Featured Publications
Sex differences in outcomes after coronary artery bypass grafting: a pooled analysis of individual patient data
Gaudino M, Di Franco A, Alexander JH, Bakaeen F, Egorova N, Kurlansky P, Boening A, Chikwe J, Demetres M, Devereaux PJ, Diegeler A, Dimagli A, Flather M, Hameed I, Lamy A, Lawton JS, Reents W, Robinson NB, Audisio K, Rahouma M, Serruys PW, Hara H, Taggart DP, Girardi LN, Fremes SE, Benedetto U. Sex differences in outcomes after coronary artery bypass grafting: a pooled analysis of individual patient data. European Heart Journal 2021, 43: 18-28. PMID: 34338767, PMCID: PMC8851663, DOI: 10.1093/eurheartj/ehab504.Peer-Reviewed Original ResearchConceptsCoronary artery bypassIndividual patient dataMyocardial infarctionArtery bypassCause mortalityWorse outcomesMultiple arterial graftingPatient dataOff-pump surgeryOutcomes of womenCABG trialBaseline characteristicsPatients 75Secondary outcomesPrimary outcomeArterial graftingCox regressionPooled analysisSurgical techniqueHigh riskHigh incidenceSimilar mortalitySystematic reviewRisk adjustmentMortality
2023
A Systematic Review of Contemporary Randomized Trials in Cardiothoracic Surgery
Robinson N, Rahouma M, Audisio K, Cancelli G, Demetres M, Soletti G, Hameed I, Girardi L, Ruel M, Fremes S, Gaudino M. A Systematic Review of Contemporary Randomized Trials in Cardiothoracic Surgery. Annals Of Thoracic Surgery Short Reports 2023, 1: 537-541. DOI: 10.1016/j.atssr.2023.05.017.Peer-Reviewed Original ResearchCardiothoracic surgeryMost trialsPrimary outcomePrimary end pointComposite primary outcomeMajor clinical eventsMedian fragility indexEligible trialsRandomized trialsTrial armsClinical eventsContemporary trialsFavorable outcomePatient outcomesTrial characteristicsMedian numberSurgeon experienceResults NinetyGeneral surgeryHigh riskSuperiority designSurgerySystematic reviewEnd pointTrialsMild aortic insufficiency following transcatheter aortic valve replacement: A systematic review and meta‐analysis
Hameed I, Ahmed A, Kumar A, Li E, Candelario K, Khan S, Kannan A, Latif N, Amabile A, Geirsson A, Williams M. Mild aortic insufficiency following transcatheter aortic valve replacement: A systematic review and meta‐analysis. Catheterization And Cardiovascular Interventions 2023, 102: 166-175. PMID: 37172208, DOI: 10.1002/ccd.30674.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementMild aortic insufficiencyAortic insufficiencyAortic valve replacementPooled incidenceMidterm mortalityValve replacementIncidence of AIModerate-severe aortic insufficiencyHartung-Knapp adjustmentPooled incidence rateLong-term outcomesLonger life expectancyAI incidenceTAVR volumeSecondary outcomesPrimary outcomeYounger patientsFemale patientsMean agePooled analysisIncidence rateTAVR valvePatientsSystematic review
2021
Characteristics of Randomized Clinical Trials in Surgery From 2008 to 2020
Robinson NB, Fremes S, Hameed I, Rahouma M, Weidenmann V, Demetres M, Morsi M, Soletti G, Di Franco A, Zenati MA, Raja SG, Moher D, Bakaeen F, Chikwe J, Bhatt DL, Kurlansky P, Girardi LN, Gaudino M. Characteristics of Randomized Clinical Trials in Surgery From 2008 to 2020. JAMA Network Open 2021, 4: e2114494. PMID: 34190996, PMCID: PMC8246313, DOI: 10.1001/jamanetworkopen.2021.14494.Peer-Reviewed Original ResearchConceptsMost trialsClinical eventsSurgical interventionSurgical RCTsClinical trialsSurgeon experienceMinor clinical eventsMore surgical interventionsReporting biasMajor clinical eventsRandomized clinical trialsRisk of biasMedian fragility indexMedian sample sizeLarge treatment effectsPrimary outcomeTRIAL REGISTRATIONControl armTrial characteristicsSurgical trialsHigh riskSuperiority designConcerns of biasPrimary analysisRCTsAngiographic Patency of Coronary Artery Bypass Conduits: A Network Meta‐Analysis of Randomized Trials
Gaudino M, Hameed I, Robinson NB, Ruan Y, Rahouma M, Naik A, Weidenmann V, Demetres M, Tam D, Hare DL, Girardi LN, Biondi‐Zoccai G, Fremes S. Angiographic Patency of Coronary Artery Bypass Conduits: A Network Meta‐Analysis of Randomized Trials. Journal Of The American Heart Association 2021, 10: e019206. PMID: 33686866, PMCID: PMC8174193, DOI: 10.1161/jaha.120.019206.Peer-Reviewed Original ResearchConceptsCoronary artery bypass conduitsTouch saphenous veinAngiographic patency ratesRadial arterySaphenous veinPatency ratesGraft occlusionRandomized trialsBypass conduitRight internal thoracic arteryTouch saphenous vein graftsCoronary bypass surgerySaphenous vein graftsGraft occlusion rateInternal thoracic arteryBest conduitNetwork Meta-AnalysisSystematic literature searchGastroepiploic arteryBypass surgeryPrimary outcomeThoracic arteryAngiographic patencyVein graftsOcclusion rate
2020
Long-Term Results of the RAPCO Trials
Buxton B, Hayward P, Raman J, Moten S, Rosalion A, Gordon I, Seevanayagam S, Matalanis G, Benedetto U, Gaudino M, Hare D, Gaer J, Negri J, Komeda M, Bellomo R, Doolan L, McNicol L, Brennan J, Chan R, Clark D, Dick R, Dortimer A, Ecclestone D, Farouque O, Fernando D, Horrigan M, Jackson A, Oliver L, Mehta N, Nadurata V, Nadarajah N, Proimos G, Rowe M, Sia B, Webb C, Anaveker N, Barlis P, Calafiore P, Chan B, Cotroneo J, Johns J, Jones E, Kertes P, O’Donnell D, Sylviris S, Tonkin A, Fabini R, Kearney L, Lim R, Molan M, Smith G, Wellman C, Eng J, Hameed I, Shaw M, Gerbo S. Long-Term Results of the RAPCO Trials. Circulation 2020, 142: 1330-1338. PMID: 33017209, DOI: 10.1161/circulationaha.119.045427.Peer-Reviewed Original ResearchConceptsRight internal thoracic arteryFree right internal thoracic arteryRadial arteryPatient survival estimatesSaphenous veinYears of ageInternal thoracic artery graftsSurvival estimatesFree RITA graftThoracic artery graftsCoprimary end pointsCoronary bypass surgeryInternal thoracic arteryLong-term mortalityLong-term patencyCoronary targetsRA armRITA graftArtery graftBypass surgeryGraft failureRA groupPrimary outcomeThoracic arterySV graftsImpact of Operator Characteristics on Outcomes in Transcatheter Aortic Valve Replacement
Rong LQ, Gaudino M, Tam D, Mao J, Zheng X, Hameed I, Khan F, Salemi A, Sedrakyan A, Neuburger PJ, Fremes S. Impact of Operator Characteristics on Outcomes in Transcatheter Aortic Valve Replacement. The Annals Of Thoracic Surgery 2020, 111: 853-860. PMID: 32795521, DOI: 10.1016/j.athoracsur.2020.06.018.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementTranscatheter aortic valve replacement (TAVR) proceduresAortic valve replacement proceduresAortic valve replacementAcute myocardial infarctionHealth Statewide PlanningValve replacement proceduresOperator characteristicsInhospital outcomesTAVR volumeInhospital mortalityValve replacementPrimary outcomeMyocardial infarctionSubgroup analysisStatewide PlanningProvider characteristicsCardiology practiceNew York State DepartmentInterventional cardiologyTAVROperator specialtyReplacement proceduresMedical school locationSignificant differencesAssociation of Radial Artery Graft vs Saphenous Vein Graft With Long-term Cardiovascular Outcomes Among Patients Undergoing Coronary Artery Bypass Grafting
Gaudino M, Benedetto U, Fremes S, Ballman K, Biondi-Zoccai G, Sedrakyan A, Nasso G, Raman J, Buxton B, Hayward PA, Moat N, Collins P, Webb C, Peric M, Petrovic I, Yoo KJ, Hameed I, Di Franco A, Moscarelli M, Speziale G, Puskas JD, Girardi LN, Hare DL, Taggart DP. Association of Radial Artery Graft vs Saphenous Vein Graft With Long-term Cardiovascular Outcomes Among Patients Undergoing Coronary Artery Bypass Grafting. JAMA 2020, 324: 179-187. PMID: 32662861, PMCID: PMC7361649, DOI: 10.1001/jama.2020.8228.Peer-Reviewed Original ResearchConceptsCoronary artery bypassSaphenous vein graftsComposite of deathRadial artery graftArtery bypassVein graftsRadial arteryMyocardial infarctionArtery graftCardiovascular outcomesClinical outcomesSaphenous veinLong-term cardiovascular outcomesPatient-level pooled analysisCoronary Artery Bypass GraftingArtery Bypass GraftingIndividual participant dataBypass GraftingAdult patientsComposite outcomeSecondary outcomesPrimary outcomeRandomized trialsPooled analysisObservational studyCharacteristics of Contemporary Randomized Clinical Trials and Their Association With the Trial Funding Source in Invasive Cardiovascular Interventions
Gaudino M, Hameed I, Rahouma M, Khan FM, Tam DY, Biondi-Zoccai G, Demetres M, Charlson ME, Ruel M, Crea F, Falk V, Girardi LN, Fremes S, Chikwe J. Characteristics of Contemporary Randomized Clinical Trials and Their Association With the Trial Funding Source in Invasive Cardiovascular Interventions. JAMA Internal Medicine 2020, 180: 993-1001. PMID: 32478821, PMCID: PMC7265124, DOI: 10.1001/jamainternmed.2020.1670.Peer-Reviewed Original ResearchConceptsPrimary end pointInvasive cardiovascular interventionsPrimary outcomeClinical trialsEnd pointCardiovascular interventionsSignificant differencesComposite primary end pointContemporary Randomized Clinical TrialsStructural interventional cardiologyTrial funding sourceCardiac surgical proceduresRandomized clinical trialsNumber of patientsCross-sectional studyExperimental interventionReporting of trialsTreatment effectsMedian sample sizeLarge treatment effectsContemporary RCTsGuideline recommendationsEvidence-based practiceTrial sponsorshipFavorable outcomeOpen Repair of Descending Thoracic and Thoracoabdominal Aortic Aneurysms: A Meta-Analysis
Khan FM, Naik A, Hameed I, Robinson NB, Spadaccio C, Rahouma M, Yongle R, Demetres M, Chen H, Chang M, Girardi LN, Gaudino M. Open Repair of Descending Thoracic and Thoracoabdominal Aortic Aneurysms: A Meta-Analysis. The Annals Of Thoracic Surgery 2020, 110: 1941-1949. PMID: 32504596, DOI: 10.1016/j.athoracsur.2020.04.069.Peer-Reviewed Original ResearchConceptsThoracoabdominal aortic aneurysmsCerebrospinal fluid drainsOpen repairOperative mortalitySpinal cord injuryAortic aneurysmLate mortalityRespiratory failureRenal failureCord injuryMyocardial infarctionGeneric inverse variance methodFluid drainsHigh operative mortalityLow operative mortalityInverse variance methodThoracic aortic aneurysmSystematic literature searchPostoperative strokeOperative deathsPerioperative complicationsPostoperative outcomesSecondary outcomesPrimary outcomePooled rateSpinal cord injury after open and endovascular repair of descending thoracic and thoracoabdominal aortic aneurysms: A meta-analysis
Gaudino M, Khan FM, Rahouma M, Naik A, Hameed I, Spadaccio C, Robinson NB, Ruan Y, Demetres M, Oakley CT, Gambardella I, Iannacone EM, Lau C, Girardi LN. Spinal cord injury after open and endovascular repair of descending thoracic and thoracoabdominal aortic aneurysms: A meta-analysis. Journal Of Thoracic And Cardiovascular Surgery 2020, 163: 552-564. PMID: 32561196, DOI: 10.1016/j.jtcvs.2020.04.126.Peer-Reviewed Original ResearchConceptsThoracoabdominal aortic aneurysmsPooled rateTAAA repairOperative mortalityEndovascular repairAneurysm repairAortic aneurysmSpinal cord injury ratesGeneric inverse variance methodCrawford extent ILong-term mortalityEndovascular aneurysm repairSpinal cord injuryInverse variance methodDrain-related complicationsSystematic literature searchPostoperative strokeLate mortalitySecondary outcomesOpen repairPrimary outcomeRelated complicationsThoracic aneurysmCord injuryInjury ratesComparison of the effects of hemodialysis and hemodiafiltration on left ventricular hypertrophy in end‐stage renal disease patients: A systematic review and meta‐analysis
Hameed I, Gaudino M, Naik A, Rahouma M, Robinson NB, Ruan Y, Demetres M, Bossola M. Comparison of the effects of hemodialysis and hemodiafiltration on left ventricular hypertrophy in end‐stage renal disease patients: A systematic review and meta‐analysis. Seminars In Dialysis 2020, 33: 120-126. PMID: 32159258, DOI: 10.1111/sdi.12864.Peer-Reviewed Original ResearchConceptsLeft ventricular mass indexEjection fractionMean differenceVentricular hypertrophySubgroup analysisConventional hemodialysisEnd-stage renal disease patientsLonger dialysis durationVentricular mass indexPooled mean differenceRenal disease patientsEffect of hemodialysisLeft ventricular hypertrophySystematic literature searchDialysis durationPrimary outcomeSecondary outcomesMass indexDisease patientsHemodialysisSystematic reviewHemodiafiltrationLowest mean differenceLiterature searchPatients
2019
Effect of atrial pacing on post-operative atrial fibrillation following coronary artery bypass grafting: Pairwise and network meta-analyses
Ruan Y, Robinson NB, Naik A, Silva M, Hameed I, Rahouma M, Oakley C, Di Franco A, Zamvar V, Girardi LN, Gaudino M. Effect of atrial pacing on post-operative atrial fibrillation following coronary artery bypass grafting: Pairwise and network meta-analyses. International Journal Of Cardiology 2019, 302: 103-107. PMID: 31837901, DOI: 10.1016/j.ijcard.2019.12.009.Peer-Reviewed Original ResearchConceptsPost-operative atrial fibrillationCoronary artery bypassBiA pacingAtrial pacingArtery bypassSecondary outcomesAtrial fibrillationIncidence of POAFGeneric inverse variance methodRight atrial pacingInverse variance methodLargest risk reductionSystematic literature searchPOAF incidenceOperative mortalityPostoperative bleedingPrimary outcomePacing modalitiesClinical trialsLower incidencePacingLiterature searchIncidenceFibrillationRisk reductionThree‐Dimensional Echocardiography for Transcatheter Aortic Valve Replacement Sizing: A Systematic Review and Meta‐Analysis
Rong LQ, Hameed I, Salemi A, Rahouma M, Khan FM, Wijeysundera HC, Angiolillo DJ, Shore‐Lesserson L, Biondi‐Zoccai G, Girardi LN, Fremes SE, Gaudino M. Three‐Dimensional Echocardiography for Transcatheter Aortic Valve Replacement Sizing: A Systematic Review and Meta‐Analysis. Journal Of The American Heart Association 2019, 8: e013463. PMID: 31549579, PMCID: PMC6806040, DOI: 10.1161/jaha.119.013463.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisEchocardiography, Three-DimensionalFemaleHeart Valve ProsthesisHumansMaleMultidetector Computed TomographyObserver VariationPredictive Value of TestsProsthesis DesignRadiographic Image Interpretation, Computer-AssistedReproducibility of ResultsSeverity of Illness IndexTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsTranscatheter aortic valve replacementParavalvular aortic regurgitationAortic regurgitationPrimary outcomeAnnular diameterAnnular perimeterTranscatheter aortic valve replacement sizingSystematic reviewSevere symptomatic aortic stenosisVentricular outflow tract areaBackground Transcatheter aortic valve replacementMean annular diameterOutflow tract areaPre-TAVR planningSymptomatic aortic stenosisAortic valve replacementStandard of careRandom-effects modelSystematic literature searchAnnular areaThree-dimensional echocardiographyContrast exposureRenal dysfunctionAortic stenosisSecondary outcomesCerebral protection strategies in aortic arch surgery: A network meta-analysis
Hameed I, Rahouma M, Khan FM, Wingo M, Demetres M, Tam DY, Lau C, Iannacone EM, Di Franco A, Palaniappan A, Anderson H, Fremes SE, Girardi LN, Gaudino M. Cerebral protection strategies in aortic arch surgery: A network meta-analysis. Journal Of Thoracic And Cardiovascular Surgery 2019, 159: 18-31. PMID: 30902473, DOI: 10.1016/j.jtcvs.2019.02.045.Peer-Reviewed Original ResearchDeep hypothermic circulatory arrestAntegrade cerebral perfusionRetrograde cerebral perfusionHypothermic circulatory arrestAortic arch surgeryCerebral perfusionCirculatory arrestArch surgeryPostoperative strokeSecondary outcomesPrimary outcomeBilateral antegrade cerebral perfusionGeneric inverse variance methodCerebral protection strategiesCirculatory arrest durationTransient neurologic deficitsOperative mortality rateBetter postoperative outcomesInverse variance methodSystematic literature searchCerebral protectionOperative mortalityRespiratory complicationsNeurologic deficitsPostoperative outcomes