2024
Improvements in Sleep Quality in Patients With Major Depressive and Generalized Anxiety Disorders Treated With Individualized, Parcel‐Guided Transcranial Magnetic Stimulation
Tang S, Holle J, Mor S, Dadario N, Ryan M, Teo C, Sughrue M, Yeung J. Improvements in Sleep Quality in Patients With Major Depressive and Generalized Anxiety Disorders Treated With Individualized, Parcel‐Guided Transcranial Magnetic Stimulation. Brain And Behavior 2024, 14: e70088. PMID: 39415644, PMCID: PMC11483549, DOI: 10.1002/brb3.70088.Peer-Reviewed Original ResearchConceptsGeneralized anxiety disorderRepetitive transcranial magnetic stimulationCentral executive networkGeneralized Anxiety Disorder-7Affective disordersBeck Depression InventoryAnxiety disordersTheta burst stimulationTranscranial magnetic stimulationPittsburgh Sleep Quality IndexDorsolateral prefrontal cortexIndividualized repetitive transcranial magnetic stimulationRTMS targetsMagnetic stimulationIntermittent theta burst stimulationFunctional connectivity networksPrefrontal cortexDepressive disorderMajor depressionAffective symptomsQuality of lifeAnxiety symptomsExecutive networkDepression InventorySleep Quality IndexUp-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity
Zhang T, Yu W, Cheng X, Yeung J, Ahumada V, Norris P, Pearson M, Yang X, van Deursen W, Halcovich C, Nassar A, Vesely M, Zhang Y, Zhang J, Ji L, Flies D, Liu L, Langermann S, LaRochelle W, Humphrey R, Zhao D, Zhang Q, Zhang J, Gu R, Schalper K, Sanmamed M, Chen L. Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity. Science Immunology 2024, 9: eadh2334. PMID: 38669316, DOI: 10.1126/sciimmunol.adh2334.Peer-Reviewed Original ResearchConceptsT cell infiltrationT cell exclusionT cellsResistance to anti-PD-1 immunotherapyPoor T-cell infiltrationAnti-PD-1 immunotherapyImmunogenic mouse tumorsT cell mobilizationHuman cancer tissuesTherapeutic immunotherapyCancer immunotherapyMouse tumorsChemokine systemImmunotherapyTumor tissuesImpaired infiltrationTumorLipid metabolitesHuman cancersCancer tissuesInfiltrationA2 groupCancerPLA2G10Up-regulated
2023
Personalized, parcel‐guided rTMS for the treatment of major depressive disorder: Safety and proof of concept
Tang S, Holle J, Dadario N, Lesslar O, Teo C, Ryan M, Sughrue M, Yeung J. Personalized, parcel‐guided rTMS for the treatment of major depressive disorder: Safety and proof of concept. Brain And Behavior 2023, 13: e3268. PMID: 37798655, PMCID: PMC10636393, DOI: 10.1002/brb3.3268.Peer-Reviewed Original ResearchConceptsRepetitive transcranial magnetic stimulationQuality of lifeBeck Depression InventoryTreatment-resistant depressionComorbidity of depressionMajor depressive disorderTranscranial magnetic stimulationMultiple cortical targetsDorsolateral prefrontal cortexRTMS treatmentSignificant remissionRetrospective reviewDepressive disorderPatient outcomesCortical targetsMagnetic stimulationPlacebo effectPatientsUS FoodDrug AdministrationControl groupDepression symptomsDepression InventoryFunctional connectivity networksPrefrontal cortexTopology of the lateral visual system: The fundus of the superior temporal sulcus and parietal area H connect nonvisual cerebrum to the lateral occipital lobe
Dadario N, Tanglay O, Stafford J, Davis E, Young I, Fonseka R, Briggs R, Yeung J, Teo C, Sughrue M. Topology of the lateral visual system: The fundus of the superior temporal sulcus and parietal area H connect nonvisual cerebrum to the lateral occipital lobe. Brain And Behavior 2023, 13: e2945. PMID: 36912573, PMCID: PMC10097165, DOI: 10.1002/brb3.2945.Peer-Reviewed Original ResearchConceptsActivation likelihood estimationHub-like regionsLateral occipital lobeOccipital lobeVisual networkSuperior temporal sulcusTask-based functional MRI studiesTemporal sulcusTemporo-occipital regionsFunctional MRI studyCortical parcellation schemeMeta-analytic softwareClinical significanceFunctional roleLanguage cortexMRI studiesAbnormal activationCortical regionsVisual systemFunctional coactivationCerebrumCortexPossible important roleParcellation schemesStructural connectivity
2022
Improving quality of life post-tumor craniotomy using personalized, parcel-guided TMS: safety and proof of concept
Tang S, Holle J, Lesslar O, Teo C, Sughrue M, Yeung J. Improving quality of life post-tumor craniotomy using personalized, parcel-guided TMS: safety and proof of concept. Journal Of Neuro-Oncology 2022, 160: 413-422. PMID: 36308593, DOI: 10.1007/s11060-022-04160-y.Peer-Reviewed Original ResearchConceptsRepetitive transcranial magnetic stimulationNeuro-cognitive dysfunctionRTMS treatmentBeck Depression InventoryFunctional deficitsNeurological disordersDepression InventoryPost-operative depressionTranscranial magnetic stimulationNeuro-cognitive deficitsNeuro-cognitive functionsMultiple cortical targetsFunctional connectivity approachNon-invasive toolEuroQol qualityNeuropsychiatric questionnaireResultsNine patientsAdverse eventsRetrospective reviewSurgical removalTMS treatmentCortical targetsShort-term memory difficultiesBrain tumorsDepressive symptoms
2021
Surgical treatment of symptomatic pineal cysts without hydrocephalus—meta-analysis of the published literature
Masina R, Ansaripour A, Beneš V, Berhouma M, Choque-Velasquez J, Eide P, Fedorko S, Fleck S, Hernesniemi J, Koziarski A, Májovský M, Podgorski A, Schroeder H, Teo C, Unterberg A, Yeung J, Kolias A, Santarius T. Surgical treatment of symptomatic pineal cysts without hydrocephalus—meta-analysis of the published literature. Acta Neurochirurgica 2021, 164: 61-77. PMID: 34854993, PMCID: PMC8761144, DOI: 10.1007/s00701-021-05054-0.Peer-Reviewed Original ResearchConceptsSymptomatic pineal cystsPineal cystsCase reportCyst sizeSingle-center retrospective cohortChronic incisional painLarger cyst sizeRetrospective surgical seriesOverall complication rateRole of surgeryVertigo/dizzinessMean cyst sizeLoss of consciousnessObjective outcome assessmentNausea/vomitSupracerebellar infratentorial approachAssessment of outcomesMajority of casesIncisional painComplication rateFocal neurologyGait disturbanceMost patientsPatient characteristicsRetrospective cohortUsing Quicktome for Intracerebral Surgery: Early Retrospective Study and Proof of Concept
Yeung JT, Taylor HM, Nicholas PJ, Young IM, Jiang I, Doyen S, Sughrue ME, Teo C. Using Quicktome for Intracerebral Surgery: Early Retrospective Study and Proof of Concept. World Neurosurgery 2021, 154: e734-e742. PMID: 34358688, DOI: 10.1016/j.wneu.2021.07.127.Peer-Reviewed Original ResearchConceptsIntracerebral surgeryNeurologic deficitsNew postoperative neurologic deficitsCases of leukoencephalopathyNew neurologic deficitsHigh-risk patientsPostoperative neurologic deficitsPostoperative neurologic outcomeIntra-axial tumorsFunctional localizationBrain networksEarlier retrospective studiesCritical brain networksDefault mode networkPostoperative strokeNeurologic outcomeMedian ageNeurological deficitsPreoperative findingsNew deficitsRetrospective studyPostsurgical outcomesIntracranial surgeryNeuronavigation platformStandard neuronavigationOptimal timing of post-operative enoxaparin after neurosurgery: A single institution experience
Briggs RG, Lin YH, Dadario NB, Young IM, Conner AK, Xu W, Tanglay O, Kim SJ, Fonseka RD, Bonney PA, Chakraborty AR, Nix CE, Flecher LR, Yeung JT, Teo C, Sughrue ME. Optimal timing of post-operative enoxaparin after neurosurgery: A single institution experience. Clinical Neurology And Neurosurgery 2021, 207: 106792. PMID: 34233235, DOI: 10.1016/j.clineuro.2021.106792.Peer-Reviewed Original ResearchConceptsDeep vein thrombosisLower extremity deep vein thrombosisExtremity deep vein thrombosisIntracranial tumor resectionVenous thromboembolismAnticoagulant prophylaxisProphylactic enoxaparinTumor resectionImmediate post-operative periodMultivariate binomial logistic regression analysisNon-anticoagulation groupSingle institution experiencePost-operative periodPossible risk factorsPost-operative brain tumor patientsEvidence-based protocolsBrain tumor patientsLogistic regression analysisHigh-grade gliomasBinomial logistic regression analysisVTE complicationsElective craniotomyMedical comorbiditiesPulmonary embolismAdult patientsA connectivity model of the anatomic substrates underlying ideomotor apraxia: A meta-analysis of functional neuroimaging studies
O'Neal CM, Ahsan SA, Dadario NB, Fonseka RD, Young IM, Parker A, Maxwell BD, Yeung JT, Briggs RG, Teo C, Sughrue ME. A connectivity model of the anatomic substrates underlying ideomotor apraxia: A meta-analysis of functional neuroimaging studies. Clinical Neurology And Neurosurgery 2021, 207: 106765. PMID: 34237682, DOI: 10.1016/j.clineuro.2021.106765.Peer-Reviewed Original ResearchTargeting the CSF1/CSF1R axis is a potential treatment strategy for malignant meningiomas
Yeung J, Yaghoobi V, Miyagishima D, Vesely MD, Zhang T, Badri T, Nassar A, Han X, Sanmamed MF, Youngblood M, Peyre M, Kalamarides M, Rimm DL, Gunel M, Chen L. Targeting the CSF1/CSF1R axis is a potential treatment strategy for malignant meningiomas. Neuro-Oncology 2021, 23: 1922-1935. PMID: 33914067, PMCID: PMC8563319, DOI: 10.1093/neuonc/noab075.Peer-Reviewed Original ResearchConceptsColony-stimulating factor-1Myeloid cellsMalignant meningiomasTumor microenvironmentCSF1/CSF1RRNA-seqRNA sequencingHuman meningiomasImmune subsetsGene expressionT cellsTreatment strategiesNormalization cancer immunotherapyImportant regulatorCell typesNovel immunocompetent murine modelDeath ligand 1 (PD-L1) expressionCell death receptor-1Immunosuppressive myeloid cellsDeath receptor-1Ligand 1 expressionFactor 1Immune cell typesImmunocompetent murine modelEffective treatment strategiesResection of Symptomatic Pineal Cysts Provides Durable Clinical Improvement: A Breakdown of Presenting Symptoms and Lessons Learned
Yeung JT, Young IM, Profyris C, Katsos K, Sughrue ME, Teo C. Resection of Symptomatic Pineal Cysts Provides Durable Clinical Improvement: A Breakdown of Presenting Symptoms and Lessons Learned. World Neurosurgery 2021, 150: e668-e674. PMID: 33771749, DOI: 10.1016/j.wneu.2021.03.087.Peer-Reviewed Original ResearchConceptsSymptomatic pineal cystsPineal cystsSurgical resectionClinical improvementDurable clinical improvementExhaustive conservative managementNon-headache symptomsDurable symptomatic reliefYears of agePresenting symptomConservative managementSymptomatic patientsSurgical candidacySymptomatic reliefVisual disturbancesClinical outcomesPatient populationRadiographic changesCerebral aqueductRetrospective analysisResectionPatientsVariable symptomsCystsHeadacheRadical Exenteration of the Skull Base for End-Stage, Locally Advanced Sinonasal Malignancies: Challenging the Dictum of Unresectability
Yeung JT, Caminer DM, Young IM, Sughrue ME, Teo C. Radical Exenteration of the Skull Base for End-Stage, Locally Advanced Sinonasal Malignancies: Challenging the Dictum of Unresectability. World Neurosurgery 2021, 150: e102-e107. PMID: 33647490, DOI: 10.1016/j.wneu.2021.02.092.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCarcinomaCarcinoma, Adenoid CysticChildEsthesioneuroblastoma, OlfactoryFemaleHumansMaleMaxillary Sinus NeoplasmsMiddle AgedNasopharyngeal CarcinomaNeoplasm StagingNeurofibrosarcomaNeurosurgical ProceduresNose NeoplasmsOsteosarcomaParanasal Sinus NeoplasmsProgression-Free SurvivalSalvage TherapySarcomaSkull BaseSquamous Cell Carcinoma of Head and NeckSurvival RateYoung AdultConceptsAdvanced sinonasal cancerSinonasal cancerPerioperative complicationsSalvage surgeryIntracranial involvementSingle-center retrospective reviewAdvanced sinonasal malignanciesAdvanced sinonasal tumorsDetails of chemotherapyRadical salvage surgerySalvage surgical resectionRole of surgeryPrior surgeryOverall survivalPatient demographicsSurgical resectionRetrospective reviewAggressive diseasePalliative careSinonasal malignanciesSurvival outcomesSurgical approachTreatment optionsIntracranial invasionSinonasal tumorsSpatially Resolved and Quantitative Analysis of the Immunological Landscape in Human Meningiomas
Yeung J, Yaghoobi V, Aung TN, Vesely MD, Zhang T, Gaule P, Gunel M, Rimm DL, Chen L. Spatially Resolved and Quantitative Analysis of the Immunological Landscape in Human Meningiomas. Journal Of Neuropathology & Experimental Neurology 2021, 80: 150-159. PMID: 33393633, DOI: 10.1093/jnen/nlaa152.Peer-Reviewed Original ResearchConceptsPD-L1 expressionT cell infiltrationPD-L1PD-L2Human meningiomasTumor-infiltrating immune cell populationsHigh PD-L1 expressionT-cell activation/proliferationActivation/dysfunctionLevels of CD3Immune cell subsetsT-cell phenotypeImmune cell populationsHigh-grade tumorsActivation/proliferationHigher CD3TIL infiltrationCD8 ratioImmunotherapeutic strategiesCell subsetsImmunological statusGrade tumorsImmunological landscapeTissue microarrayMacrophage phenotypeAnatomy and White Matter Connections of the Parahippocampal Gyrus
Lin YH, Dhanaraj V, Mackenzie AE, Young IM, Tanglay O, Briggs RG, Chakraborty AR, Hormovas J, Fonseka RD, Kim SJ, Yeung JT, Teo C, Sughrue ME. Anatomy and White Matter Connections of the Parahippocampal Gyrus. World Neurosurgery 2021, 148: e218-e226. PMID: 33412321, DOI: 10.1016/j.wneu.2020.12.136.Peer-Reviewed Original Research
2020
Unexpected hubness: a proof-of-concept study of the human connectome using pagerank centrality and implications for intracerebral neurosurgery
Yeung JT, Taylor HM, Young IM, Nicholas PJ, Doyen S, Sughrue ME. Unexpected hubness: a proof-of-concept study of the human connectome using pagerank centrality and implications for intracerebral neurosurgery. Journal Of Neuro-Oncology 2020, 151: 249-256. PMID: 33170473, DOI: 10.1007/s11060-020-03659-6.Peer-Reviewed Original ResearchConceptsIntracerebral surgeryHealthy cohortSubset of individualsSupratentorial neurosurgeryCohortBrain regionsHuman connectomeParcellation schemesParcellationNeurosurgeryConcept studyPersonalized levelPotential effectsConnectomeSurgeryQuartile rankMethodsWePrevalenceResultsInIndividualsBrainNeurosurgeonsThe Surgical Resection of Brainstem Glioma: Outcomes and Prognostic Factors
Faulkner H, Arnaout O, Hoshide R, Young IM, Yeung JT, Sughrue ME, Teo C. The Surgical Resection of Brainstem Glioma: Outcomes and Prognostic Factors. World Neurosurgery 2020, 146: e639-e650. PMID: 33152495, DOI: 10.1016/j.wneu.2020.10.147.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAstrocytomaAtaxiaBrain Stem NeoplasmsCerebrospinal Fluid LeakChildChild, PreschoolDiplopiaEpendymomaFemaleGlioblastomaGliomaHeadacheHumansHydrocephalusInfantInfant, NewbornKaplan-Meier EstimateKarnofsky Performance StatusMachine LearningMagnetic Resonance ImagingMaleMiddle AgedMultivariate AnalysisNauseaNeoplasm GradingNeoplasm, ResidualNeurosurgical ProceduresPostoperative ComplicationsPrognosisRetrospective StudiesSurvival RateTumor BurdenVomitingYoung AdultConceptsBrainstem gliomasSurgical resectionPrognostic factorsSurgical treatmentTransient neurologic deficitsRadical surgical resectionHigh-grade tumorsPostoperative radiographic evaluationMagnetic resonance imagingChart reviewNeurologic deficitsOverall survivalSurgical candidatesConfers survival advantageMedian ageSurgical indicationsPatient selectionSurvival outcomesRadiographic evaluationSelect subgroupRadiographic featuresPrimary treatmentPermanent deficitsSurvival advantageTreatment selectionClinical and economic burden of neurofibromatosis type 2 in the United States
Koo AB, Yeung JT, Freedman IG, Lee JH, Ahmed OM, Ma AK, Miyagishima DF, DiLuna M, Kahle K. Clinical and economic burden of neurofibromatosis type 2 in the United States. Clinical Neurology And Neurosurgery 2020, 197: 106053. PMID: 32683193, DOI: 10.1016/j.clineuro.2020.106053.Peer-Reviewed Original ResearchConceptsOpen resectionPatient demographicsRisk factorsMeningioma resectionMulti-year cross-sectional studyNeurofibromatosis type 2 (NF2) patientsSpine tumor resectionCommon admission diagnosesNational Inpatient SampleType 2 patientsCross-sectional studySignificant independent associationNeurofibromatosis type 2Regression analysisInflation-adjusted costAdmission diagnosisHospital stayDischarge weightIndependent predictorsObstructive hydrocephalusSurgical interventionDiagnosis codesHospital characteristicsInpatient populationInpatient SampleIn silico analysis of the immunological landscape of pituitary adenomas
Yeung JT, Vesely MD, Miyagishima DF. In silico analysis of the immunological landscape of pituitary adenomas. Journal Of Neuro-Oncology 2020, 147: 595-598. PMID: 32236778, PMCID: PMC7261241, DOI: 10.1007/s11060-020-03476-x.Peer-Reviewed Original ResearchConceptsPituitary adenomasImmunological landscapeImmune cellsM2 macrophagesPituitary tumorsAdenoma subtypesSilent pituitary tumorsMemory T cellsImmune cell typesDifferent immunotherapiesHigh CD8Immune infiltratesImmune landscapeSilent tumorsGH tumorsImmunological compositionMacrophage fractionT cellsMast cellsTumor subtypesSolid tumorsSubclinical casesAdenomasTumorsSubtypes
2016
Macrovascular Lesions Underlying Spontaneous Intracerebral Hemorrhage
Yeung J, Cord BJ, O'Rourke TK, Maina RM, Sommaruga S, Matouk CC. Macrovascular Lesions Underlying Spontaneous Intracerebral Hemorrhage. Seminars In Neurology 2016, 36: 244-253. PMID: 27214699, DOI: 10.1055/s-0036-1581994.Peer-Reviewed Original ResearchConceptsSpontaneous intracerebral hemorrhageIntracerebral hemorrhageMacrovascular lesionsHigh case fatality rateCranial dural arteriovenous fistulasBrain arteriovenous malformationsCase fatality rateDural arteriovenous fistulaEtiology of hemorrhageCerebral cavernous malformationsRehemorrhage rateArteriovenous fistulaMorbid diseaseArteriovenous malformationsCavernous malformationsFatality rateClinical decisionHemorrhageLesionsMalformationsFistulaPrognosisAneurysmsEtiologyDiseaseHigh-resolution Vessel Wall Magnetic Resonance Imaging in Intracranial Aneurysms and Brain Arteriovenous Malformations
Matouk CC, Cord BJ, Yeung J, Malhotra A, Johnson MH, Minja FJ. High-resolution Vessel Wall Magnetic Resonance Imaging in Intracranial Aneurysms and Brain Arteriovenous Malformations. Topics In Magnetic Resonance Imaging 2016, 25: 49-55. PMID: 27049241, DOI: 10.1097/rmr.0000000000000084.Peer-Reviewed Original ResearchConceptsHigh-resolution vessel wall magnetic resonance imagingVessel wall magnetic resonance imagingMagnetic resonance imagingArteriovenous malformationsResonance imagingIntracranial aneurysmsSteno-occlusive diseaseBrain arteriovenous malformationsCerebrovascular diseaseClinical evaluationAcademic centersClinical practiceVW-MRIConventional imagingAneurysmsMalformationsDisease