Featured Publications
How Far Is Too Far? Cost-Effectiveness Analysis of Regionalized Rectal Cancer Surgery
Leeds I, Xu Z, Loria A, Pantel H, Mongiu A, Longo W, Reddy V. How Far Is Too Far? Cost-Effectiveness Analysis of Regionalized Rectal Cancer Surgery. Diseases Of The Colon & Rectum 2022, 66: 467-476. PMID: 36538713, DOI: 10.1097/dcr.0000000000002636.Peer-Reviewed Original ResearchConceptsMultivariable probabilistic sensitivity analysesCost-effectiveness standardsIncremental cost-effectiveness ratioProbabilistic sensitivity analysesCost-effectiveness analysisCost-effectiveness ratioTotal societal costsSensitivity analysisDecision analysis modelEl análisisSocietal perspectiveIncremental costPacientes con cáncerSocietal costsLos costosLargo plazoPolicy levelDecision analysisTotal costCostCost-Effectiveness of Aspirin for Extended Venous Thromboembolism Prophylaxis After Major Surgery for Inflammatory Bowel Disease
Leeds IL, Sklow B, Gorgun E, Liska D, Lightner AL, Hull TL, Steele SR, Holubar SD. Cost-Effectiveness of Aspirin for Extended Venous Thromboembolism Prophylaxis After Major Surgery for Inflammatory Bowel Disease. Journal Of Gastrointestinal Surgery 2022, 26: 1275-1285. PMID: 35277799, DOI: 10.1007/s11605-022-05287-z.Peer-Reviewed Original ResearchConceptsInflammatory bowel disease surgeryLow-dose aspirinQuality-adjusted life yearsThromboembolism prophylaxisDisease surgeryUnfavorable incremental cost-effectiveness ratiosLife yearsExtended venous thromboembolism prophylaxisPost-discharge event ratePocket costsIncremental cost-effectiveness ratioVenous thromboembolism prophylaxisEfficacy of aspirinInflammatory bowel diseaseMedian hospital costsMonte Carlo probabilistic sensitivity analysisCost-effectiveness ratioProbabilistic sensitivity analysesDecision analysis modelEnoxaparin regimenThromboembolism ratesVenous thromboembolismBowel diseaseColorectal surgeryCase patientsOn All Accounts: Cost-Effectiveness Analysis of Limited Preoperative Optimization Efforts Before Colon Cancer Surgery
Leeds IL, Drabo EF, Lehmann LS, Safar B, Johnston FM. On All Accounts: Cost-Effectiveness Analysis of Limited Preoperative Optimization Efforts Before Colon Cancer Surgery. Diseases Of The Colon & Rectum 2021, 64: 744-753. PMID: 33955409, PMCID: PMC8835996, DOI: 10.1097/dcr.0000000000001926.Peer-Reviewed Original ResearchConceptsCost-effectiveness analysisProbabilistic sensitivity analysesNet monetary benefitIncremental cost-effectiveness ratioTotal costCost-effectiveness ratioMonetary benefitsSensitivity analysisBreakeven costDominant strategyEconomic costsDecision analysis methodologyCostHypothetical scenariosAlto riesgoEl análisisAnálisisEconómicoBenefitsAnalysis methodologyReducciónRescuing Failure to Rescue—Patient Safety Indicator 04 on the Brink of Obsolescence
Leeds IL, Kachalia A, Haut ER. Rescuing Failure to Rescue—Patient Safety Indicator 04 on the Brink of Obsolescence. JAMA Surgery 2021, 156: 115-116. PMID: 33026428, DOI: 10.1001/jamasurg.2020.2971.Peer-Reviewed Original Research
2024
Surgical Outcomes and Utilization of Laparoscopic Versus Robotic Techniques for Elective Colectomy in Asian American and Native Hawaiian-Pacific Islanders (AAPI) Diagnosed With Colon Cancer
Ahuja V, Murthy S, Leeds I, Paredes L, Su D, Tsutsumi A, Perkal M, King J. Surgical Outcomes and Utilization of Laparoscopic Versus Robotic Techniques for Elective Colectomy in Asian American and Native Hawaiian-Pacific Islanders (AAPI) Diagnosed With Colon Cancer. Journal Of Surgical Research 2024, 302: 40-46. PMID: 39083904, DOI: 10.1016/j.jss.2024.07.007.Peer-Reviewed Original ResearchLaparoscopic colectomyRobotic colectomyAAPI patientsColorectal cancerLength of stayClinical outcomesNative Hawaiian Pacific IslanderAmerican College of Surgeons National Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseOperative timeQuality Improvement Program databaseMultivariate logistic regression analysisMean operative timeColorectal cancer resectionOutcomes of LCMinimally invasive approachMultivariate logistic regressionStandard of careLogistic regression analysisElective RCElective LCAnastomotic leakElective colectomySurgical outcomesEAES/SAGES evidence-based recommendations and expert consensus on optimization of perioperative care in older adults
Keller D, Curtis N, Burt H, Ammirati C, Collings A, Polk H, Carrano F, Antoniou S, Hanna N, Piotet L, Hill S, Cuijpers A, Tejedor P, Milone M, Andriopoulou E, Kontovounisios C, Leeds I, Awad Z, Barber M, Al-Mansour M, Nassif G, West M, Pryor A, Carli F, Demartines N, Bouvy N, Passera R, Arezzo A, Francis N. EAES/SAGES evidence-based recommendations and expert consensus on optimization of perioperative care in older adults. Surgical Endoscopy 2024, 38: 4104-4126. PMID: 38942944, PMCID: PMC11289045, DOI: 10.1007/s00464-024-10977-7.Peer-Reviewed Original ResearchEvidence-based recommendationsMinimally invasive surgeryOlder adultsOlder adult patientsAbdominal surgeryColorectal surgeryPerioperative carePerioperative care of older adultsAdult patientsCare of older adultsCorrection of anemiaOptimization of perioperative careInfluence surgical outcomesCertainty of evidenceCessation of smokingEvidence synthesisExpert opinionEvidence gapsSurgical outcomesPoor outcomeFunctional capacityERAS programOlder patientsPrehabilitationMeta-analysesPersonalized risk assessment of new onset depression in long-term cancer survivors.
Taylor M, Westvold S, Long J, Hyslop T, Wang S, Cecchini M, Leapman M, Leeds I, Lustberg M, Spees L, Wheeler S, Gross C, Oeffinger K, Dinan M. Personalized risk assessment of new onset depression in long-term cancer survivors. Journal Of Clinical Oncology 2024, 42: e13798-e13798. DOI: 10.1200/jco.2024.42.16_suppl.e13798.Peer-Reviewed Original ResearchHistory of depressionIncidence of depressionCumulative incidence of depressionRisk of developing depressionLong-term survivorsPredictors of depressionCancer survivorsDisease specific factorsCumulative incidenceNon-HispanicHigher risk of developing depressionRectal cancerLong-term cancer survivorsBreast cancer survivorsCensus tract povertyColon cancerEpisodes of bipolar I disorderPrevalence of depressionMean survival time modelsDiagnosis of depressionReceipt of treatmentAssociated with prior historyHormone receptor statusPatients aged <Adjuvant endocrine therapy1224 PREOPERATIVE PSYCHOSOCIAL RISK BURDEN AMONG PATIENTS UNDEROING MAJOR THORACIC AND ABDOMINAL SURGERY
Park E, Schultz K, Pantel H, Mongiu A, Reddy V, Leeds I. 1224 PREOPERATIVE PSYCHOSOCIAL RISK BURDEN AMONG PATIENTS UNDEROING MAJOR THORACIC AND ABDOMINAL SURGERY. Gastroenterology 2024, 166: s-1850-s-1851. DOI: 10.1016/s0016-5085(24)04735-8.Peer-Reviewed Original ResearchPostoperative Outcomes Associated with the Timing of Surgery After SARS-CoV-2 Infection
Leeds I, Park L, Akgun K, Weintrob A, Justice A, King J. Postoperative Outcomes Associated with the Timing of Surgery After SARS-CoV-2 Infection. Annals Of Surgery 2024, 280: 241-247. PMID: 38323413, PMCID: PMC11236522, DOI: 10.1097/sla.0000000000006227.Peer-Reviewed Original ResearchIncreased 90-day mortalitySARS-CoV-2 infectionDays of infectionPostoperative outcomesSARS-CoV-2Increased post-operative mortalityPositive testRetrospective cohort of patientsUS Veterans Health Administration facilitiesVeterans Health Administration facilitiesPost-operative mortalityMultivariate modelTime of surgeryAdverse surgical outcomesCohort of patientsMultivariate logistic regression modelSurgical procedure groupsSARS-CoV-2 positive testDeferred surgeryPrimary endpointSurgery intervalSurgical outcomesSurgical cohortUninfected patientsASA 4
2023
The Predictors of Complete Pathologic Response in Rectal Cancer during the Total Neoadjuvant Therapy Era: A Systematic Review
Flom E, Schultz K, Pantel H, Leeds I. The Predictors of Complete Pathologic Response in Rectal Cancer during the Total Neoadjuvant Therapy Era: A Systematic Review. Cancers 2023, 15: 5853. PMID: 38136397, PMCID: PMC10742121, DOI: 10.3390/cancers15245853.Peer-Reviewed Original ResearchTotal neoadjuvant therapyPathologic complete responseClinical complete responseNeoadjuvant therapyComplete responseSystematic reviewRectal cancerTumor responseClinical stage 2Complete pathologic responseRetrospective cohort studyRandomized clinical trialsHeterogeneity of studiesLevel of evidenceElectronic databases EmbaseIdentification of predictorsCancer treatment paradigmLong-term trialsNeoadjuvant chemotherapyTherapy eraPatient demographicsPreoperative predictorsClinical factorsClinicopathologic factorsCohort studyMore problems, more money: Identifying and predicting high-cost rescue after colorectal surgery
Leeds I, Moore M, Schultz K, Canner J, Pantel H, Mongiu A, Reddy V, Schneider E. More problems, more money: Identifying and predicting high-cost rescue after colorectal surgery. Surgery Open Science 2023, 16: 148-154. PMID: 38026825, PMCID: PMC10656212, DOI: 10.1016/j.sopen.2023.10.007.Peer-Reviewed Original ResearchColorectal surgeryElective surgeryMedian total inpatient costsAdditional major proceduresElective colorectal surgeryPreoperative clinical predictorsCongestive heart failureGreater healthcare utilizationMultivariable Poisson regressionNational Inpatient SampleTotal inpatient costsElective colectomyCost-conscious careAdult patientsUneventful recoveryClinical predictorsHeart failureHealthcare utilizationInpatient costsSecondary proceduresInpatient SampleHealthcare costsMedian increaseSurgeryPatientsRacial disparities in complications following elective colon cancer resection: Impact of laparoscopic versus robotic approaches
Ahuja V, Paredes L, Leeds I, Perkal M, Tsutsumi A, Bhandarkar S, King J. Racial disparities in complications following elective colon cancer resection: Impact of laparoscopic versus robotic approaches. The American Journal Of Surgery 2023, 227: 85-89. PMID: 37806892, PMCID: PMC10842593, DOI: 10.1016/j.amjsurg.2023.09.038.Peer-Reviewed Original ResearchConceptsRC patientsLaparoscopic colectomyElective colon cancer resectionImpact of laparoscopicACS-NSQIP databaseColon cancer resectionMultivariable logistic regressionCancer resectionWhite patientsBlack patientsRobotic colectomyHigher complicationsOperative approachMinority patientsPatientsComplicationsColectomyLogistic regressionRobotic approachRacial disparitiesLaparoscopicCausal pathwaysLower ratesOutcomesMortalityCommentary: Machine learning in clinical decision-making
Filiberto A, Donoho D, Leeds I, Loftus T. Commentary: Machine learning in clinical decision-making. Frontiers In Digital Health 2023, 5: 1214111. PMID: 37588023, PMCID: PMC10426737, DOI: 10.3389/fdgth.2023.1214111.Peer-Reviewed Original ResearchRelative Burden of Cancer and Noncancer Mortality Among Long-Term Survivors of Breast, Prostate, and Colorectal Cancer in the US
Kc M, Fan J, Hyslop T, Hassan S, Cecchini M, Wang S, Silber A, Leapman M, Leeds I, Wheeler S, Spees L, Gross C, Lustberg M, Greenup R, Justice A, Oeffinger K, Dinan M. Relative Burden of Cancer and Noncancer Mortality Among Long-Term Survivors of Breast, Prostate, and Colorectal Cancer in the US. JAMA Network Open 2023, 6: e2323115. PMID: 37436746, PMCID: PMC10339147, DOI: 10.1001/jamanetworkopen.2023.23115.Peer-Reviewed Original ResearchConceptsLong-term survivorsCancer-specific mortalityColorectal cancerCancer cohortReceptor statusInitial diagnosisGleason scoreProstate cancerBreast cancerLong-term adult survivorsMedian cancer-specific survivalEnd Results cancer registryProstate-specific antigen levelRectal cancer cohortCancer-specific survivalStage III diseaseYear of diagnosisProgesterone receptor statusEstrogen receptor statusProportion of deathsSurvival time ratioEarly-stage cancerNononcologic outcomesIndex cancerLocalized diseaseClinical outcomes of elective robotic vs laparoscopic surgery for colon cancer utilizing a large national database
Ahuja V, Paredes L, Leeds I, Perkal M, King J. Clinical outcomes of elective robotic vs laparoscopic surgery for colon cancer utilizing a large national database. Surgical Endoscopy 2023, 37: 7199-7205. PMID: 37365394, DOI: 10.1007/s00464-023-10215-6.Peer-Reviewed Original ResearchConceptsAnastomotic leak rateBody mass indexLarge national databaseOverall complicationsAnastomotic leakOperative timeInvasive colectomyColon cancerElective colon cancer resectionHigher body mass indexNational databaseOperating roomPost-operative lengthColon cancer resectionLonger operative timeRange of surgeryNon-Hispanic whitesCancer resectionACS-NSQIPLaparoscopic colectomyClinical outcomesMass indexLaparoscopic counterpartLaparoscopic surgeryPatient outcomesPerioperative Immunosuppression in Inflammatory Bowel Disease
Leeds I, Lightner A, Kurowski J. Perioperative Immunosuppression in Inflammatory Bowel Disease. 2023, 613-617. DOI: 10.1007/978-3-031-14744-9_43.ChaptersInflammatory bowel diseaseBowel diseasePotential postoperative morbidityChronic steroid useEndoscopic remissionPostoperative morbidityPerioperative effectsPerioperative periodPharmacologic therapyPostoperative outcomesPerioperative immunosuppressionUlcerative colitisCrohn's diseaseImmunosuppressive agentsOpportunistic infectionsSteroid useImmunosuppressive effectsImmunosuppressive propertiesMonoclonal antibodiesDiseaseImmunosuppressionHigh rateRiskColitisCorticosteroidsSo You Want to be a Program Director? Career Paths of Colon and Rectal Surgery Residency Program Directors
Esposito A, Coppersmith N, Flom E, Chung M, Reddy V, Leeds I, Longo W, Pantel H, Yoo P, Mongiu A. So You Want to be a Program Director? Career Paths of Colon and Rectal Surgery Residency Program Directors. Journal Of Surgical Education 2023, 80: 588-596. PMID: 36658062, DOI: 10.1016/j.jsurg.2022.12.009.Peer-Reviewed Original ResearchTargeting Health-Related Social Risks in the Clinical Setting: New Policy Momentum and Practice Considerations.
Shultz B, Oladele C, Leeds I, Gluck A, Gross C. Targeting Health-Related Social Risks in the Clinical Setting: New Policy Momentum and Practice Considerations. The Journal Of Law, Medicine & Ethics 2023, 51: 777-785. PMID: 38477272, DOI: 10.1017/jme.2024.25.Peer-Reviewed Original ResearchConceptsSocial determinants of healthDeterminants of healthHealth care entitiesHealth inequalitiesSocial determinantsEmergency medicineHealth careCare entitiesAccrediting organizationsHealthClinical practiceField of oncologyClinical settingPolicy momentumSocial risksCareProvidersPracticeInterventionIllnessPractical considerationsAccreditationOncologyFederal governmentClinic
2022
Do Cultures From Percutaneously Drained Intra-abdominal Abscesses Change Treatment? A Retrospective Review
Esposito A, Zhang Y, Nagarkatti N, Laird W, Coppersmith N, Reddy V, Leeds I, Mongiu A, Longo W, Hao R, Pantel H. Do Cultures From Percutaneously Drained Intra-abdominal Abscesses Change Treatment? A Retrospective Review. Diseases Of The Colon & Rectum 2022, 66: 451-457. PMID: 36538708, DOI: 10.1097/dcr.0000000000002644.Peer-Reviewed Original ResearchConceptsIntra-abdominal abscessPercutaneous drainAntimicrobial therapyLos pacientesAbdominal abscessSingle university-affiliated institutionRetrospective medical record reviewEmpiric antibiotic regimensSolid organ transplantsMedical record reviewUniversity-affiliated institutionCulture dataAntibiotic coursesAbdominal infectionAntibiotic regimensActive smokersMedian ageActive chemotherapyRecord reviewEvidence-based practiceMedian lengthUtility of cultureFemale sexIntraoperative culturesInclusion criteriaShort- and Long-term Outcomes of Ileal Pouch Anal Anastomosis Construction in Obese Patients With Ulcerative Colitis
Leeds IL, Holubar SD, Hull TL, Lipman JM, Lightner AL, Sklow B, Steele SR. Short- and Long-term Outcomes of Ileal Pouch Anal Anastomosis Construction in Obese Patients With Ulcerative Colitis. Diseases Of The Colon & Rectum 2022, 65: e782-e789. PMID: 34958050, DOI: 10.1097/dcr.0000000000002169.Peer-Reviewed Original ResearchConceptsLong-term pouch failureObese patientsUlcerative colitisNonobese patientsPostoperative complicationsPouch failurePouch surgeryColitis ulcerosaASA class 3Intraoperative technical difficultiesOutcomes of obeseAssociation of obesityPouch failure rateWorse clinical outcomesQuaternary referral centerLong-term outcomesLength of stayIleoanal pouch surgeryQuality of lifePouch leakPouch survivalPreoperative steroidsASA 3Anastomotic leakCohort study