2024
Blocking Fas-signaling in adipocytes and hepatocytes prevents obesity-associated inflammation, insulin resistance, and hepatosteatosis
Bae S, Ullah I, Beloor J, Lim J, Chung K, Yi Y, Kang E, Yun G, Rhim T, Lee S. Blocking Fas-signaling in adipocytes and hepatocytes prevents obesity-associated inflammation, insulin resistance, and hepatosteatosis. Journal Of Industrial And Engineering Chemistry 2024, 135: 434-443. DOI: 10.1016/j.jiec.2024.01.055.Peer-Reviewed Original ResearchFas signalingObese mouse modelInhibit Fas signalingFas-mediated apoptosisObesity-associated inflammationFas-signalingInsulin resistanceAdipose tissueMouse modelHepatic steatosisMetabolic dysfunctionSystemic free fatty acidsPro-inflammatory cytokine secretionReduced apoptosisApoptosisFatty acidsReversible inflammationSystemic deliveryCytokine secretionLiver functionInflammatory pathwaysFree fatty acidsLiver steatosisInflammationHepatic triglyceride
2016
Silencing CCR2 in Macrophages Alleviates Adipose Tissue Inflammation and the Associated Metabolic Syndrome in Dietary Obese Mice
Kim J, Chung K, Choi C, Beloor J, Ullah I, Kim N, Lee KY, Lee SK, Kumar P. Silencing CCR2 in Macrophages Alleviates Adipose Tissue Inflammation and the Associated Metabolic Syndrome in Dietary Obese Mice. Molecular Therapy - Nucleic Acids 2016, 5: e280. PMID: 26812653, PMCID: PMC5012549, DOI: 10.1038/mtna.2015.51.Peer-Reviewed Original ResearchAdipose tissueHigh-fat diet-induced obesityPeripheral monocytes/macrophagesObesity-related metabolic diseasesAssociated metabolic syndromeAdipose tissue inflammationAdverse metabolic outcomesObesity-associated inflammationDietary obese miceDiet-induced obesityObese adipose tissueSpecific monocyte subsetsHepatic triglyceride productionRecruitment of macrophagesGene knockdown strategyMonocytes/macrophagesTissue-resident macrophagesInsulin sensitivity profileDietary obesityMetabolic syndromeGlucose toleranceMacrophage infiltrationObese miceProinflammatory cytokinesHepatic steatosis