2024
Long-Term Patient-Reported Health-Related Quality of Life in the Randomized FORMULA-509 Trial of Salvage Radiotherapy and 6 Months of GnRH Agonist with Either Bicalutamide or Abiraterone Acetate Plus Prednisone and Apalutamide after Radical Prostatectomy
Hoffman K, Nguyen P, Rathkopf D, Zurita-Saavedra A, Spratt D, Dess R, Liauw S, Szmulewitz R, Einstein D, Bubley G, Yu J, An Y, Wong A, Feng F, Mckay R, Rose B, Lee K, Kibel A, Taplin M, Kollmeier M. Long-Term Patient-Reported Health-Related Quality of Life in the Randomized FORMULA-509 Trial of Salvage Radiotherapy and 6 Months of GnRH Agonist with Either Bicalutamide or Abiraterone Acetate Plus Prednisone and Apalutamide after Radical Prostatectomy. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: s54. DOI: 10.1016/j.ijrobp.2024.07.088.Peer-Reviewed Original ResearchAbiraterone acetate plus prednisoneMonths of GnRH agonistAcetate plus prednisonePatient-reported health-related quality of lifeEPIC-26Hormonal functionHealth-related quality of lifeGnRH agonistTreatment armsTreatment to 1 yearQuality of lifeMental statusMetastasis-free survivalBaseline to endCompletion of treatmentSalvage radiationSalvage radiotherapyOncological outcomesRadical prostatectomyClinically meaningful differencesSaint Louis University Mental Status ExamNear baselineClinically meaningful declineT-scoreHormonal domainsPatient-reported health-related quality of life (HRQoL) in the randomized FORMULA-509 trial of salvage radiotherapy and 6 months of GnRH agonist with either bicalutamide or abiraterone acetate plus prednisone (AAP) and apalutamide (Apa) after radical prostatectomy (RP).
Hoffman K, Nguyen P, Rathkopf D, Zurita A, Spratt D, Dess R, Liauw S, Szmulewitz R, Einstein D, Bubley G, Yu J, An Y, Wong A, Feng F, McKay R, Rose B, Shin K, Kibel A, Taplin M, Kollmeier M. Patient-reported health-related quality of life (HRQoL) in the randomized FORMULA-509 trial of salvage radiotherapy and 6 months of GnRH agonist with either bicalutamide or abiraterone acetate plus prednisone (AAP) and apalutamide (Apa) after radical prostatectomy (RP). Journal Of Clinical Oncology 2024, 42: 260-260. DOI: 10.1200/jco.2024.42.4_suppl.260.Peer-Reviewed Original ResearchAbiraterone acetate plus prednisoneSaint Louis University Mental Status ExamMonths of GnRH agonistPatient-reported health-related quality of lifeEPIC-26Radical prostatectomyHealth-related quality of lifeGnRH agonistTreatment armsHormonal functionPROMIS FatigueTreatment to 1 yearQuality of lifeAcetate plus prednisoneMental statusMetastasis-free survivalBaseline to endMental status examStandardized T scoresMild neurocognitive disorderCompletion of treatmentSalvage radiationSalvage radiotherapyOncological outcomesClinically meaningful differences
2021
Cost-Effectiveness of Adjuvant Treatment for Ductal Carcinoma In Situ
Gupta A, Jhawar SR, Sayan M, Yehia ZA, Haffty BG, Yu JB, Wang SY. Cost-Effectiveness of Adjuvant Treatment for Ductal Carcinoma In Situ. Journal Of Clinical Oncology 2021, 39: 2386-2396. PMID: 34019456, PMCID: PMC10166354, DOI: 10.1200/jco.21.00831.Peer-Reviewed Original ResearchConceptsAromatase inhibitorsTreatment strategiesRadiation treatmentDuctal carcinomaAge 40Risk reductionAdjuvant treatment strategiesGood-risk patientsLarge randomized trialsAdverse event ratesOptimal treatment strategyRelative risk reductionCohort of womenBreast cancer casesLow-value careQuality of lifeCost-effectiveness analysisBase-case resultsHormonal therapyAdjuvant treatmentMost patientsPatient ageSecondary malignanciesRandomized trialsRecurrence rate
2020
Did quality of life for older cancer survivors improve with the turn of the century in the United States?
Mahal AR, Cramer LD, Wang EH, Wang S, Davidoff AJ, Gross CP, Yu JB. Did quality of life for older cancer survivors improve with the turn of the century in the United States? Journal Of Geriatric Oncology 2020, 12: 102-105. PMID: 32535014, DOI: 10.1016/j.jgo.2020.05.010.Peer-Reviewed Original ResearchConceptsPhysical component summaryMental component summary scoresComponent summary scoresHealth utilityOlder patientsComponent summaryCancer survivorsLung cancerSummary scoresEarly era patientsLung cancer survivorsHealth-related qualityOlder cancer survivorsPopulation-based registryMedicare Advantage patientsLater eraQuality of lifeERA patientsAdvantage patientsMean agePatientsLongitudinal patientSimilar outcomesPropensity scoreCancer
2018
Bladder Preserving Trimodality Therapy for Muscle-Invasive Bladder Cancer
Johnson S, Yu J. Bladder Preserving Trimodality Therapy for Muscle-Invasive Bladder Cancer. Current Oncology Reports 2018, 20: 66. PMID: 29959582, DOI: 10.1007/s11912-018-0711-0.Peer-Reviewed Original ResearchConceptsBladder-preserving trimodality therapyTrimodality therapyRadical cystectomyBladder cancerMuscle-invasive urothelial carcinomaMuscle-invasive bladder cancerAlternative to cystectomySatisfactory quality of lifeBladder preservationOncological outcomesUrothelial carcinomaCystectomyFuture trialsBladderFunctional outcomesTherapyDisease outcomePatientsQuality of lifeTrimodalityCancerOutcomesCarcinomaA review of recent advances in the management of breast cancer related pain
Zocca J, Valimahomed A, Yu J, Gulati A. A review of recent advances in the management of breast cancer related pain. Breast Cancer Management 2018, 7: bmt08. DOI: 10.2217/bmt-2018-0003.Peer-Reviewed Original ResearchCancer related painEffects of breast cancerIncidence of breast cancerRelated painBreast cancerDelivery of carePain syndromeInterventional pain managementPatient's functional statusPain reliefQuality of lifeSymptom managementPhysical therapyImprove painPain managementFunctional statusFascial plane blocksDeath ratePainLong-term effectsPlane blockTargeted therapyBreastCancerRehabilitation
2017
Point: Which Treatment Modality for Localized Prostate Cancer Yields Superior Quality of Life: Radiotherapy or Prostatectomy? Quality of Life is Better After Modern Radiotherapy Compared With Surgery.
Yu J, Hamstra D. Point: Which Treatment Modality for Localized Prostate Cancer Yields Superior Quality of Life: Radiotherapy or Prostatectomy? Quality of Life is Better After Modern Radiotherapy Compared With Surgery. Oncology 2017, 31: 830-2, 835. PMID: 29179251.Peer-Reviewed Original Research
2016
Patient-Reported Quality of Life After Stereotactic Body Radiation Therapy Versus Moderate Hypofractionation for Clinically Localized Prostate Cancer
Johnson S, Soulos P, Shafman T, Mantz C, Dosoretz A, Ross R, Finkelstein S, Collins S, Suy S, Brower J, Ritter M, King C, Kupelian P, Horwitz E, Pollack A, Abramowitz M, Hallman M, Faria S, Gross C, Yu J. Patient-Reported Quality of Life After Stereotactic Body Radiation Therapy Versus Moderate Hypofractionation for Clinically Localized Prostate Cancer. International Journal Of Radiation Oncology • Biology • Physics 2016, 96: e242. DOI: 10.1016/j.ijrobp.2016.06.1232.Peer-Reviewed Original ResearchThe Effect of Marital Status on Health-Related Quality of Life in Elderly Patients Undergoing Radiation Therapy
Aneja S, Yu J. The Effect of Marital Status on Health-Related Quality of Life in Elderly Patients Undergoing Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2016, 96: s161. DOI: 10.1016/j.ijrobp.2016.06.389.Peer-Reviewed Original ResearchChanges in quality of life after radiation therapy for localized prostate cancer after dissemination of intensity modulated radiation therapy
Wang E, Wang S, Soulos P, Chen R, Kim S, Gross C, Yu J. Changes in quality of life after radiation therapy for localized prostate cancer after dissemination of intensity modulated radiation therapy. Journal Of Radiation Oncology 2016, 6: 295-300. DOI: 10.1007/s13566-016-0269-0.Peer-Reviewed Original ResearchExternal beam radiation therapyIntensity-modulated radiation therapyMental component scoreRadiation therapyProstate cancerEnd Results-Medicare Health Outcomes SurveyEra of IMRTComponent scoresImproved health-related qualityNonmetastatic prostate cancerPhysical component scoreHealth-related qualityHealth Outcomes SurveyStandard of careProstate cancer patientsExternal beam radiotherapyBeam radiation therapyQuality of lifeMethodsThe SurveillanceElderly patientsHRQOL measurementCancer patientsOutcome SurveyBeam radiotherapyLater eraDigital health application for real-time patient-reported outcomes during prostate radiotherapy.
Yang D, Thea J, An Y, Yu J. Digital health application for real-time patient-reported outcomes during prostate radiotherapy. Journal Of Clinical Oncology 2016, 34: 157-157. DOI: 10.1200/jco.2016.34.2_suppl.157.Peer-Reviewed Original ResearchPatient-reported outcomesQuality of lifeProstate radiotherapyTreatment periodExpanded Prostate Index CompositeClinical practice surveyDaily radiation treatmentsGenitourinary Cancers SymposiumFuture prospective studiesProstate cancer patientsClinical trial dataPatient Data CollectionPaucity of dataClinical research toolCancer SymposiumRoutine followPatient reportingProspective studySingle institutionCancer patientsClinical trialsSide effectsQOL domainsPatientsTrial data
2014
Decision Analysis of Stereotactic Radiation Surgery Versus Stereotactic Radiation Surgery and Whole-Brain Radiation Therapy for 1 to 3 Brain Metastases
Lester-Coll N, Dosoretz A, Yu J. Decision Analysis of Stereotactic Radiation Surgery Versus Stereotactic Radiation Surgery and Whole-Brain Radiation Therapy for 1 to 3 Brain Metastases. International Journal Of Radiation Oncology • Biology • Physics 2014, 89: 563-568. PMID: 24751412, DOI: 10.1016/j.ijrobp.2014.03.001.Peer-Reviewed Original ResearchConceptsWhole-brain radiation therapyStereotactic radiation surgeryQuality-adjusted life monthsQuality-adjusted life expectancyAdjuvant whole-brain radiation therapyBrain metastasesRadiation therapyRadiation surgeryPerformance statusOmission of whole-brain radiation therapyCompare quality-adjusted life expectancySalvage whole brain radiation therapySurveillance magnetic resonance imagingSide effectsQuality of lifeMarkov decision analysis modelControl intracranial diseaseIntracranial tumor controlPoor performance statusCohort of patientsNeurocognitive side effectsOne-way sensitivity analysesKarnofsky performance statusIntracranial progressionIntracranial relapse