2022
Structures of the CcmABCD heme release complex at multiple states
Li J, Zheng W, Gu M, Han L, Luo Y, Yu K, Sun M, Zong Y, Ma X, Liu B, Lowder EP, Mendez DL, Kranz RG, Zhang K, Zhu J. Structures of the CcmABCD heme release complex at multiple states. Nature Communications 2022, 13: 6422. PMID: 36307425, PMCID: PMC9616876, DOI: 10.1038/s41467-022-34136-5.Peer-Reviewed Original ResearchConceptsHigh-resolution cryo-EM structuresResolution cryo-EM structureABC transporter complexAttachment of hemeCryo-EM structureLarge membrane complexesHeme-binding siteATP-binding siteATP-dependent releaseTransfer of hemeC-type cytochromesHeme chaperoneHeme traffickingCytochrome c proteinMembrane proteinsHeme transferTransporter complexMembrane complexATP hydrolysisStructural basisC proteinAMP-PNPFunctional studiesHeme releaseUnbound form
2012
Mechanistic Insights into Regulated Cargo Binding by ACAP1 Protein*
Bai M, Pang X, Lou J, Zhou Q, Zhang K, Ma J, Li J, Sun F, Hsu VW. Mechanistic Insights into Regulated Cargo Binding by ACAP1 Protein*. Journal Of Biological Chemistry 2012, 287: 28675-28685. PMID: 22645133, PMCID: PMC3436524, DOI: 10.1074/jbc.m112.378810.Peer-Reviewed Original ResearchConceptsGTPase-activating proteinsCargo bindingIntegrin recyclingRegulated transportArf6 GTPase-activating ProteinsADP-ribosylation factor (ARF) familyVesicular transport pathwaysMechanistic insightsEndocytic recyclingCoat complexSmall GTPasesCytoplasmic domainCoat componentsFurther mechanistic insightsProtein cargoFactor familyACAP1Functional studiesIntegrin β1Critical sequencesPhosphorylationBindingTransport pathwaysProteinCargo