Management of infants born with severe neonatal alloimmune thrombocytopenia: the role of platelet transfusions and intravenous immunoglobulin
Bakchoul T, Bassler D, Heckmann M, Thiele T, Kiefel V, Gross I, Arnold DM, DiTomasso J, Smith JW, Paes B, Greinacher A. Management of infants born with severe neonatal alloimmune thrombocytopenia: the role of platelet transfusions and intravenous immunoglobulin. Transfusion 2013, 54: 640-645. PMID: 23869512, DOI: 10.1111/trf.12336.Peer-Reviewed Original ResearchConceptsNeonatal alloimmune thrombocytopeniaSevere neonatal alloimmune thrombocytopeniaRandom donor plateletsPosttransfusion PLT countsIntravenous immunoglobulinPLT countPLT transfusionsPLT transfusion requirementsFirst-line treatmentLow PLT countHPA-1a alloantibodiesMajor bleedingTransfusion requirementsSevere complicationsCerebral hemorrhageCompatible plateletsIntracranial hemorrhageAlloimmune thrombocytopeniaFetomaternal incompatibilityTransfusionAffected newbornsNewbornsStudy designPlateletsHemorrhage