Cross Talk Between Estradiol and mTOR Kinase in the Regulation of Ovarian Granulosa Proliferation
Yu J, Thomson T, Johnson J. Cross Talk Between Estradiol and mTOR Kinase in the Regulation of Ovarian Granulosa Proliferation. Reproductive Sciences 2012, 19: 143-151. PMID: 22383759, DOI: 10.1177/1933719111424447.Peer-Reviewed Original ResearchConceptsMammalian target of rapamycinGranulosa cellsFollicle growthAccelerated follicle growthReverse transcriptase polymerase chain reactionTranscriptase polymerase chain reactionOvarian granulosa cellsPresence of estradiolGene array analysisQuantitative reverse transcriptase polymerase chain reactionGrowth of ovarian folliclesPhosphorylation of mammalian target of rapamycinInhibin-alphaIntegrin beta 1Calcineurin expressionTarget of rapamycinPolymerase chain reactionMTOR inhibitorsEverolimusTemsirolimusBiphasic effectDrug treatmentOvarian folliclesReduced proliferationDose curves