Transforming Growth Factor- Signaling in Normal and Malignant Hematopoiesis
Isufi I, Seetharam M, Zhou L, Sohal D, Opalinska J, Pahanish P, Verma A. Transforming Growth Factor- Signaling in Normal and Malignant Hematopoiesis. Journal Of Interferon & Cytokine Research 2007, 27: 543-552. PMID: 17651015, DOI: 10.1089/jir.2007.0009.Peer-Reviewed Original ResearchConceptsIntracellular TGF-beta signalingFuture therapeutic interventionsImportant physiologic regulatorTGF-beta receptorsTGF-beta signalingPremalignant stateLymphoid neoplasmsSmall molecule inhibitorsMyeloid cellsTGF receptorTherapeutic interventionsTumor growthHematopoietic stem cellsPhysiologic regulatorTumor microenvironmentGrowth factorGrowth factor signalingMolecule inhibitorsQuiescent hematopoietic stem cellsStem cellsFactor signalingReceptorsCell growthLate progenitorsMalignant hematopoiesis