About
Titles
Associate Research Scientist
Appointments
Infectious Diseases
Associate Research ScientistPrimary
Other Departments & Organizations
Education & Training
- PhD
- Hanyang University, Bioengineering (2018)
- BS
- Gomal University, Biotechnology (2010)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Irfan Ullah's published research.
Publications Timeline
A big-picture view of Irfan Ullah's research output by year.
Priti Kumar, PhD
Pradeep Uchil, PhD
Walther Mothes, PhD
Changseon Choi, PhD
Erol Fikrig, MD
Wenwei Li
32Publications
739Citations
Publications
2024
Beta Spike-Presenting SARS-CoV-2 Virus-like Particle Vaccine Confers Broad Protection against Other VOCs in Mice
Ullah I, Symmes K, Keita K, Zhu L, Grunst M, Li W, Mothes W, Kumar P, Uchil P. Beta Spike-Presenting SARS-CoV-2 Virus-like Particle Vaccine Confers Broad Protection against Other VOCs in Mice. Vaccines 2024, 12: 1007. PMID: 39340037, PMCID: PMC11435481, DOI: 10.3390/vaccines12091007.Peer-Reviewed Original ResearchAltmetricConceptsImmune responseVirus-like particlesBeta spikesCross-protective immune responsesSARS-CoV-2 immunitySARS-CoV-2Effective immune responseEffective humoral immune responseHumoral immune responseAncestral spikeT cellsVaccination regimenSARS-CoV-2 virus-like particlesVaccine platformMouse modelVariant spike proteinsOmicron spikeBeta variantDisease burdenNon-infectiousReduce virus spreadImmunityVariant spikesFusion glycoproteinSpike proteinBlocking Fas-signaling in adipocytes and hepatocytes prevents obesity-associated inflammation, insulin resistance, and hepatosteatosis
Bae S, Ullah I, Beloor J, Lim J, Chung K, Yi Y, Kang E, Yun G, Rhim T, Lee S. Blocking Fas-signaling in adipocytes and hepatocytes prevents obesity-associated inflammation, insulin resistance, and hepatosteatosis. Journal Of Industrial And Engineering Chemistry 2024, 135: 434-443. DOI: 10.1016/j.jiec.2024.01.055.Peer-Reviewed Original ResearchConceptsFas signalingObese mouse modelInhibit Fas signalingFas-mediated apoptosisObesity-associated inflammationFas-signalingInsulin resistanceAdipose tissueMouse modelHepatic steatosisMetabolic dysfunctionSystemic free fatty acidsPro-inflammatory cytokine secretionReduced apoptosisApoptosisFatty acidsReversible inflammationSystemic deliveryCytokine secretionLiver functionInflammatory pathwaysFree fatty acidsLiver steatosisInflammationHepatic triglycerideProof-of-concept studies with a computationally designed Mpro inhibitor as a synergistic combination regimen alternative to Paxlovid
Papini C, Ullah I, Ranjan A, Zhang S, Wu Q, Spasov K, Zhang C, Mothes W, Crawford J, Lindenbach B, Uchil P, Kumar P, Jorgensen W, Anderson K. Proof-of-concept studies with a computationally designed Mpro inhibitor as a synergistic combination regimen alternative to Paxlovid. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2320713121. PMID: 38621119, PMCID: PMC11046628, DOI: 10.1073/pnas.2320713121.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDirect-acting antiviralsSARS-CoV-2Lack of off-target effectsIn vitro pharmacological profileTreatment of patientsDevelopment of severe symptomsPharmacological propertiesDrug-drug interactionsSARS-CoV-2 infectionProof-of-concept studySARS-CoV-2 M<sup>pro</sup>.Combination regimenImmunocompromised patientsLead compoundsSARS-CoV-2 main proteaseOral doseActive drugTreat infectionsPharmacological profileSARS-CoV-2 MPotential preclinical candidateOff-target effectsPatientsComplete recoveryCapsule formulationEye Drop with Fas-Blocking Peptide Attenuates Age-Related Macular Degeneration
Yi Y, Pyun S, Kim C, Yun G, Kang E, Heo S, Ullah I, Lee S. Eye Drop with Fas-Blocking Peptide Attenuates Age-Related Macular Degeneration. Cells 2024, 13: 548. PMID: 38534392, PMCID: PMC10969560, DOI: 10.3390/cells13060548.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsAge-related macular degenerationDry age-related macular degenerationEye dropsMacular degenerationRetinal degenerationProgression of age-related macular degenerationRetinal degeneration mouse modelEye drop administrationRetinal degeneration modelRetinal cell deathExpression of inflammatory cytokinesLack of effective treatmentsRetinal thicknessAMD progressionIntravitreal administrationDrop administrationInflammatory cytokinesMouse modelEffective treatmentTranslational prospectsRabbit modelTherapeutic potentialFas-mediated apoptosisRetinal regionsSignificant health concernBlocking Fas signaling in adipose tissue ameliorates obesity-associated inflammation, insulin resistance, and hepatosteatosis
Beloor J, Ullah I, Kim J, Choi C, Kim S, Chung K, KR J, Yi Y, Rhim T, Kumar P, Lee S. Blocking Fas signaling in adipose tissue ameliorates obesity-associated inflammation, insulin resistance, and hepatosteatosis. Journal Of Pharmaceutical Investigation 2024, 54: 519-537. DOI: 10.1007/s40005-024-00668-9.Peer-Reviewed Original ResearchAltmetricConceptsFas signalingMatrix-assisted laser desorption/ionization-time of flight spectrometryBlock Fas signalingNon-apoptotic signalsMatrix-assisted laser desorption/ionization-timeNon-apoptotic pathwaysAdipose tissue macrophagesHigh-fat diet-induced obese mouse modelImpaired insulin signalingInsulin resistanceDiet-induced obesity mouse modelDUTP nick end labeling assayRecruitment of adipose tissue macrophagesFas receptorInsulin signalingPeptide polymerizationNick end labeling assayTissue macrophagesAdipocyte apoptosisSuppress production of inflammatory cytokinesTerminal deoxynucleotidyl transferase dUTP nick end labeling assayReal-time PCRDeoxynucleotidyl transferase dUTP nick end labeling assayObese mouse modelGene expressionTargeted siRNA delivery to lung epithelia reduces airway inflammation in a mouse model of allergic asthma
Ullah I, Choi H, Choi C, Chung K, Jung J, Yun G, Heo S, Yi Y, Kang E, Kim S, Yoon H, Rhim T, Lee S. Targeted siRNA delivery to lung epithelia reduces airway inflammation in a mouse model of allergic asthma. Biotechnology And Bioprocess Engineering 2024, 29: 97-108. DOI: 10.1007/s12257-024-00027-3.Peer-Reviewed Original ResearchAltmetricConceptsLung epithelial cellsEpithelial cellsAirway inflammationIL-4RAIL-13IL-4Mouse modelMouse model of allergic asthmaModel of allergic asthmaAllergic pulmonary inflammationCultured lung epithelial cellsReduce airway inflammationInterleukin (IL)-4Asthma mouse modelIL-4 receptorMulti-subunit receptorModel in vivoHypersecretion of mucusIL-4 signalingOvalbumin sensitizationTh2 cytokinesPulmonary inflammationAirway hyperresponsivenessAllergic asthmaLung epitheliaIntranasal Delivery of Anti-Apoptotic siRNA Complexed with Fas-Signaling Blocking Peptides Attenuates Cellular Apoptosis in Brain Ischemia
Chung K, Ullah I, Yi Y, Kang E, Yun G, Heo S, Kim M, Chung S, Park S, Lim J, Lee M, Rhim T, Lee S. Intranasal Delivery of Anti-Apoptotic siRNA Complexed with Fas-Signaling Blocking Peptides Attenuates Cellular Apoptosis in Brain Ischemia. Pharmaceutics 2024, 16: 290. PMID: 38399343, PMCID: PMC10892455, DOI: 10.3390/pharmaceutics16020290.Peer-Reviewed Original ResearchCitationsConceptsExtrinsic apoptosis pathwayIntrinsic apoptosis pathwayApoptosis pathwayNeuronal cell deathRelease of cytochrome c.Cell deathInhibit Fas signalingNona-arginine peptideFas-signalingFas signalingConfocal microscopy analysisMitochondria disruptionMiddle cerebral artery occlusionFas receptorIntrinsic pathwayTargeting BaxCytochrome c.Molecular mechanismsCellular apoptosisLigand signalingBaxBrain ischemiaPathwayTreatment of brain ischemiaSiRNA complexesIntranasal delivery of siRNA targeting NR2B attenuates cancer-associated neuropathic pain
Chung K, Ko H, Yi Y, Chung S, Lim J, Park S, Pyun S, Ullah I, Lee J, Kaang B, Lee S. Intranasal delivery of siRNA targeting NR2B attenuates cancer-associated neuropathic pain. Journal Of Pharmaceutical Investigation 2024, 54: 483-495. DOI: 10.1007/s40005-024-00667-w.Peer-Reviewed Original ResearchAltmetricConceptsRo25-6981Pain signalsNR2B expressionMurine modelElectronic von Frey apparatusPhosphorylated extracellular signal-regulated kinaseMechanical withdrawal thresholdCancer-induced painLeft hind pawCancer-associated painCancer cell implantationEvaluate pain reductionBlock pain signalsAdministration of siRNAExtracellular signal-regulated kinaseSignal-regulated kinaseB16F10 melanoma cellsNeuropathic painPain modelWithdrawal thresholdPain reductionMelanoma modelIntranasal deliverySubunit NR2BC57BL/6 miceBioluminescence imaging reveals enhanced SARS-CoV-2 clearance in mice with combinatorial regimens
Ullah I, Escudie F, Scandale I, Gilani Z, Gendron-Lepage G, Gaudette F, Mowbray C, Fraisse L, Bazin R, Finzi A, Mothes W, Kumar P, Chatelain E, Uchil P. Bioluminescence imaging reveals enhanced SARS-CoV-2 clearance in mice with combinatorial regimens. IScience 2024, 27: 109049. PMID: 38361624, PMCID: PMC10867665, DOI: 10.1016/j.isci.2024.109049.Peer-Reviewed Original ResearchCitationsAltmetricConceptsDirect-acting antiviralsEfficacy of direct-acting antiviralsVirus clearanceSARS-CoV-2Bioluminescence imagingSuppressed viral loadK18-hACE2 miceRapid virus clearanceNeutralizing antibody treatmentSARS-CoV-2 clearanceEvaluate therapeutic efficacyCOVID-19 convalescent plasmaMonotherapy regimensCombinatorial regimensAntibody treatmentViral loadSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Lung pathologyPandemic potentialRespiratory syndrome coronavirus 2Therapeutic arsenalConvalescent plasmaTreatment efficacySyndrome coronavirus 2Systemic Treatment with Fas-Blocking Peptide Attenuates Apoptosis in Brain Ischemia
Chung S, Yi Y, Ullah I, Chung K, Park S, Lim J, Kim C, Pyun S, Kim M, Kim D, Lee M, Rhim T, Lee S. Systemic Treatment with Fas-Blocking Peptide Attenuates Apoptosis in Brain Ischemia. International Journal Of Molecular Sciences 2024, 25: 661. PMID: 38203830, PMCID: PMC10780202, DOI: 10.3390/ijms25010661.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBlood-brain barrierNeuronal cell deathCentral nervous systemBrain ischemiaIschemic strokeSystemic administrationLeptin receptor-deficient db/db miceDb/db miceLeptin peptideCerebral ischemic strokeCell deathInfarct volumeNeuronal injurySystemic treatmentDb miceBBB penetrationIschemic regionNervous systemNeurological disordersTherapeutic potentialSystemic deliveryIschemiaTherapeutic drugsInfarction regionAdministration
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