Inflammasome Priming Mediated via Toll-Like Receptors 2 and 4, Induces Th1-Like Regulatory T Cells in De Novo Autoimmune Hepatitis
Arterbery AS, Yao J, Ling A, Avitzur Y, Martinez M, Lobritto S, Deng Y, Geliang G, Mehta S, Wang G, Knight J, Ekong UD. Inflammasome Priming Mediated via Toll-Like Receptors 2 and 4, Induces Th1-Like Regulatory T Cells in De Novo Autoimmune Hepatitis. Frontiers In Immunology 2018, 9: 1612. PMID: 30072988, PMCID: PMC6060440, DOI: 10.3389/fimmu.2018.01612.Peer-Reviewed Original ResearchToll-like receptor 2Monocytes/macrophagesAutoimmune hepatitisReceptor 2De novo autoimmune hepatitisRegulatory T cell phenotypeTumor necrosis factor αLate allograft dysfunctionLiver transplant subjectsNormal allograft functionNovo autoimmune hepatitisRegulatory T cellsLiver of patientsAdaptive immune mechanismsIFN-γ productionPro-inflammatory cytokinesT-cell phenotypeNecrosis factor αInflammatory signaling pathwaysAllograft dysfunctionAllograft functionDysfunctional TregsSpecific innateTransplant subjectsLiver transplantation