Intranasal delivery of siRNA targeting NR2B attenuates cancer-associated neuropathic pain
Chung K, Ko H, Yi Y, Chung S, Lim J, Park S, Pyun S, Ullah I, Lee J, Kaang B, Lee S. Intranasal delivery of siRNA targeting NR2B attenuates cancer-associated neuropathic pain. Journal Of Pharmaceutical Investigation 2024, 54: 483-495. DOI: 10.1007/s40005-024-00667-w.Peer-Reviewed Original ResearchRo25-6981Pain signalsNR2B expressionMurine modelElectronic von Frey apparatusPhosphorylated extracellular signal-regulated kinaseMechanical withdrawal thresholdCancer-induced painLeft hind pawCancer-associated painCancer cell implantationEvaluate pain reductionBlock pain signalsAdministration of siRNAExtracellular signal-regulated kinaseSignal-regulated kinaseB16F10 melanoma cellsNeuropathic painPain modelWithdrawal thresholdPain reductionMelanoma modelIntranasal deliverySubunit NR2BC57BL/6 mice