2024
Eye Drop with Fas-Blocking Peptide Attenuates Age-Related Macular Degeneration
Yi Y, Pyun S, Kim C, Yun G, Kang E, Heo S, Ullah I, Lee S. Eye Drop with Fas-Blocking Peptide Attenuates Age-Related Macular Degeneration. Cells 2024, 13: 548. PMID: 38534392, PMCID: PMC10969560, DOI: 10.3390/cells13060548.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationDry age-related macular degenerationEye dropsMacular degenerationRetinal degenerationProgression of age-related macular degenerationRetinal degeneration mouse modelEye drop administrationRetinal degeneration modelRetinal cell deathExpression of inflammatory cytokinesLack of effective treatmentsRetinal thicknessAMD progressionIntravitreal administrationDrop administrationInflammatory cytokinesMouse modelEffective treatmentTranslational prospectsRabbit modelTherapeutic potentialFas-mediated apoptosisRetinal regionsSignificant health concernSystemic Treatment with Fas-Blocking Peptide Attenuates Apoptosis in Brain Ischemia
Chung S, Yi Y, Ullah I, Chung K, Park S, Lim J, Kim C, Pyun S, Kim M, Kim D, Lee M, Rhim T, Lee S. Systemic Treatment with Fas-Blocking Peptide Attenuates Apoptosis in Brain Ischemia. International Journal Of Molecular Sciences 2024, 25: 661. PMID: 38203830, PMCID: PMC10780202, DOI: 10.3390/ijms25010661.Peer-Reviewed Original ResearchConceptsBlood-brain barrierNeuronal cell deathCentral nervous systemBrain ischemiaIschemic strokeSystemic administrationLeptin receptor-deficient db/db miceDb/db miceLeptin peptideCerebral ischemic strokeCell deathInfarct volumeNeuronal injurySystemic treatmentDb miceBBB penetrationIschemic regionNervous systemNeurological disordersTherapeutic potentialSystemic deliveryIschemiaTherapeutic drugsInfarction regionAdministration
2020
Nose-to-Brain Delivery of Cancer-Targeting Paclitaxel-Loaded Nanoparticles Potentiates Antitumor Effects in Malignant Glioblastoma
Ullah I, Chung K, Bae S, Li Y, Kim C, Choi B, Nam HY, Kim SH, Yun CO, Lee KY, Kumar P, Lee SK. Nose-to-Brain Delivery of Cancer-Targeting Paclitaxel-Loaded Nanoparticles Potentiates Antitumor Effects in Malignant Glioblastoma. Molecular Pharmaceutics 2020, 17: 1193-1204. PMID: 31944768, DOI: 10.1021/acs.molpharmaceut.9b01215.Peer-Reviewed Original ResearchConceptsGlioblastoma multiformeBrain deliveryPoor drug distributionNormal brain cellsCancer cell proliferationCurative treatmentTumor burdenIntranasal inoculationTumor recurrenceAggressive tumorsEnhanced anticancer effectTumor regrowthTherapeutic evidenceTumor remnantsGBM therapyAntitumor effectsBrain cellsTherapeutic efficacyMalignant glioblastomaAnticancer effectsCell proliferationCancer-specific deliveryDrug distributionChemotherapyPaclitaxel