2019
Disagreement Between Randomized and Observational Evidence on the Use of Bilateral Internal Thoracic Artery Grafting: A Meta‐Analytic Approach
Gaudino M, Rahouma M, Hameed I, Khan FM, Taggart DP, Flather M, Biondi‐Zoccai G, Fremes SE. Disagreement Between Randomized and Observational Evidence on the Use of Bilateral Internal Thoracic Artery Grafting: A Meta‐Analytic Approach. Journal Of The American Heart Association 2019, 8: e014638. PMID: 31752642, PMCID: PMC6912987, DOI: 10.1161/jaha.119.014638.Peer-Reviewed Original ResearchConceptsInternal thoracic arteryObservational studyThoracic arterySurvival dataBilateral Internal Thoracic Artery GraftingBilateral internal thoracic artery groupBilateral internal thoracic arteryCox regression hazardPropensity-matched studyLong-term outcomesMost observational studiesArtery GraftingArtery groupImproved survivalControl armImproved outcomesControl groupSurvival curvesArteryBeneficial effectsMeta-analytic approachSurvivalPatientsExperimental groupOutcomes
2018
Galectin‐3 exacerbates ox‐LDL‐mediated endothelial injury by inducing inflammation via integrin β1‐RhoA‐JNK signaling activation
Chen X, Lin J, Hu T, Ren Z, Li L, Hameed I, Zhang X, Men C, Guo Y, Xu D, Zhan Y. Galectin‐3 exacerbates ox‐LDL‐mediated endothelial injury by inducing inflammation via integrin β1‐RhoA‐JNK signaling activation. Journal Of Cellular Physiology 2018, 234: 10990-11000. PMID: 30536538, PMCID: PMC6590151, DOI: 10.1002/jcp.27910.Peer-Reviewed Original ResearchMeSH KeywordsAtherosclerosisCell Adhesion MoleculesCell SurvivalEndothelium, VascularFas ReceptorGalectin 3Gene Expression RegulationHuman Umbilical Vein Endothelial CellsHumansInflammationIntegrin beta1JNK Mitogen-Activated Protein KinasesLipoproteins, LDLMAP Kinase Signaling SystemRhoA GTP-Binding ProteinConceptsHuman umbilical vascular endothelial cellsEndothelial injuryGal-3P-JNKInflammatory factorsGTP-RhoAGalectin-3Plasma galectin-3Systemic inflammatory disorderEndothelial cell injuryPathogenesis of atherosclerosisLow-density lipoproteinNF-κB activationVascular endothelial cellsEndothelial dysfunctionP-IKKβAS patientsInflammatory disordersP-p65P-IKKαCardiovascular diseaseOx-LDLCell injuryCCK8 assayControl group