2024
Deletion of the transcription factor EBF1 in perivascular stroma disrupts skeletal homeostasis and precipitates premature aging of the marrow microenvironment
Nelson T, Tommasini S, Fretz J. Deletion of the transcription factor EBF1 in perivascular stroma disrupts skeletal homeostasis and precipitates premature aging of the marrow microenvironment. Bone 2024, 187: 117198. PMID: 39002837, PMCID: PMC11410106, DOI: 10.1016/j.bone.2024.117198.Peer-Reviewed Original ResearchEarly B cell factor 1Disrupt cytokine signallingDisrupt BMP signalingTranscription factor early B cell factor 1B cell factor 1Mesenchymal lineagesGlucocorticoid receptor expressionImpaired osteogenic differentiationLineages in vitroTranscription factorsEBF1 deletionsProgenitor mobilizationMyeloid skewingImpaired fracture repairCytokine signalingSmad1 phosphorylationAge-dependent lossBMP signalingReceptor expressionMarrow microenvironmentAdipogenic lineages in vitroHematopoietic nicheMultiple lineagesBone marrowB cells
2019
Early B Cell Factor 1 (EBF1) Regulates Glomerular Development by Controlling Mesangial Maturation and Consequently COX-2 Expression
Nelson T, Velazquez H, Troiano N, Fretz JA. Early B Cell Factor 1 (EBF1) Regulates Glomerular Development by Controlling Mesangial Maturation and Consequently COX-2 Expression. Journal Of The American Society Of Nephrology 2019, 30: 1559-1572. PMID: 31405952, PMCID: PMC6727263, DOI: 10.1681/asn.2018070699.Peer-Reviewed Original ResearchConceptsCOX-2 expressionEarly B-cell factor 1COX-2Peripheral glomeruliProximal tubular massLineage cellsB cell factor 1Cell factor 1Factor 1Transcription factor early B cell factor 1Glomerular developmentCalcineurin/NFATRenal insufficiencyCell typesGlomerular cell typesGlomerular mesangiumHypoplastic kidneyTubular massFl/Knockout miceMetanephric developmentNFATc1 activationImpaired maturationMiceGlomeruli
2013
Early B-cell factor 1 is an essential transcription factor for postnatal glomerular maturation
Fretz JA, Nelson T, Velazquez H, Xi Y, Moeckel GW, Horowitz MC. Early B-cell factor 1 is an essential transcription factor for postnatal glomerular maturation. Kidney International 2013, 85: 1091-1102. PMID: 24172684, PMCID: PMC4006322, DOI: 10.1038/ki.2013.433.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAlbuminuriaAnimalsBlood Urea NitrogenCell DifferentiationCells, CulturedGene Expression Regulation, DevelopmentalGenotypeGlomerular Filtration RateKidney GlomerulusMice, 129 StrainMice, Inbred C57BLMice, KnockoutOrganogenesisPhenotypePodocytesSignal TransductionTime FactorsTrans-ActivatorsVascular Endothelial Growth Factor AConceptsEarly B-cell factor 1B cell factor 1Transcription factorsNovel roleTranscription factor early B cell factor 1Expression of Ebf1Essential transcription factorFactor 1Podocyte maturationMesenchymal progenitorsB cell maturationProper maturationBlood urea nitrogen levelsElevated blood urea nitrogen levelsWild-type control miceGlomerular filtration rateVascular endothelial growth factor AGlomerular maturationUrea nitrogen levelsGrowth factor ARenal developmentEBF1Factor AGlomerular developmentNephron maturation