2022
Delayed, Progressive Multivessel Occlusion After Resection of a Recurrent Glioma
Tanglay O, Dadario N, Young I, Yeung J, Teo C, Sughrue M, Yeung J. Delayed, Progressive Multivessel Occlusion After Resection of a Recurrent Glioma. Cureus 2022, 14: e33019. PMID: 36721529, PMCID: PMC9879796, DOI: 10.7759/cureus.33019.Peer-Reviewed Original ResearchMagnetic resonance imagingCerebral artery infarctionArtery infarctionGlioma resectionGlioblastoma multiformeMiddle cerebral artery infarctionPreoperative magnetic resonance imagingCommon primary brain tumorPosterior cerebral artery infarctionAggressive cytoreductive surgeryAggressive natural historyMiddle cerebral arteryPrimary brain tumorsMost clinical researchMultivessel occlusionCytoreductive surgeryAdjuvant radiochemotherapyMedian survivalNeurologic declineOverall survivalTotal resectionVascular etiologyCerebral arteryPatient outcomesClinical guidance
2021
Radical Exenteration of the Skull Base for End-Stage, Locally Advanced Sinonasal Malignancies: Challenging the Dictum of Unresectability
Yeung JT, Caminer DM, Young IM, Sughrue ME, Teo C. Radical Exenteration of the Skull Base for End-Stage, Locally Advanced Sinonasal Malignancies: Challenging the Dictum of Unresectability. World Neurosurgery 2021, 150: e102-e107. PMID: 33647490, DOI: 10.1016/j.wneu.2021.02.092.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCarcinomaCarcinoma, Adenoid CysticChildEsthesioneuroblastoma, OlfactoryFemaleHumansMaleMaxillary Sinus NeoplasmsMiddle AgedNasopharyngeal CarcinomaNeoplasm StagingNeurofibrosarcomaNeurosurgical ProceduresNose NeoplasmsOsteosarcomaParanasal Sinus NeoplasmsProgression-Free SurvivalSalvage TherapySarcomaSkull BaseSquamous Cell Carcinoma of Head and NeckSurvival RateYoung AdultConceptsAdvanced sinonasal cancerSinonasal cancerPerioperative complicationsSalvage surgeryIntracranial involvementSingle-center retrospective reviewAdvanced sinonasal malignanciesAdvanced sinonasal tumorsDetails of chemotherapyRadical salvage surgerySalvage surgical resectionRole of surgeryPrior surgeryOverall survivalPatient demographicsSurgical resectionRetrospective reviewAggressive diseasePalliative careSinonasal malignanciesSurvival outcomesSurgical approachTreatment optionsIntracranial invasionSinonasal tumors
2020
The Surgical Resection of Brainstem Glioma: Outcomes and Prognostic Factors
Faulkner H, Arnaout O, Hoshide R, Young IM, Yeung JT, Sughrue ME, Teo C. The Surgical Resection of Brainstem Glioma: Outcomes and Prognostic Factors. World Neurosurgery 2020, 146: e639-e650. PMID: 33152495, DOI: 10.1016/j.wneu.2020.10.147.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAstrocytomaAtaxiaBrain Stem NeoplasmsCerebrospinal Fluid LeakChildChild, PreschoolDiplopiaEpendymomaFemaleGlioblastomaGliomaHeadacheHumansHydrocephalusInfantInfant, NewbornKaplan-Meier EstimateKarnofsky Performance StatusMachine LearningMagnetic Resonance ImagingMaleMiddle AgedMultivariate AnalysisNauseaNeoplasm GradingNeoplasm, ResidualNeurosurgical ProceduresPostoperative ComplicationsPrognosisRetrospective StudiesSurvival RateTumor BurdenVomitingYoung AdultConceptsBrainstem gliomasSurgical resectionPrognostic factorsSurgical treatmentTransient neurologic deficitsRadical surgical resectionHigh-grade tumorsPostoperative radiographic evaluationMagnetic resonance imagingChart reviewNeurologic deficitsOverall survivalSurgical candidatesConfers survival advantageMedian ageSurgical indicationsPatient selectionSurvival outcomesRadiographic evaluationSelect subgroupRadiographic featuresPrimary treatmentPermanent deficitsSurvival advantageTreatment selectionTumor Location and Treatment Modality are Associated with Overall Survival in Adult Medulloblastoma
K A, Freedman I, Lee JH, Miyagishima D, Ahmed O, Yeung J. Tumor Location and Treatment Modality are Associated with Overall Survival in Adult Medulloblastoma. Cureus 2020, 12: e7061. PMID: 32226663, PMCID: PMC7089624, DOI: 10.7759/cureus.7061.Peer-Reviewed Original ResearchTumor locationOverall survivalAdult medulloblastomaPrognostic factorsAdult casesTreatment modalitiesSurvival timeMultivariate Cox proportional hazards modelWorse median survival timeCox proportional hazards modelOverall median survivalSignificant prognostic factorsBetter overall survivalEnd Results registryMedian survival timeMultivariate survival analysisUnited States SurveillanceProportional hazards modelCourse of treatmentAggressive brain tumorYears of ageMedian survivalSEER registryShorter survivalClinical variables
2016
Impact of Deferring Radiation Therapy in Patients With Epidermal Growth Factor Receptor–Mutant Non-Small Cell Lung Cancer Who Develop Brain Metastases
Magnuson WJ, Yeung JT, Guillod PD, Gettinger SN, Yu JB, Chiang VL. Impact of Deferring Radiation Therapy in Patients With Epidermal Growth Factor Receptor–Mutant Non-Small Cell Lung Cancer Who Develop Brain Metastases. International Journal Of Radiation Oncology • Biology • Physics 2016, 95: 673-679. PMID: 27034176, DOI: 10.1016/j.ijrobp.2016.01.037.Peer-Reviewed Original ResearchConceptsWhole-brain radiation therapyUpfront EGFR-TKIIntracranial progression-free survivalUpfront radiation therapyProgression-free survivalBrain metastasesEGFR-TKI groupEGFR-TKIEGFR-mutant NSCLCOverall survivalRadiation therapyEpidermal Growth Factor Receptor–Mutant NonDisease-specific Graded Prognostic AssessmentUpfront EGFR tyrosine kinase inhibitorsEGFR-TKI resistance mutationSmall cell lung cancerEGFR tyrosine kinase inhibitorsEGFR-TKI useMedian overall survivalSimilar overall survivalUpfront RT groupInferior overall survivalCell lung cancerMutant lung adenocarcinomaEpidermal growth factor receptor
2013
LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma
Yeung JT, Hamilton RL, Ohnishi K, Ikeura M, Potter DM, Nikiforova MN, Ferrone S, Jakacki RI, Pollack IF, Okada H. LOH in the HLA Class I Region at 6p21 Is Associated with Shorter Survival in Newly Diagnosed Adult Glioblastoma. Clinical Cancer Research 2013, 19: 1816-1826. PMID: 23401227, PMCID: PMC3618546, DOI: 10.1158/1078-0432.ccr-12-2861.Peer-Reviewed Original ResearchConceptsHLA class IT cell infiltrationHLA class IILoss of heterozygosityHLA class IIIClass IOverall survivalAdult glioblastomaClass IIIHLA class I expressionHuman leukocyte antigen (HLA) class IClass IIEfficacy of immunotherapyShorter overall survivalCytotoxic T cellsClass I expressionAntigen class ICross-sectional analysisAdult patientsShorter survivalImmunohistochemical evaluationT cellsHLA class I regionI expressionDownregulated expression