Featured Publications
Sex differences in outcomes after coronary artery bypass grafting: a pooled analysis of individual patient data
Gaudino M, Di Franco A, Alexander JH, Bakaeen F, Egorova N, Kurlansky P, Boening A, Chikwe J, Demetres M, Devereaux PJ, Diegeler A, Dimagli A, Flather M, Hameed I, Lamy A, Lawton JS, Reents W, Robinson NB, Audisio K, Rahouma M, Serruys PW, Hara H, Taggart DP, Girardi LN, Fremes SE, Benedetto U. Sex differences in outcomes after coronary artery bypass grafting: a pooled analysis of individual patient data. European Heart Journal 2021, 43: 18-28. PMID: 34338767, PMCID: PMC8851663, DOI: 10.1093/eurheartj/ehab504.Peer-Reviewed Original ResearchConceptsCoronary artery bypassIndividual patient dataMyocardial infarctionArtery bypassCause mortalityWorse outcomesMultiple arterial graftingPatient dataOff-pump surgeryOutcomes of womenCABG trialBaseline characteristicsPatients 75Secondary outcomesPrimary outcomeArterial graftingCox regressionPooled analysisSurgical techniqueHigh riskHigh incidenceSimilar mortalitySystematic reviewRisk adjustmentMortality
2023
A Systematic Review of Contemporary Randomized Trials in Cardiothoracic Surgery
Robinson N, Rahouma M, Audisio K, Cancelli G, Demetres M, Soletti G, Hameed I, Girardi L, Ruel M, Fremes S, Gaudino M. A Systematic Review of Contemporary Randomized Trials in Cardiothoracic Surgery. Annals Of Thoracic Surgery Short Reports 2023, 1: 537-541. DOI: 10.1016/j.atssr.2023.05.017.Peer-Reviewed Original ResearchCardiothoracic surgeryMost trialsPrimary outcomePrimary end pointComposite primary outcomeMajor clinical eventsMedian fragility indexEligible trialsRandomized trialsTrial armsClinical eventsContemporary trialsFavorable outcomePatient outcomesTrial characteristicsMedian numberSurgeon experienceResults NinetyGeneral surgeryHigh riskSuperiority designSurgerySystematic reviewEnd pointTrialsMild aortic insufficiency following transcatheter aortic valve replacement: A systematic review and meta‐analysis
Hameed I, Ahmed A, Kumar A, Li E, Candelario K, Khan S, Kannan A, Latif N, Amabile A, Geirsson A, Williams M. Mild aortic insufficiency following transcatheter aortic valve replacement: A systematic review and meta‐analysis. Catheterization And Cardiovascular Interventions 2023, 102: 166-175. PMID: 37172208, DOI: 10.1002/ccd.30674.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementMild aortic insufficiencyAortic insufficiencyAortic valve replacementPooled incidenceMidterm mortalityValve replacementIncidence of AIModerate-severe aortic insufficiencyHartung-Knapp adjustmentPooled incidence rateLong-term outcomesLonger life expectancyAI incidenceTAVR volumeSecondary outcomesPrimary outcomeYounger patientsFemale patientsMean agePooled analysisIncidence rateTAVR valvePatientsSystematic review
2021
Effects of Experimental Interventions to Improve the Biomedical Peer‐Review Process: A Systematic Review and Meta‐Analysis
Gaudino M, Robinson NB, Di Franco A, Hameed I, Naik A, Demetres M, Girardi LN, Frati G, Fremes SE, Biondi‐Zoccai G. Effects of Experimental Interventions to Improve the Biomedical Peer‐Review Process: A Systematic Review and Meta‐Analysis. Journal Of The American Heart Association 2021, 10: e019903. PMID: 34278828, PMCID: PMC8475712, DOI: 10.1161/jaha.120.019903.Peer-Reviewed Original ResearchConceptsStandardized mean differenceRandomized trialsEffects of interventionsPeer review interventionMean changeMAIN OUTCOMESmall studySystematic reviewMeta-AnalysisMean differenceLonger durationExperimental interventionInterventionIndividual studiesTrialsFurther studiesImproved qualityDurationConclusion ModificationReview qualitySignificant improvementPeer review processBackground qualityComparison of SYNTAX score strata effects of percutaneous and surgical revascularization trials: A meta-analysis
Gaudino M, Hameed I, Di Franco A, Naik A, Demetres M, Biondi-Zoccai G, Bangalore S. Comparison of SYNTAX score strata effects of percutaneous and surgical revascularization trials: A meta-analysis. Journal Of Thoracic And Cardiovascular Surgery 2021, 165: 1405-1413.e13. PMID: 34176619, PMCID: PMC8805094, DOI: 10.1016/j.jtcvs.2021.05.036.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionCoronary artery bypassIncidence rate ratiosCoronary interventionArtery bypassCerebrovascular eventsSYNTAX scoreMultivessel diseaseCause mortalityStatistical heterogeneityRate ratioSystematic reviewCardiac Surgery (SYNTAX) scoreSYNTAX score tertilesCochrane Library databasesMain analysisSignificant statistical heterogeneityRandom-effects modelRevascularization TrialScore tertilesSecondary outcomesSurgery scoreRisk stratificationLibrary databasesNonsignificant increase
2020
Sex‐related differences in outcomes after coronary artery bypass surgery—A patient‐level pooled analysis of randomized controlled trials: rationale and study protocol
Gaudino M, Alexander JH, Egorova N, Kurlansky P, Lamy A, Bakaeen F, Hameed I, Di Franco A, Demetres M, Robinson NB, Chikwe J, Lawton JS, Devereaux PJ, Taggart DP, Flather M, Reents W, Boening A, Diegeler A, Girardi LN, Fremes SE, Benedetto U. Sex‐related differences in outcomes after coronary artery bypass surgery—A patient‐level pooled analysis of randomized controlled trials: rationale and study protocol. Journal Of Cardiac Surgery 2020, 35: 2754-2758. PMID: 32720394, DOI: 10.1111/jocs.14903.Peer-Reviewed Original ResearchConceptsSex-related differencesPooled analysisSystematic reviewPatient-level pooled analysisCoronary artery bypass surgeryMultiple arterial graftsArtery bypass surgeryCoronary artery bypassLong-term followSex-related outcomesTreatment effectsPreferred Reporting ItemsSystematic literature searchPeer-reviewed scientific journalsImpact of sexDifferential treatment effectsCABG studiesArtery bypassCause mortalityPrimary endpointBypass surgeryArterial graftsMyocardial infarctionStudy protocolProspective RegisterAn assessment of the quality of current clinical meta-analyses
Hameed I, Demetres M, Tam DY, Rahouma M, Khan FM, Wright DN, Mages K, DeRosa AP, Baltich Nelson B, Pain K, Delgado D, Girardi LN, Fremes SE, Gaudino M. An assessment of the quality of current clinical meta-analyses. BMC Medical Research Methodology 2020, 20: 105. PMID: 32380945, PMCID: PMC7204021, DOI: 10.1186/s12874-020-00999-9.Peer-Reviewed Original ResearchConceptsSystematic reviewPreferred Reporting ItemsElectronic search strategyOverall median scoreMeta-analysis characteristicsCochrane HandbookMethodological qualityBackgroundThe objectiveReporting ItemsConclusionThis studyMeta-AnalysisMedian scoreClinical journalsEarly involvementStrict adherenceScoresMedical librariansInvolvement of librariansInformation specialistsOverall qualityGuidelinesReviewMultiple regressionPRISMAQuality scoresComparison of the effects of hemodialysis and hemodiafiltration on left ventricular hypertrophy in end‐stage renal disease patients: A systematic review and meta‐analysis
Hameed I, Gaudino M, Naik A, Rahouma M, Robinson NB, Ruan Y, Demetres M, Bossola M. Comparison of the effects of hemodialysis and hemodiafiltration on left ventricular hypertrophy in end‐stage renal disease patients: A systematic review and meta‐analysis. Seminars In Dialysis 2020, 33: 120-126. PMID: 32159258, DOI: 10.1111/sdi.12864.Peer-Reviewed Original ResearchConceptsLeft ventricular mass indexEjection fractionMean differenceVentricular hypertrophySubgroup analysisConventional hemodialysisEnd-stage renal disease patientsLonger dialysis durationVentricular mass indexPooled mean differenceRenal disease patientsEffect of hemodialysisLeft ventricular hypertrophySystematic literature searchDialysis durationPrimary outcomeSecondary outcomesMass indexDisease patientsHemodialysisSystematic reviewHemodiafiltrationLowest mean differenceLiterature searchPatients
2019
An Invited Commentary on “Does saphenous vein graft failure even matter? Commentary on: Mid-term and long-term outcomes of endoscopic versus open vein harvesting for coronary artery bypass: A systematic review and meta-analysis” (Int J Surg 2019;72:167–173)
Naik A, Hameed I, Gaudino M. An Invited Commentary on “Does saphenous vein graft failure even matter? Commentary on: Mid-term and long-term outcomes of endoscopic versus open vein harvesting for coronary artery bypass: A systematic review and meta-analysis” (Int J Surg 2019;72:167–173). International Journal Of Surgery 2019, 74: 25-26. PMID: 31862255, DOI: 10.1016/j.ijsu.2019.12.007.Peer-Reviewed Original ResearchThree‐Dimensional Echocardiography for Transcatheter Aortic Valve Replacement Sizing: A Systematic Review and Meta‐Analysis
Rong LQ, Hameed I, Salemi A, Rahouma M, Khan FM, Wijeysundera HC, Angiolillo DJ, Shore‐Lesserson L, Biondi‐Zoccai G, Girardi LN, Fremes SE, Gaudino M. Three‐Dimensional Echocardiography for Transcatheter Aortic Valve Replacement Sizing: A Systematic Review and Meta‐Analysis. Journal Of The American Heart Association 2019, 8: e013463. PMID: 31549579, PMCID: PMC6806040, DOI: 10.1161/jaha.119.013463.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisEchocardiography, Three-DimensionalFemaleHeart Valve ProsthesisHumansMaleMultidetector Computed TomographyObserver VariationPredictive Value of TestsProsthesis DesignRadiographic Image Interpretation, Computer-AssistedReproducibility of ResultsSeverity of Illness IndexTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsTranscatheter aortic valve replacementParavalvular aortic regurgitationAortic regurgitationPrimary outcomeAnnular diameterAnnular perimeterTranscatheter aortic valve replacement sizingSystematic reviewSevere symptomatic aortic stenosisVentricular outflow tract areaBackground Transcatheter aortic valve replacementMean annular diameterOutflow tract areaPre-TAVR planningSymptomatic aortic stenosisAortic valve replacementStandard of careRandom-effects modelSystematic literature searchAnnular areaThree-dimensional echocardiographyContrast exposureRenal dysfunctionAortic stenosisSecondary outcomes