Featured Publications
Sex differences in outcomes after coronary artery bypass grafting: a pooled analysis of individual patient data
Gaudino M, Di Franco A, Alexander JH, Bakaeen F, Egorova N, Kurlansky P, Boening A, Chikwe J, Demetres M, Devereaux PJ, Diegeler A, Dimagli A, Flather M, Hameed I, Lamy A, Lawton JS, Reents W, Robinson NB, Audisio K, Rahouma M, Serruys PW, Hara H, Taggart DP, Girardi LN, Fremes SE, Benedetto U. Sex differences in outcomes after coronary artery bypass grafting: a pooled analysis of individual patient data. European Heart Journal 2021, 43: 18-28. PMID: 34338767, PMCID: PMC8851663, DOI: 10.1093/eurheartj/ehab504.Peer-Reviewed Original ResearchConceptsCoronary artery bypassIndividual patient dataMyocardial infarctionArtery bypassCause mortalityWorse outcomesMultiple arterial graftingPatient dataOff-pump surgeryOutcomes of womenCABG trialBaseline characteristicsPatients 75Secondary outcomesPrimary outcomeArterial graftingCox regressionPooled analysisSurgical techniqueHigh riskHigh incidenceSimilar mortalitySystematic reviewRisk adjustmentMortality
2023
Mild aortic insufficiency following transcatheter aortic valve replacement: A systematic review and meta‐analysis
Hameed I, Ahmed A, Kumar A, Li E, Candelario K, Khan S, Kannan A, Latif N, Amabile A, Geirsson A, Williams M. Mild aortic insufficiency following transcatheter aortic valve replacement: A systematic review and meta‐analysis. Catheterization And Cardiovascular Interventions 2023, 102: 166-175. PMID: 37172208, DOI: 10.1002/ccd.30674.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementMild aortic insufficiencyAortic insufficiencyAortic valve replacementPooled incidenceMidterm mortalityValve replacementIncidence of AIModerate-severe aortic insufficiencyHartung-Knapp adjustmentPooled incidence rateLong-term outcomesLonger life expectancyAI incidenceTAVR volumeSecondary outcomesPrimary outcomeYounger patientsFemale patientsMean agePooled analysisIncidence rateTAVR valvePatientsSystematic reviewA robotic-assisted approach to sliding plasty, neochordoplasty, and annuloplasty in a technically complex mitral valve repair.
Amabile A, LaLonde M, Komlo C, Hameed I, Weininger G, Agrawal A, Krane M, Geirsson A. A robotic-assisted approach to sliding plasty, neochordoplasty, and annuloplasty in a technically complex mitral valve repair. Multimedia Manual Of Cardio-Thoracic Surgery 2023, 2023 PMID: 36701207, DOI: 10.1510/mmcts.2022.057.Peer-Reviewed Original Research
2020
Long-Term Results of the RAPCO Trials
Buxton B, Hayward P, Raman J, Moten S, Rosalion A, Gordon I, Seevanayagam S, Matalanis G, Benedetto U, Gaudino M, Hare D, Gaer J, Negri J, Komeda M, Bellomo R, Doolan L, McNicol L, Brennan J, Chan R, Clark D, Dick R, Dortimer A, Ecclestone D, Farouque O, Fernando D, Horrigan M, Jackson A, Oliver L, Mehta N, Nadurata V, Nadarajah N, Proimos G, Rowe M, Sia B, Webb C, Anaveker N, Barlis P, Calafiore P, Chan B, Cotroneo J, Johns J, Jones E, Kertes P, O’Donnell D, Sylviris S, Tonkin A, Fabini R, Kearney L, Lim R, Molan M, Smith G, Wellman C, Eng J, Hameed I, Shaw M, Gerbo S. Long-Term Results of the RAPCO Trials. Circulation 2020, 142: 1330-1338. PMID: 33017209, DOI: 10.1161/circulationaha.119.045427.Peer-Reviewed Original ResearchConceptsRight internal thoracic arteryFree right internal thoracic arteryRadial arteryPatient survival estimatesSaphenous veinYears of ageInternal thoracic artery graftsSurvival estimatesFree RITA graftThoracic artery graftsCoprimary end pointsCoronary bypass surgeryInternal thoracic arteryLong-term mortalityLong-term patencyCoronary targetsRA armRITA graftArtery graftBypass surgeryGraft failureRA groupPrimary outcomeThoracic arterySV graftsRobustness of the Comparative Observational Evidence Supporting Class I and II Cardiac Surgery Procedures
Gaudino M, Hameed I, Robinson NB, Naik A, Weidenmann V, Ruan Y, Tam D, Girardi LN, Fremes S. Robustness of the Comparative Observational Evidence Supporting Class I and II Cardiac Surgery Procedures. Journal Of The American Heart Association 2020, 9: e016964. PMID: 32815427, PMCID: PMC7660761, DOI: 10.1161/jaha.120.016964.Peer-Reviewed Original ResearchConceptsBilateral internal thoracic arteryValve-sparing root replacementSingle internal thoracic arteryInternal thoracic arteryThoracic arteryBentall procedureRoot replacementMV repairObservational studyClass IEffect estimatesCardiac surgery proceduresImproved clinical outcomesMitral valve repairUnmeasured confoundingEffect sizeObserved effect estimatesMV replacementSurgery guidelinesClinical outcomesValve repairRisk ratioArterySurgery proceduresObserved associationsAssociation of Radial Artery Graft vs Saphenous Vein Graft With Long-term Cardiovascular Outcomes Among Patients Undergoing Coronary Artery Bypass Grafting
Gaudino M, Benedetto U, Fremes S, Ballman K, Biondi-Zoccai G, Sedrakyan A, Nasso G, Raman J, Buxton B, Hayward PA, Moat N, Collins P, Webb C, Peric M, Petrovic I, Yoo KJ, Hameed I, Di Franco A, Moscarelli M, Speziale G, Puskas JD, Girardi LN, Hare DL, Taggart DP. Association of Radial Artery Graft vs Saphenous Vein Graft With Long-term Cardiovascular Outcomes Among Patients Undergoing Coronary Artery Bypass Grafting. JAMA 2020, 324: 179-187. PMID: 32662861, PMCID: PMC7361649, DOI: 10.1001/jama.2020.8228.Peer-Reviewed Original ResearchConceptsCoronary artery bypassSaphenous vein graftsComposite of deathRadial artery graftArtery bypassVein graftsRadial arteryMyocardial infarctionArtery graftCardiovascular outcomesClinical outcomesSaphenous veinLong-term cardiovascular outcomesPatient-level pooled analysisCoronary Artery Bypass GraftingArtery Bypass GraftingIndividual participant dataBypass GraftingAdult patientsComposite outcomeSecondary outcomesPrimary outcomeRandomized trialsPooled analysisObservational studySpinal cord injury after open and endovascular repair of descending thoracic and thoracoabdominal aortic aneurysms: A meta-analysis
Gaudino M, Khan FM, Rahouma M, Naik A, Hameed I, Spadaccio C, Robinson NB, Ruan Y, Demetres M, Oakley CT, Gambardella I, Iannacone EM, Lau C, Girardi LN. Spinal cord injury after open and endovascular repair of descending thoracic and thoracoabdominal aortic aneurysms: A meta-analysis. Journal Of Thoracic And Cardiovascular Surgery 2020, 163: 552-564. PMID: 32561196, DOI: 10.1016/j.jtcvs.2020.04.126.Peer-Reviewed Original ResearchConceptsThoracoabdominal aortic aneurysmsPooled rateTAAA repairOperative mortalityEndovascular repairAneurysm repairAortic aneurysmSpinal cord injury ratesGeneric inverse variance methodCrawford extent ILong-term mortalityEndovascular aneurysm repairSpinal cord injuryInverse variance methodDrain-related complicationsSystematic literature searchPostoperative strokeLate mortalitySecondary outcomesOpen repairPrimary outcomeRelated complicationsThoracic aneurysmCord injuryInjury ratesEffect of Concomitant Coronary Artery Bypass Grafting on Outcomes of Ascending Aorta Replacement
Robinson NB, Hameed I, Naik A, Ishtiaq MF, Rahouma M, Girardi LN, Gaudino M. Effect of Concomitant Coronary Artery Bypass Grafting on Outcomes of Ascending Aorta Replacement. The Annals Of Thoracic Surgery 2020, 110: 2041-2046. PMID: 32343949, PMCID: PMC7799918, DOI: 10.1016/j.athoracsur.2020.03.070.Peer-Reviewed Original ResearchConceptsMajor adverse eventsAorta replacementOperative mortalityConcomitant CABGRisk of MAEsConcomitant coronary artery bypassCoronary artery bypass graftEnd pointConcomitant coronary revascularizationPreoperative pulmonary dysfunctionPrimary end pointSecondary end pointsCoronary artery bypassPerioperative myocardial infarctionArtery bypass graftOnly independent predictorHigh-volume centersAscending Aorta ReplacementCABG groupArtery bypassCoronary revascularizationPulmonary dysfunctionUnadjusted incidenceAdverse eventsPostoperative outcomesRisk of Metachronous Colorectal Neoplasm after a Segmental Colectomy in Lynch Syndrome Patients According to Mismatch Repair Gene Status
Quezada-Diaz FF, Hameed I, von Mueffling A, Salo-Mullen EE, Catalano A, Smith JJ, Weiser MR, Garcia-Aguilar J, Stadler ZK, Guillem JG. Risk of Metachronous Colorectal Neoplasm after a Segmental Colectomy in Lynch Syndrome Patients According to Mismatch Repair Gene Status. Journal Of The American College Of Surgeons 2020, 230: 669-675. PMID: 32007537, PMCID: PMC7104918, DOI: 10.1016/j.jamcollsurg.2020.01.005.Peer-Reviewed Original ResearchConceptsLP/P variantsMetachronous colorectal cancerColorectal cancerTotal colectomySegmental resectionSegmental colectomyMMR genesLS patientsLynch syndromeMetachronous colorectal neoplasmsMismatch repair gene statusPrimary end pointRetrospective cohort studyMMR germline mutationsLynch syndrome patientsQuality of lifeMismatch repair genesCRC overallCRC ratesEarly colectomyIndex resectionMedian followMSH2 carriersCRC incidenceCohort studyRobotic Right Hemicolectomy With Complete Mesocolic Excision and D3 Lymph Node Dissection.
Hameed I, Aggarwal P, Weiser MR. Robotic Right Hemicolectomy With Complete Mesocolic Excision and D3 Lymph Node Dissection. Diseases Of The Colon & Rectum 2020, 63: 115. PMID: 31804274, DOI: 10.1097/dcr.0000000000001513.Peer-Reviewed Original Research
2019
Impact of left ventricular ejection fraction on the outcomes of open repair of descending thoracic and thoracoabdominal aneurysms
Gambardella I, Gaudino MFL, Rahouma M, Farrington WJ, Khan FM, Hameed I, Lau C, Iannacone E, Girardi LN. Impact of left ventricular ejection fraction on the outcomes of open repair of descending thoracic and thoracoabdominal aneurysms. Journal Of Thoracic And Cardiovascular Surgery 2019, 161: 534-541.e5. PMID: 31924362, DOI: 10.1016/j.jtcvs.2019.11.009.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionDepressed left ventricular ejection fractionVentricular ejection fractionCubic spline analysisOperative mortalityIndependent predictorsAdverse eventsEjection fractionWorse long-term survivalRisk of MAEThoracoabdominal aneurysm repairWorse preoperative profilesMajor adverse eventsSpline analysisLong-term survivalTAAA repairThoracoabdominal aneurysmsOpen repairAneurysm repairThoracic aneurysmCox regressionPreoperative profilesMortalityMultivariate regressionPatientsAortic Valve Area in Aortic Stenosis A Network Meta-Analysis
Rong LQ, Hameed I, Di Franco A, Rahouma M, Khan FM, Demetres M, Kim J, Weinsaft JW, Devereux RB, Gaudino M. Aortic Valve Area in Aortic Stenosis A Network Meta-Analysis. JACC Cardiovascular Imaging 2019, 13: 634-635. PMID: 31607669, DOI: 10.1016/j.jcmg.2019.08.015.Peer-Reviewed Original ResearchAdolescentAdultAgedAged, 80 and overAortic ValveAortic Valve StenosisChildEchocardiographyEchocardiography, DopplerEchocardiography, Three-DimensionalEchocardiography, TransesophagealFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNetwork Meta-AnalysisPredictive Value of TestsReproducibility of ResultsTomography, X-Ray ComputedYoung AdultThree‐Dimensional Echocardiography for Transcatheter Aortic Valve Replacement Sizing: A Systematic Review and Meta‐Analysis
Rong LQ, Hameed I, Salemi A, Rahouma M, Khan FM, Wijeysundera HC, Angiolillo DJ, Shore‐Lesserson L, Biondi‐Zoccai G, Girardi LN, Fremes SE, Gaudino M. Three‐Dimensional Echocardiography for Transcatheter Aortic Valve Replacement Sizing: A Systematic Review and Meta‐Analysis. Journal Of The American Heart Association 2019, 8: e013463. PMID: 31549579, PMCID: PMC6806040, DOI: 10.1161/jaha.119.013463.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisEchocardiography, Three-DimensionalFemaleHeart Valve ProsthesisHumansMaleMultidetector Computed TomographyObserver VariationPredictive Value of TestsProsthesis DesignRadiographic Image Interpretation, Computer-AssistedReproducibility of ResultsSeverity of Illness IndexTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsTranscatheter aortic valve replacementParavalvular aortic regurgitationAortic regurgitationPrimary outcomeAnnular diameterAnnular perimeterTranscatheter aortic valve replacement sizingSystematic reviewSevere symptomatic aortic stenosisVentricular outflow tract areaBackground Transcatheter aortic valve replacementMean annular diameterOutflow tract areaPre-TAVR planningSymptomatic aortic stenosisAortic valve replacementStandard of careRandom-effects modelSystematic literature searchAnnular areaThree-dimensional echocardiographyContrast exposureRenal dysfunctionAortic stenosisSecondary outcomesCharacteristics and anatomic distribution of early vs late stroke after cardiac surgery
Ivascu NS, Khan FM, Rahouma M, Hameed I, Abouarab A, Segal AZ, Gaudino MFL, Girardi LN. Characteristics and anatomic distribution of early vs late stroke after cardiac surgery. Journal Of Cardiac Surgery 2019, 34: 684-689. PMID: 31212394, DOI: 10.1111/jocs.14121.Peer-Reviewed Original ResearchConceptsLate strokeOperative mortalityCardiac surgeryEarly strokePerioperative strokeOpen cardiac surgeryTime of presentationOpen heart surgeryImpact of strokeWeill Cornell MedicinePerioperative variablesAdult patientsAnterior circulationEmbolic eventsSecondary outcomesCardiopulmonary bypassLikely etiologyAnatomic distributionHeart surgeryRisk factorsAnatomic locationHigh incidencePatientsSurgeryStrokePulmonary artery aneurysms: Preoperative, intraoperative, and postoperative findings
Worku BM, de Angelis P, Wingo ME, Leonard JR, Khan FM, Hameed I, Ruan Y, Gaudino MFL, Girardi LN. Pulmonary artery aneurysms: Preoperative, intraoperative, and postoperative findings. Journal Of Cardiac Surgery 2019, 34: 570-576. PMID: 31090116, DOI: 10.1111/jocs.14070.Peer-Reviewed Original ResearchConceptsPulmonary artery aneurysmLarge pulmonary artery aneurysmAssociated pulmonary hypertensionChronic pulmonary embolismCross-clamp timePulmonary arterial hypertensionCommon clinical findingImprovement of symptomsStandard treatment guidelinesAcceptable risk profileCongenital heart disordersBaseline hypertensionPAA repairPostoperative mortalityArterial hypertensionPulmonary hypertensionPostoperative findingsPulmonary embolismSelect patientsYounger patientsTreatment guidelinesValve proceduresArtery aneurysmSignificant morbidityClinical findings