Targeted siRNA delivery to lung epithelia reduces airway inflammation in a mouse model of allergic asthma
Ullah I, Choi H, Choi C, Chung K, Jung J, Yun G, Heo S, Yi Y, Kang E, Kim S, Yoon H, Rhim T, Lee S. Targeted siRNA delivery to lung epithelia reduces airway inflammation in a mouse model of allergic asthma. Biotechnology And Bioprocess Engineering 2024, 29: 97-108. DOI: 10.1007/s12257-024-00027-3.Peer-Reviewed Original ResearchLung epithelial cellsEpithelial cellsAirway inflammationIL-4RAIL-13IL-4Mouse modelMouse model of allergic asthmaModel of allergic asthmaAllergic pulmonary inflammationCultured lung epithelial cellsReduce airway inflammationInterleukin (IL)-4Asthma mouse modelIL-4 receptorMulti-subunit receptorModel in vivoHypersecretion of mucusIL-4 signalingOvalbumin sensitizationTh2 cytokinesPulmonary inflammationAirway hyperresponsivenessAllergic asthmaLung epithelia