2021
Financial Associations Between Authors of Commentaries on Randomized Clinical Trials of Invasive Cardiovascular Interventions and Trial Sponsors
Hameed I, Mori M, Ahmed A, Naeem N, Oakley CT, Gaudino M, Geirsson A. Financial Associations Between Authors of Commentaries on Randomized Clinical Trials of Invasive Cardiovascular Interventions and Trial Sponsors. JAMA Internal Medicine 2021, 181: 1662-1665. PMID: 34398175, PMCID: PMC8369423, DOI: 10.1001/jamainternmed.2021.4584.Peer-Reviewed Original ResearchEffects of Experimental Interventions to Improve the Biomedical Peer‐Review Process: A Systematic Review and Meta‐Analysis
Gaudino M, Robinson NB, Di Franco A, Hameed I, Naik A, Demetres M, Girardi LN, Frati G, Fremes SE, Biondi‐Zoccai G. Effects of Experimental Interventions to Improve the Biomedical Peer‐Review Process: A Systematic Review and Meta‐Analysis. Journal Of The American Heart Association 2021, 10: e019903. PMID: 34278828, PMCID: PMC8475712, DOI: 10.1161/jaha.120.019903.Peer-Reviewed Original ResearchMeSH KeywordsBiomedical ResearchEditorial PoliciesHumansNetwork Meta-AnalysisPeer Review, ResearchPeriodicals as TopicQuality ControlRandomized Controlled Trials as TopicTime FactorsConceptsStandardized mean differenceRandomized trialsEffects of interventionsPeer review interventionMean changeMAIN OUTCOMESmall studySystematic reviewMeta-AnalysisMean differenceLonger durationExperimental interventionInterventionIndividual studiesTrialsFurther studiesImproved qualityDurationConclusion ModificationReview qualitySignificant improvementPeer review processBackground qualityCharacteristics of Randomized Clinical Trials in Surgery From 2008 to 2020
Robinson NB, Fremes S, Hameed I, Rahouma M, Weidenmann V, Demetres M, Morsi M, Soletti G, Di Franco A, Zenati MA, Raja SG, Moher D, Bakaeen F, Chikwe J, Bhatt DL, Kurlansky P, Girardi LN, Gaudino M. Characteristics of Randomized Clinical Trials in Surgery From 2008 to 2020. JAMA Network Open 2021, 4: e2114494. PMID: 34190996, PMCID: PMC8246313, DOI: 10.1001/jamanetworkopen.2021.14494.Peer-Reviewed Original ResearchConceptsMost trialsClinical eventsSurgical interventionSurgical RCTsClinical trialsSurgeon experienceMinor clinical eventsMore surgical interventionsReporting biasMajor clinical eventsRandomized clinical trialsRisk of biasMedian fragility indexMedian sample sizeLarge treatment effectsPrimary outcomeTRIAL REGISTRATIONControl armTrial characteristicsSurgical trialsHigh riskSuperiority designConcerns of biasPrimary analysisRCTsAngiographic Patency of Coronary Artery Bypass Conduits: A Network Meta‐Analysis of Randomized Trials
Gaudino M, Hameed I, Robinson NB, Ruan Y, Rahouma M, Naik A, Weidenmann V, Demetres M, Tam D, Hare DL, Girardi LN, Biondi‐Zoccai G, Fremes S. Angiographic Patency of Coronary Artery Bypass Conduits: A Network Meta‐Analysis of Randomized Trials. Journal Of The American Heart Association 2021, 10: e019206. PMID: 33686866, PMCID: PMC8174193, DOI: 10.1161/jaha.120.019206.Peer-Reviewed Original ResearchMeSH KeywordsCoronary AngiographyCoronary Artery BypassCoronary Artery DiseaseHumansMammary ArteriesNetwork Meta-AnalysisRandomized Controlled Trials as TopicSaphenous VeinVascular PatencyConceptsCoronary artery bypass conduitsTouch saphenous veinAngiographic patency ratesRadial arterySaphenous veinPatency ratesGraft occlusionRandomized trialsBypass conduitRight internal thoracic arteryTouch saphenous vein graftsCoronary bypass surgerySaphenous vein graftsGraft occlusion rateInternal thoracic arteryBest conduitNetwork Meta-AnalysisSystematic literature searchGastroepiploic arteryBypass surgeryPrimary outcomeThoracic arteryAngiographic patencyVein graftsOcclusion rate
2020
Overall and Cause-Specific Mortality in Randomized Clinical Trials Comparing Percutaneous Interventions With Coronary Bypass Surgery
Gaudino M, Hameed I, Farkouh ME, Rahouma M, Naik A, Robinson NB, Ruan Y, Demetres M, Biondi-Zoccai G, Angiolillo DJ, Bagiella E, Charlson ME, Benedetto U, Ruel M, Taggart DP, Girardi LN, Bhatt DL, Fremes SE. Overall and Cause-Specific Mortality in Randomized Clinical Trials Comparing Percutaneous Interventions With Coronary Bypass Surgery. JAMA Internal Medicine 2020, 180: 1638-1646. PMID: 33044497, PMCID: PMC7551235, DOI: 10.1001/jamainternmed.2020.4748.Peer-Reviewed Original ResearchMeSH KeywordsCause of DeathCoronary Artery BypassCoronary Artery DiseaseDrug-Eluting StentsFemaleHumansIncidenceMaleMyocardial InfarctionPercutaneous Coronary InterventionRandomized Controlled Trials as TopicRisk FactorsTime FactorsConceptsPercutaneous coronary interventionRandomized clinical trialsCause-specific mortalityCoronary artery diseaseBare metal stentsNoncardiac mortalityCause mortalityCoronary interventionArtery diseaseClinical trialsTrials of PCIEnd pointLeft main diseaseCoronary artery bypassStudy end pointCoronary bypass surgeryData extractionTreatment of patientsCochrane Library databasesPreferred Reporting ItemsRandom-effects modelArtery bypassCardiac mortalityRevascularization TrialBypass surgerySex‐related differences in outcomes after coronary artery bypass surgery—A patient‐level pooled analysis of randomized controlled trials: rationale and study protocol
Gaudino M, Alexander JH, Egorova N, Kurlansky P, Lamy A, Bakaeen F, Hameed I, Di Franco A, Demetres M, Robinson NB, Chikwe J, Lawton JS, Devereaux PJ, Taggart DP, Flather M, Reents W, Boening A, Diegeler A, Girardi LN, Fremes SE, Benedetto U. Sex‐related differences in outcomes after coronary artery bypass surgery—A patient‐level pooled analysis of randomized controlled trials: rationale and study protocol. Journal Of Cardiac Surgery 2020, 35: 2754-2758. PMID: 32720394, DOI: 10.1111/jocs.14903.Peer-Reviewed Original ResearchConceptsSex-related differencesPooled analysisSystematic reviewPatient-level pooled analysisCoronary artery bypass surgeryMultiple arterial graftsArtery bypass surgeryCoronary artery bypassLong-term followSex-related outcomesTreatment effectsPreferred Reporting ItemsSystematic literature searchPeer-reviewed scientific journalsImpact of sexDifferential treatment effectsCABG studiesArtery bypassCause mortalityPrimary endpointBypass surgeryArterial graftsMyocardial infarctionStudy protocolProspective RegisterAssociation of Radial Artery Graft vs Saphenous Vein Graft With Long-term Cardiovascular Outcomes Among Patients Undergoing Coronary Artery Bypass Grafting
Gaudino M, Benedetto U, Fremes S, Ballman K, Biondi-Zoccai G, Sedrakyan A, Nasso G, Raman J, Buxton B, Hayward PA, Moat N, Collins P, Webb C, Peric M, Petrovic I, Yoo KJ, Hameed I, Di Franco A, Moscarelli M, Speziale G, Puskas JD, Girardi LN, Hare DL, Taggart DP. Association of Radial Artery Graft vs Saphenous Vein Graft With Long-term Cardiovascular Outcomes Among Patients Undergoing Coronary Artery Bypass Grafting. JAMA 2020, 324: 179-187. PMID: 32662861, PMCID: PMC7361649, DOI: 10.1001/jama.2020.8228.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery BypassFemaleFollow-Up StudiesHumansIncidenceMaleMyocardial InfarctionPostoperative ComplicationsRadial ArteryRandomized Controlled Trials as TopicReoperationSaphenous VeinTime FactorsTreatment OutcomeConceptsCoronary artery bypassSaphenous vein graftsComposite of deathRadial artery graftArtery bypassVein graftsRadial arteryMyocardial infarctionArtery graftCardiovascular outcomesClinical outcomesSaphenous veinLong-term cardiovascular outcomesPatient-level pooled analysisCoronary Artery Bypass GraftingArtery Bypass GraftingIndividual participant dataBypass GraftingAdult patientsComposite outcomeSecondary outcomesPrimary outcomeRandomized trialsPooled analysisObservational studyCharacteristics of Contemporary Randomized Clinical Trials and Their Association With the Trial Funding Source in Invasive Cardiovascular Interventions
Gaudino M, Hameed I, Rahouma M, Khan FM, Tam DY, Biondi-Zoccai G, Demetres M, Charlson ME, Ruel M, Crea F, Falk V, Girardi LN, Fremes S, Chikwe J. Characteristics of Contemporary Randomized Clinical Trials and Their Association With the Trial Funding Source in Invasive Cardiovascular Interventions. JAMA Internal Medicine 2020, 180: 993-1001. PMID: 32478821, PMCID: PMC7265124, DOI: 10.1001/jamainternmed.2020.1670.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesCosts and Cost AnalysisHumansMyocardial RevascularizationRandomized Controlled Trials as TopicConceptsPrimary end pointInvasive cardiovascular interventionsPrimary outcomeClinical trialsEnd pointCardiovascular interventionsSignificant differencesComposite primary end pointContemporary Randomized Clinical TrialsStructural interventional cardiologyTrial funding sourceCardiac surgical proceduresRandomized clinical trialsNumber of patientsCross-sectional studyExperimental interventionReporting of trialsTreatment effectsMedian sample sizeLarge treatment effectsContemporary RCTsGuideline recommendationsEvidence-based practiceTrial sponsorshipFavorable outcomeResponse of Cardiac Surgery Units to COVID-19: An Internationally-Based Quantitative Survey
Gaudino M, Chikwe J, Hameed I, Robinson NB, Fremes SE, Ruel M. Response of Cardiac Surgery Units to COVID-19: An Internationally-Based Quantitative Survey. Circulation 2020, 142: 300-302. PMID: 32392425, PMCID: PMC7365675, DOI: 10.1161/circulationaha.120.047865.Peer-Reviewed Original ResearchBetacoronavirusCardiac Surgical ProceduresCardiologistsCoronavirus InfectionsCOVID-19Delivery of Health Care, IntegratedHealth Care SurveysHeart DiseasesHost Microbial InteractionsHumansPandemicsPersonnel Staffing and SchedulingPneumonia, ViralPractice Patterns, Physicians'Randomized Controlled Trials as TopicSARS-CoV-2SurgeonsTime-to-TreatmentTreatment OutcomeWorkflow
2019
Systematic Evaluation of the Robustness of the Evidence Supporting Current Guidelines on Myocardial Revascularization Using the Fragility Index
Gaudino M, Hameed I, Biondi-Zoccai G, Tam DY, Gerry S, Rahouma M, Khan FM, Angiolillo DJ, Benedetto U, Taggart DP, Girardi LN, Crea F, Ruel M, Fremes SE. Systematic Evaluation of the Robustness of the Evidence Supporting Current Guidelines on Myocardial Revascularization Using the Fragility Index. Circulation Cardiovascular Quality And Outcomes 2019, 12: e006017. PMID: 31822120, DOI: 10.1161/circoutcomes.119.006017.Peer-Reviewed Original ResearchDisagreement Between Randomized and Observational Evidence on the Use of Bilateral Internal Thoracic Artery Grafting: A Meta‐Analytic Approach
Gaudino M, Rahouma M, Hameed I, Khan FM, Taggart DP, Flather M, Biondi‐Zoccai G, Fremes SE. Disagreement Between Randomized and Observational Evidence on the Use of Bilateral Internal Thoracic Artery Grafting: A Meta‐Analytic Approach. Journal Of The American Heart Association 2019, 8: e014638. PMID: 31752642, PMCID: PMC6912987, DOI: 10.1161/jaha.119.014638.Peer-Reviewed Original ResearchMeSH KeywordsHumansMammary ArteriesObservational Studies as TopicRandomized Controlled Trials as TopicConceptsInternal thoracic arteryObservational studyThoracic arterySurvival dataBilateral Internal Thoracic Artery GraftingBilateral internal thoracic artery groupBilateral internal thoracic arteryCox regression hazardPropensity-matched studyLong-term outcomesMost observational studiesArtery GraftingArtery groupImproved survivalControl armImproved outcomesControl groupSurvival curvesArteryBeneficial effectsMeta-analytic approachSurvivalPatientsExperimental groupOutcomesThe RADial artery International ALliance (RADIAL) extended follow-up study: rationale and study protocol
Gaudino M, Benedetto U, Fremes S, Ballman K, Biondi-Zoccai G, Sedrakyan A, Nasso G, Raman J, Buxton B, Hayward PA, Moat N, Collins P, Webb C, Peric M, Petrovic I, Yoo KJ, Hameed I, Di Franco A, Moscarelli M, Speziale G, Girardi LN, Hare DL, Taggart DP, Investigators R. The RADial artery International ALliance (RADIAL) extended follow-up study: rationale and study protocol. European Journal Of Cardio-Thoracic Surgery 2019, 56: 1025-1030. PMID: 31535147, DOI: 10.1093/ejcts/ezz247.Peer-Reviewed Original ResearchMeSH KeywordsCoronary Artery BypassDatabases, FactualFollow-Up StudiesHumansMeta-Analysis as TopicRadial ArteryRandomized Controlled Trials as TopicSaphenous VeinTreatment OutcomeVascular PatencyConceptsPatency ratesSaphenous veinGood mid-term patency ratesMid-term patency ratesCoronary artery bypass surgeryRadial artery graftArtery bypass surgeryEvent-free survivalSaphenous vein graftsLong-term outcomesImproved patency ratesRA armArtery graftPostoperative yearRepeat revascularizationBypass surgeryCardiac eventsVein graftsClinical correlatesStudy protocolObservational studyRole of RasGraftTrialsSurvival