Jacky Yeung, MD, FAANS
Assistant Professor, NeurosurgeryCards
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Titles
Assistant Professor, Neurosurgery
Biography
Dr. Jacky Yeung is a board-certified, fellowship-trained neurosurgeon who started residency in neurosurgery in 2013 after completing undergraduate studies at University of British Columbia in Honors Physiology and his MD degree at Michigan State University College of Human Medicine. He is a member of the American Association of Neurological Surgeons and was elected to the AANS Young Neurosurgeons Committee in 2016. He obtained his fellowship training at the Centre for Minimally Invasive Neurosurgery in Sydney, Australia under Dr. Charles Teo. During that time, he published widely on the use of machine learning to study the human functional connectome and was the first neurosurgeon to publish on the use of personalized pre-operative brain mapping during intracerebral surgeries. Moreover, Dr. Yeung's breadth of expertise is further highlighted by his authorship in the book "Connectomic Medicine," which dives into advancing understanding in connectomics, a field integral to his research endeavors, particularly in the study of the human functional connectome.
He was the recipient of the prestigious Doris Duke Clinical Research Fellowship. As a tumor immunologist, he identified the presence of specific antigens in childhood and adult ependymomas, which led to a NIH-funded clinical trial utilizing a peptide vaccine (#NCT01795313). He focused on mechanisms of immune escape in adult gliomas, specifically the relationship between LOH of HLA Class I and decreased survival in GBM patients. During residency, he was the recipient of the prestigious AANS Tumor Section Research Award and focused on identifying novel immune check-point molecules under the mentorship of Lieping Chen, MD, PhD. To date, he has characterized the tumor immune microenvironment in malignant meningiomas and identified a major mechanism by which these tumors evades anti-tumor immunity. He has published widely in prestigious journals such as Clinical Cancer Research, Journal of Neuro-oncology, Neuro-Oncology, and Science Immunology.
In addition to his extensive work in tumor immunology and machine learning applications in neurosurgery, Dr. Yeung has also developed a significant expertise in endoscopic cranial and spinal surgery. He is one of the few surgeons in the country to have endoscopic expertise in the treatment for both brain and spinal disorders. His proficiency in this area is further demonstrated through his national lectures, where he shares his knowledge and techniques with fellow neurosurgeons, contributing to the advancement of minimally invasive neurosurgical practices.
Appointments
Neurosurgery
Assistant ProfessorPrimary
Other Departments & Organizations
- Chen Lab
- Neurosurgery
- Yale Medicine
Education & Training
- Fellowship
- Centre for Minimally Invasive Neurosurgery (2021)
- Residency
- Yale-New Haven Hospital (2020)
- MD
- Michigan State University College of Human Medicin (2013)
- Doris Duke Clinical Research Fellow
- University of Pittsburgh (2012)
- BSc (Hon)
- University of British Columbia, Physiology (2008)
Research
Overview
1) Tumor immunology: To study how brain tumors evade anti-tumor immunity by exclusion of cytotoxic T cells
2) Functional connectomics: Leverage machine learning to understand the human functional connectome during health and disease and to facilitate connectome-based interventional neurorehabilitation (transcranial magnetic stimulation)
Medical Research Interests
Research at a Glance
Yale Co-Authors
Publications Timeline
Danielle Miyagishima, PhD
Matthew Vesely, MD, PhD
Andrew Koo, MD
Charles Matouk, MD
David Rimm, MD, PhD
Murat Günel, MD, FACS, FAHA, FAANS
Publications
2024
Improvements in Sleep Quality in Patients With Major Depressive and Generalized Anxiety Disorders Treated With Individualized, Parcel‐Guided Transcranial Magnetic Stimulation
Tang S, Holle J, Mor S, Dadario N, Ryan M, Teo C, Sughrue M, Yeung J. Improvements in Sleep Quality in Patients With Major Depressive and Generalized Anxiety Disorders Treated With Individualized, Parcel‐Guided Transcranial Magnetic Stimulation. Brain And Behavior 2024, 14: e70088. PMID: 39415644, PMCID: PMC11483549, DOI: 10.1002/brb3.70088.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsGeneralized anxiety disorderRepetitive transcranial magnetic stimulationCentral executive networkGeneralized Anxiety Disorder-7Affective disordersBeck Depression InventoryAnxiety disordersTheta burst stimulationTranscranial magnetic stimulationPittsburgh Sleep Quality IndexDorsolateral prefrontal cortexIndividualized repetitive transcranial magnetic stimulationRTMS targetsMagnetic stimulationIntermittent theta burst stimulationFunctional connectivity networksPrefrontal cortexDepressive disorderMajor depressionAffective symptomsQuality of lifeAnxiety symptomsExecutive networkDepression InventorySleep Quality IndexPersonalized, parcel-guided non-invasive transcranial magnetic stimulation for the treatment of post-concussive syndrome: safety and proof of concept
Tang S, Holle J, Dadario N, Ryan M, Lesslar O, Teo C, Sughrue M, Yeung J. Personalized, parcel-guided non-invasive transcranial magnetic stimulation for the treatment of post-concussive syndrome: safety and proof of concept. Brain Injury 2024, 38: 1015-1025. PMID: 38965876, DOI: 10.1080/02699052.2024.2371975.Peer-Reviewed Original ResearchConceptsRepetitive transcranial magnetic stimulationPost-concussion syndromeTraumatic brain injuryTranscranial magnetic stimulationFollow-upRivermead Post-Concussion Symptoms QuestionnaireGeneralized Anxiety Disorder-7 scorePost-Concussion Symptoms QuestionnaireRTMS targetsBeck Depression InventoryMagnetic stimulationSevere traumatic brain injuryEQ-5DNon-invasive transcranial magnetic stimulationClinically significant reductionMeasures of quality of lifeTreatment of post-concussion syndromePCS symptomsDepression InventoryRetrospective reviewOff-labelIndividual symptomsHealthy controlsPatientsControlled studiesUp-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity
Zhang T, Yu W, Cheng X, Yeung J, Ahumada V, Norris P, Pearson M, Yang X, van Deursen W, Halcovich C, Nassar A, Vesely M, Zhang Y, Zhang J, Ji L, Flies D, Liu L, Langermann S, LaRochelle W, Humphrey R, Zhao D, Zhang Q, Zhang J, Gu R, Schalper K, Sanmamed M, Chen L. Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity. Science Immunology 2024, 9: eadh2334. PMID: 38669316, DOI: 10.1126/sciimmunol.adh2334.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsT cell infiltrationT cell exclusionT cellsResistance to anti-PD-1 immunotherapyPoor T-cell infiltrationAnti-PD-1 immunotherapyImmunogenic mouse tumorsT cell mobilizationHuman cancer tissuesTherapeutic immunotherapyCancer immunotherapyMouse tumorsChemokine systemImmunotherapyTumor tissuesImpaired infiltrationTumorLipid metabolitesHuman cancersCancer tissuesInfiltrationA2 groupCancerPLA2G10Up-regulated
2023
Editorial: Prevalence of pineal cysts in healthy individuals: Emphasis on size, morphology and pineal recess crowding.
Tang SJ, Yeung JT. Editorial: Prevalence of pineal cysts in healthy individuals: Emphasis on size, morphology and pineal recess crowding. J Neurol Sci 2023, 453: 120820. PMID: 37804791, DOI: 10.1016/j.jns.2023.120820.Peer-Reviewed Original ResearchPersonalized, parcel‐guided rTMS for the treatment of major depressive disorder: Safety and proof of concept
Tang S, Holle J, Dadario N, Lesslar O, Teo C, Ryan M, Sughrue M, Yeung J. Personalized, parcel‐guided rTMS for the treatment of major depressive disorder: Safety and proof of concept. Brain And Behavior 2023, 13: e3268. PMID: 37798655, PMCID: PMC10636393, DOI: 10.1002/brb3.3268.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRepetitive transcranial magnetic stimulationQuality of lifeBeck Depression InventoryTreatment-resistant depressionComorbidity of depressionMajor depressive disorderTranscranial magnetic stimulationMultiple cortical targetsDorsolateral prefrontal cortexRTMS treatmentSignificant remissionRetrospective reviewDepressive disorderPatient outcomesCortical targetsMagnetic stimulationPlacebo effectPatientsUS FoodDrug AdministrationControl groupDepression symptomsDepression InventoryFunctional connectivity networksPrefrontal cortexTopology of the lateral visual system: The fundus of the superior temporal sulcus and parietal area H connect nonvisual cerebrum to the lateral occipital lobe
Dadario N, Tanglay O, Stafford J, Davis E, Young I, Fonseka R, Briggs R, Yeung J, Teo C, Sughrue M. Topology of the lateral visual system: The fundus of the superior temporal sulcus and parietal area H connect nonvisual cerebrum to the lateral occipital lobe. Brain And Behavior 2023, 13: e2945. PMID: 36912573, PMCID: PMC10097165, DOI: 10.1002/brb3.2945.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsActivation likelihood estimationHub-like regionsLateral occipital lobeOccipital lobeVisual networkSuperior temporal sulcusTask-based functional MRI studiesTemporal sulcusTemporo-occipital regionsFunctional MRI studyCortical parcellation schemeMeta-analytic softwareClinical significanceFunctional roleLanguage cortexMRI studiesAbnormal activationCortical regionsVisual systemFunctional coactivationCerebrumCortexPossible important roleParcellation schemesStructural connectivityConnectivity model of the anatomic substrates and network abnormalities in major depressive disorder: A coordinate meta-analysis of resting-state functional connectivity
Young I, Dadario N, Tanglay O, Chen E, Cook B, Taylor H, Crawford L, Yeung J, Nicholas P, Doyen S, Sughrue M. Connectivity model of the anatomic substrates and network abnormalities in major depressive disorder: A coordinate meta-analysis of resting-state functional connectivity. Journal Of Affective Disorders Reports 2023, 11: 100478. DOI: 10.1016/j.jadr.2023.100478.Peer-Reviewed Original ResearchCitationsAltmetricConcepts
2022
Delayed, Progressive Multivessel Occlusion After Resection of a Recurrent Glioma
Tanglay O, Dadario N, Young I, Yeung J, Teo C, Sughrue M, Yeung J. Delayed, Progressive Multivessel Occlusion After Resection of a Recurrent Glioma. Cureus 2022, 14: e33019. PMID: 36721529, PMCID: PMC9879796, DOI: 10.7759/cureus.33019.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMagnetic resonance imagingCerebral artery infarctionArtery infarctionGlioma resectionGlioblastoma multiformeMiddle cerebral artery infarctionPreoperative magnetic resonance imagingCommon primary brain tumorPosterior cerebral artery infarctionAggressive cytoreductive surgeryAggressive natural historyMiddle cerebral arteryPrimary brain tumorsMost clinical researchMultivessel occlusionCytoreductive surgeryAdjuvant radiochemotherapyMedian survivalNeurologic declineOverall survivalTotal resectionVascular etiologyCerebral arteryPatient outcomesClinical guidanceNCOG-46. PERSONALIZED, PARCEL-GUIDED RTMS FOR NEURO-REHABILITATION AFTER TUMOR NEUROSURGERY: SAFETY AND PROOF OF CONCEPT
Yeung J, Tang J, Holle J, Teo C, Sughrue M. NCOG-46. PERSONALIZED, PARCEL-GUIDED RTMS FOR NEURO-REHABILITATION AFTER TUMOR NEUROSURGERY: SAFETY AND PROOF OF CONCEPT. Neuro-Oncology 2022, 24: vii207-vii208. DOI: 10.1093/neuonc/noac209.797.Peer-Reviewed Original ResearchConceptsRepetitive transcranial magnetic stimulationUpper Extremity Function ScaleLower extremity functional scaleRTMS treatmentBeck Depression InventoryNeurological disordersDepression InventoryNeuropsychiatric disordersNeuro-rehabilitationPost-operative neurological deficitsTranscranial magnetic stimulationQuality of lifeNon-significant trendMultiple cortical targetsFunctional connectivity approachNon-invasive toolEuroQol qualityNeuropsychiatric questionnaireTumor neurosurgeryNeurological deficitsRetrospective reviewPineal cystsPrimary tumorSurgical removalTumor resectionImproving quality of life post-tumor craniotomy using personalized, parcel-guided TMS: safety and proof of concept
Tang S, Holle J, Lesslar O, Teo C, Sughrue M, Yeung J. Improving quality of life post-tumor craniotomy using personalized, parcel-guided TMS: safety and proof of concept. Journal Of Neuro-Oncology 2022, 160: 413-422. PMID: 36308593, DOI: 10.1007/s11060-022-04160-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRepetitive transcranial magnetic stimulationNeuro-cognitive dysfunctionRTMS treatmentBeck Depression InventoryFunctional deficitsNeurological disordersDepression InventoryPost-operative depressionTranscranial magnetic stimulationNeuro-cognitive deficitsNeuro-cognitive functionsMultiple cortical targetsFunctional connectivity approachNon-invasive toolEuroQol qualityNeuropsychiatric questionnaireResultsNine patientsAdverse eventsRetrospective reviewSurgical removalTMS treatmentCortical targetsShort-term memory difficultiesBrain tumorsDepressive symptoms
Academic Achievements & Community Involvement
activity American Association of Neurological Surgeons
CommitteesCommittee MemberDetailsYoung Neurosurgeons Committee08/16/2016 - 01/01/2021honor AANS Tumor Section Skull Base Research Award
National AwardAmerican Association of Neurological SurgeonsDetails04/15/2019United Stateshonor Dennis D. Spencer Academic Achievement Award
Yale School of Medicine AwardDetails06/15/2017United Stateshonor 2017-2018 AANS/CNS Section on Tumors Research Fellowship Grant
National AwardNeurosurgery Research and Education FoundationDetails02/28/2017United Statesactivity Yale School of Medicine
CommitteesCommittee MemberDetailsGraduate Medical Education2013 - 2017
Clinical Care
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Clinical Specialties
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Board Certifications
Neurological Surgery
- Certification Organization
- AB of Neurological Surgery
- Original Certification Date
- 2024
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News
- May 06, 2024
Study Uncovers at Least One Cause of Roadblocks to Cancer Immunotherapy
- November 28, 2022
Jacky Yeung, MD, Receives Grant from American Brain Tumor Foundation for Meningioma Research
- April 23, 2020
New Analysis Reveals Immune Composition of Some Pituitary Tumors
- February 26, 2017
Dr. Jacky Yeung Awarded NREF Tumor Research Fellowship
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