isolated hepatocyte couplets. American Journal Of Physiology 1989, 256: g826-g832. PMID: 2719107, DOI: 10.1152/ajpgi.1989.256.5.g826.Peer-Reviewed Original ResearchConceptsBile secretionBile acidsSecretion rateFluid secretionIntracellular current injectionCanalicular areaHepatocyte coupletsMembrane potentialRat hepatocyte coupletsAbsence of taurocholateMicroM taurocholateFluid secretion rateBile formationSecretionCarrier-mediated transportTaurocholateLiverIntracellular voltage
1987
Mechanisms of Bile Secretion and Hepatic Transport
Boyer J. Mechanisms of Bile Secretion and Hepatic Transport. 1987, 225-252. DOI: 10.1007/978-1-4684-5404-8_12.Peer-Reviewed Original Research
1986
Mechanisms of Bile Secretion and Hepatic Transport
Boyer J. Mechanisms of Bile Secretion and Hepatic Transport. 1986, 609-636. DOI: 10.1007/978-1-4613-2097-5_35.Peer-Reviewed Original Research
1982
Hemodynamic effects on oxygen consumption and bile flow in isolated skate liver
Reed J, Smith N, Boyer J. Hemodynamic effects on oxygen consumption and bile flow in isolated skate liver. American Journal Of Physiology 1982, 242: g313-g318. PMID: 7065253, DOI: 10.1152/ajpgi.1982.242.4.g313.Peer-Reviewed Original ResearchConceptsPerfusion pressureBile flowSkate liverOxygen consumptionOrganic anion clearanceBile flow ratePortal vein pressurePerfusion of liversHemodynamic effectsVein pressureBile secretionFractional disappearance rateHepatic clearanceLiverDisappearance rateRinger's solutionPerfusionBileClearanceTaurocholateRaja erinaceaSulfobromophthaleinVivoMammalian speciesPerfusate
1979
Effect of chlorpromazine on hepatic perfusion and bile secretory function in the isolated perfused rat liver.
Tavoloni N, Reed J, Hruban Z, Boyer J. Effect of chlorpromazine on hepatic perfusion and bile secretory function in the isolated perfused rat liver. Translational Research 1979, 94: 726-41. PMID: 227976.Peer-Reviewed Original ResearchConceptsHepatic perfusionPerfusate flowBile secretionBile acid-independent bile secretionSecretory functionBile acid excretionBile secretory functionRat liverEffect of chlorpromazineLiver 20 minLobar distributionHepatic lobeAcid excretionBaseline valuesPerfusate concentrationConstant infusionHepatic ultrastructureBile acidsControl valuesCPZSodium taurocholateLiverPerfusionGM-1Liver plasma membranes