Risk of Metachronous Colorectal Neoplasm after a Segmental Colectomy in Lynch Syndrome Patients According to Mismatch Repair Gene Status
Quezada-Diaz FF, Hameed I, von Mueffling A, Salo-Mullen EE, Catalano A, Smith JJ, Weiser MR, Garcia-Aguilar J, Stadler ZK, Guillem JG. Risk of Metachronous Colorectal Neoplasm after a Segmental Colectomy in Lynch Syndrome Patients According to Mismatch Repair Gene Status. Journal Of The American College Of Surgeons 2020, 230: 669-675. PMID: 32007537, PMCID: PMC7104918, DOI: 10.1016/j.jamcollsurg.2020.01.005.Peer-Reviewed Original ResearchConceptsLP/P variantsMetachronous colorectal cancerColorectal cancerTotal colectomySegmental resectionSegmental colectomyMMR genesLS patientsLynch syndromeMetachronous colorectal neoplasmsMismatch repair gene statusPrimary end pointRetrospective cohort studyMMR germline mutationsLynch syndrome patientsQuality of lifeMismatch repair genesCRC overallCRC ratesEarly colectomyIndex resectionMedian followMSH2 carriersCRC incidenceCohort study