Clinically significant cardiac disease in patients with Hodgkin lymphoma treated with mediastinal irradiation
Galper S, Yu J, Mauch P, Strasser J, Silver B, LaCasce A, Marcus K, Stevenson M, Chen M, Ng A. Clinically significant cardiac disease in patients with Hodgkin lymphoma treated with mediastinal irradiation. Blood 2010, 117: 412-418. PMID: 20858859, DOI: 10.1182/blood-2010-06-291328.Peer-Reviewed Original ResearchConceptsStandardized incidence ratioClinically significant cardiac diseaseSignificant cardiac diseaseMediastinal irradiationAbsolute excess riskCardiac eventsCardiac proceduresIncidence rate of cardiac eventsCardiac diseaseRate of cardiac eventsExcess riskSurvivors of Hodgkin lymphomaCoronary artery bypass graftingMedian follow-upCox regression analysisArtery bypass graftingCumulative incidence rateAssociated with excess riskImplantable cardioverter defibrillatorHodgkin lymphomaRadiation therapyValve surgeryCardiac surveillanceCardiac complicationsPacemaker placement