Adenosine mediates IL-13–induced inflammation and remodeling in the lung and interacts in an IL-13–adenosine amplification pathway
Blackburn MR, Lee CG, Young HW, Zhu Z, Chunn JL, Kang MJ, Banerjee SK, Elias JA. Adenosine mediates IL-13–induced inflammation and remodeling in the lung and interacts in an IL-13–adenosine amplification pathway. Journal Of Clinical Investigation 2003, 112: 332-344. PMID: 12897202, PMCID: PMC166289, DOI: 10.1172/jci16815.Peer-Reviewed Original ResearchConceptsIL-13-induced inflammationIL-13Adenosine receptorsAdenosine accumulationIL-13-induced tissue responsesADA enzyme therapyIL-13 overexpressionTh2-mediated disordersIL-13-induced increaseAmplification pathwayAdenosine deaminase activityLevels of adenosineA2A adenosine receptorsAlveolar destructionRespiratory failureMurine lungEnzyme therapyADA activityRemodeling responseImportant mediatorInflammationLungReceptorsProgressive increaseTissue responseTransgenic modeling of interleukin-13 in the lung.
Elias J, Zheng T, Lee C, Homer R, Chen Q, Ma B, Blackburn M, Zhu Z. Transgenic modeling of interleukin-13 in the lung. CHEST Journal 2003, 123: 339s-45s. PMID: 12628967, DOI: 10.1378/chest.123.3_suppl.339s-a.Peer-Reviewed Original ResearchConceptsIL-13Transforming growth factor-beta(1Vascular endothelial growth factorChemokine receptor 2Endothelial growth factorRegulation of inflammationOverexpressing transgenic miceMurine airwaysAdenosine accumulationAsthma pathogenesisReceptor 2Interleukin-13Transgenic miceIL-11Growth factorGenetic targetsTransgenic modelsLungPhenotypic alterationsRegulate aspectsAdenosine